Interferon-regulated genetic programs and JAK/STAT pathway activate the intronic promoter of the short ACE2 isoform in renal proximal tubules.

ACE2 dACE2 interferon proximal tubule regulatory elements

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
19 Jan 2021
Historique:
pubmed: 28 1 2021
medline: 28 1 2021
entrez: 27 1 2021
Statut: epublish

Résumé

Recently, a short, interferon-inducible isoform of Angiotensin-Converting Enzyme 2 (ACE2), dACE2 was identified. ACE2 is a SARS-Cov-2 receptor and changes in its renal expression have been linked to several human nephropathies. These changes were never analyzed in context of

Identifiants

DOI: 10.1101/2021.01.15.426908 PMID: 33501441 PMC: PMC7836111
pubmed: 33501441
doi: 10.1101/2021.01.15.426908
pmc: PMC7836111
pii:
doi:

Types de publication

Preprint

Langues

eng

Déclaration de conflit d'intérêts

DISCLOSURES The authors declare no competing interests.

Auteurs

Jakub Jankowski (J)

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, U.S. National Institutes of Health, Bethesda, MD 20892, USA.
Department of Physiology and Pathophysiology, University of Veterinary Medicine, Veterinärplatz 1, 1210, Vienna, Austria.

Hye Kyung Lee (HK)

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, U.S. National Institutes of Health, Bethesda, MD 20892, USA.

Julia Wilflingseder (J)

Department of Physiology and Pathophysiology, University of Veterinary Medicine, Veterinärplatz 1, 1210, Vienna, Austria.

Lothar Hennighausen (L)

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, U.S. National Institutes of Health, Bethesda, MD 20892, USA.

Classifications MeSH