Rapid and Selective Biomarker Detection with Conductometric Sensors.
antibodies
biosensors
oxides
thin films
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
08
09
2020
revised:
18
11
2020
pubmed:
28
1
2021
medline:
10
7
2021
entrez:
27
1
2021
Statut:
ppublish
Résumé
The biomarker detection in human body fluids is crucial as biomarkers are important in diagnosing diseases. Conventional invasive techniques for biomarker detection are associated with infection, tissue damage, and discomfort. Non-invasive devices are an attractive alternative. Here, metal oxide (oxygen-deficient zinc oxide, ZnO) based conductometric sensors with two-terminal electrodes for rapid detection of biomarkers in real-time, are presented. This platform can be engineered for non-invasive, sensitive, and on-demand selective detection of biomarkers based on surface functionalization. The three novelties in this biosensing technique include an on-demand target selection device platform, short (<10 min) incubation times, and real-time monitoring of the biomarker of interest by electrical (resistance change) measurements. Cardiac inflammatory biomarkers interleukin 6 (IL-6) and C-reactive protein (CRP) are used as the model antigens. The devices can detect 100× lower concentration of IL-6 than healthy levels in human saliva and sweat and 1000× and ≈50× lower CRP concentrations than healthy levels in human saliva and sweat, respectively. The devices show high selectivity for IL-6 and CRP antigens when tested with a mixture of biomarkers. This sensor platform can be extended to selective measurements for viruses or DNA screening, which enables a new category of compact and rapid point-of-care medical devices.
Identifiants
pubmed: 33502115
doi: 10.1002/smll.202005582
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2005582Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
M. Bariya, H. Y. Y. Nyein, A. Javey, Nat. Electron. 2018, 1, 160.
J. Kim, A. S. Campbell, B. E.-.F. De Ávila, J. Wang, Nat. Biotechnol. 2019, 37, 389.
Y. Yang, W. Gao, Chem. Soc. Rev. 2019, 48, 1465.
S. Aydin, Peptides 2015, 72, 4.
P. J. Tighe, R. R. Ryder, I. Todd, L. C. Fairclough, Proteomics: Clin. Appl. 2015, 9, 406.
S. M. Borisov, O. S. Wolfbeis, Chem. Rev. 2008, 108, 423.
C. Chen, J. Wang, Analyst 2020, 145, 1605.
K. Länge, B. E. Rapp, M. Rapp, Anal. Bioanal. Chem. 2008, 391, 1509.
P. Skládal, Anal. Chem. 2016, 79, 127.
K. Ramanathan, B. Danielsson, Biosens. Bioelectron. 2001, 16, 417.
Y. Zhang, S. Tadigadapa, Biosens. Bioelectron. 2004, 19, 1733.
J.-M. Moon, N. Thapliyal, K. K. Hussain, R. N. Goyal, Y.-B. Shim, Biosens. Bioelectron. 2018, 102, 540.
E. Hamidi-Asl, I. Palchetti, E. Hasheminejad, M. Mascini, Talanta 2013, 115, 74.
E. O. Blair, D. K. Corrigan, Biosens. Bioelectron. 2019, 134, 57.
C. Chen, Q. Xie, D. Yang, H. Xiao, Y. Fu, Y. Tan, S. Yao, RSC Adv. 2013, 3, 4473.
A. Khanmohammadi, A. Aghaie, E. Vahedi, A. Qazvini, M. Ghanei, A. Afkhami, A. Hajian, H. Bagheri, Talanta 2020, 206, 120251.
B. Rezaei, M. Ghani, A. M. Shoushtari, M. Rabiee, Biosens. Bioelectron. 2016, 78, 513.
A. Sinha, X. Lu, L. Wu, D. Tan, Y. Li, J. Chen, R. Jain, TrAC,Trends Anal. Chem. 2018, 98, 174.
C. N. Kotanen, F. G. Moussy, S. Carrara, A. Guiseppi-Elie, Biosens. Bioelectron. 2012, 35, 14.
J. Ding, W. Qin, Trends Anal. Chem. 2020, 124, 115803.
N. Jaffrezic-Renault, S. Dzyadevych, Sensors 2008, 8, 2569.
Y. Xu, X. Xie, Y. Duan, L. Wang, Z. Cheng, J. Cheng, Biosens. Bioelectron. 2016, 77, 824.
T.-T. Tran, A. Mulchandani, TrAC, Trends Anal. Chem. 2016, 79, 222.
M. J. Limo, A. Sola-Rabada, E. Boix, V. Thota, Z. C. Westcott, V. Puddu, C. C. Perry, Chem. Rev. 2018, 118, 11118.
Md. M. Rahman, A. J. S. Ahammad, J.-H. Jin, S. J. Ahn, J.-J. Lee, Sensors 2010, 10, 4855.
P. Zhu, Z. Weng, X. Li, X. Liu, S. Wu, K. W. K. Yeung, X. Wang, Z. Cui, X. Yang, P. K. Chu, Adv. Mater. Interfaces 2016, 3, 1500494.
N. P. Shetti, S. D. Bukkitgar, K. R. Reddy, C. V. Reddy, T. M. Aminabhavi, Biosens. Bioelectron. 2019, 141, 111417.
M. L. M. Napi, S. M. Sultan, R. Ismail, K. W. How, M. K. Ahmad, Materials 2019, 12, 2985.
Z. H. Ibupoto, N. Jamal, K. Khun, M. Willander, Sens. Actuators, B 2012, 166-167, 809.
Y. Zhao, W. Li, L. Pan, D. Zhai, Y Wang, L. Li, W. Cheng, W. Yin, X. Wang, J.-B. Xu, Y Shi, Sci. Rep. 2016, 6, 32327.
L. Cao, J. Kiely, M. Piano, R. Luxton, Sci. Rep. 2018, 8, 1.
A. Qureshi, Y. Gurbuz, J. H. Niazi, Sens. Actuators, B 2012, 171-172, 62.
J. Hartman, W. H. Frishman, Cardiol. Rev. 2014, 22, 147.
S. Krishnamoorthy, A. A. Iliadis, T. Bei, G. P. Chrousos, Biosens. Bioelectron. 2008, 24, 313.
S. Krishnamoorthy, T. Bei, E. Zoumakis, G. P. Chrousos, A. A. Iliadis, Biosens. Bioelectron. 2006, 22, 707.
H.-L. Guo, Q. Zhu, X.-L. Wu, Y.-F. Jiang, X. Xie, A.-W. Xu, Nanoscale 2015, 7, 7216.
P. Gutruf, S. Walia, S. Sriram, M. Bhaskaran, Adv. Electron. Mater. 2015, 1, 1500264.
Z. Geng, X. Kong, W. Chen, H. Su, Y. Liu, F. Cai, G. Wang, J. Zeng, Angew. Chem., Int. Ed. 2018, 57, 6054.
D. Chen, L. Lv, L. Peng, J. Peng, Y. Cao, X. Wang, X. Wang, Q. Wu, J. Tu, Ceram. Int. 2019, 45, 18044.
M. Jacobs, S. Muthukumar, A. Panneer Selvam, J. Engel Craven, S. Prasad, Biosens. Bioelectron. 2014, 55, 7.
P. Gutruf, E. Zeller, S. Walia, H. Nili, S. Sriram, M. Bhaskaran, Small 2015, 11, 4532.
J. Wang, Z. Wang, B. Huang, Y. Ma, Y. Liu, X. Qin, X. Zhang, Y. Dai, ACS Appl. Mater. Interfaces 2012, 4, 4024.
M. Chen, X. Wang, Y. H. Yu, Z. L. Pei, X. D. Bai, C. Sun, R. F. Huang, L. S. Wen, Appl. Surf. Sci. 2000, 158, 134.
S.-S. Li, Y.-K. Su, RSC Adv. 2019, 9, 2941.
W. Water, S.-Y. Chu, Mater. Lett. 2002, 55, 67.
C. D. Corso, A. Dickherber, W. D. Hunt, Biosens. Bioelectron. 2008, 24, 805.
V. Purcar, R. Şomoghi, S. Niţu, C.-A. Nicolae, E. Alexandrescu, I. Gîfu, A. Gabor, H. Stroescu, R. Ianchiş, S. Căprărescu, L. Cinteză, Nanomaterials 2017, 7, 439.
T. Oh, C. K. Choi, J. Korean Phy. Soc. 2010, 56, 1150.
R. D. Munje, S. Muthukumar, B. Jagannath, S. Prasad, Sci. Rep. 2017, 7, 1950.
P. O. Andersson, P. Viberg, P. Forsberg, F. Nikolajeff, L. Österlund, M. Karlsson, Anal. Bioanal. Chem. 2016, 408, 3675.
A. Marques-Deak, G. Cizza, F. Eskandari, S. Torvik, I. C. Christie, E. M. Sternberg, T. M. Phillips, J. Immunol. Methods 2006, 315, 99.
H. Batool, A. Nadeem, M. Kashif, F. Shahzad, R. Tahir, N. Afzal, BioMed Res. Int. 2018, 2018, 8531961.
V. Machado, M. F. Mesquita, M. A. Bernardo, E. Casal, L. Proença, J. J. Mendes, Peer J. 2018, 6, e4710.
B. Jagannath, K.-C. Lin, M. Pali, D. Sankhala, S. Muthukumar, S. Prasad, Inflammatory Bowel Dis. 2020, 26, 1533.
C. Punyadeera, G. Dimeski, K. Kostner, P. Beyerlein, J. Cooper-White, J. Immunol. Methods 2011, 373, 19.
L. S. S. Kumar, X. Wang, J. Hagen, R. Naik, I. Papautsky, J. Heikenfeld, Anal. Methods 2016, 8, 3440.
E. B. Aydın, Talanta 2020, 215, 120909.
T. Yang, S. Wang, H. Jin, W. Bao, S. Huang, J. Wang, Sens. Actuators, B 2013, 178, 310.
F. Ding, Int. J. Electrochem. Sci. 2017, 12, 11646.
Y. Lou, T. He, F. Jiang, J.-J. Shi, J.-J. Zhu, Talanta 2014, 122, 135.
J. Zhang, W. Zhang, J. Guo, J. Wang, Y. Zhang, Anal. Biochem. 2017, 539, 1.
I. Letchumanan, M. K. Md Arshad, S. R. Balakrishnan, S. C. B. Gopinath, Biosens. Bioelectron. 2019, 130, 40.
Z. Wang, P. Dong, Z. Sun, C. Sun, H. Bu, J. Han, S. Chen, G. Xie, J. Mater. Chem, B 2018, 6, 2426.
G. Mumcu, H. Cimilli, U. Karacayli, N. Inanc, F. Ture-Ozdemir, E. Eksioglu-Demiralp, T. Ergun, H. Direskeneli, Arch. Oral Biol. 2012, 57, 642.
A. Joharimoghadam, M. Tajdini, A. Bozorgi, Kardiol. Pol. 2017, 75, 71.
V. Mishra, R. Patil, V. Khanna, A. Tripathi, V. Singh, S. Pandey, A. Chaurasia, J. Clin. Diag. Res. 2018, 12, 44.
M. Liu, J. Chen, D. Huang, J. Ke, W. Wu, Heart Asia 2014, 6, 130.
M. L. Salter, B. Lau, S. H. Mehta, V. F. Go, S. Leng, G. D. Kirk, J. Acquired Immune Defic. Syndr. 2013, 64, 488.