Alive and at home: Five-year outcomes in older adults following emergency general surgery.


Journal

The journal of trauma and acute care surgery
ISSN: 2163-0763
Titre abrégé: J Trauma Acute Care Surg
Pays: United States
ID NLM: 101570622

Informations de publication

Date de publication:
01 02 2021
Historique:
entrez: 27 1 2021
pubmed: 28 1 2021
medline: 16 4 2021
Statut: ppublish

Résumé

While the short-term risks of emergency general surgery (EGS) admission among older adults have been studied, little is known about long-term functional outcomes in this population. Our objective was to evaluate the relationship between EGS admission and the probability of an older adult being alive and residing in their own home 5 years later. We also examined the extent to which specific EGS diagnoses, need for surgery, and frailty modified this relationship. We performed a population-based, retrospective cohort study of community-dwelling older adults (age, ≥65 years) admitted to hospital for one of eight EGS diagnoses (appendicitis, cholecystitis, diverticulitis, strangulated hernia, bowel obstruction, peptic ulcer disease, intestinal ischemia, or perforated viscus) between 2006 and 2018 in Ontario, Canada. Cases were matched to controls from the general population. Time spent alive and at home (measured as time to nursing home admission or death) was compared between cases and controls using Kaplan-Meier analysis and Cox models. A total of 90,245 older adults admitted with an EGS diagnosis were matched with controls. In the 5 years following an EGS admission, cases experienced significantly fewer months alive and at home compared with controls (mean time, 43 vs. 50 months; p < 0.001). Except for patients operated on for appendicitis and cholecystitis, all remaining patient subgroups experienced reduced time alive and at home compared with controls (p < 0.001). Cases remained at elevated risk of nursing home admission or death compared with controls for the entirety of the 5-year follow-up (hazard ratio, 1.17-5.11). Older adults who required hospitalization for an EGS diagnosis were at higher risk for death or admission to a nursing home for at least 5 years following admission compared with controls. However, most patients (57%) remained alive and living in their own home at the end of this 5-year period. Epidemiological, level III.

Sections du résumé

BACKGROUND
While the short-term risks of emergency general surgery (EGS) admission among older adults have been studied, little is known about long-term functional outcomes in this population. Our objective was to evaluate the relationship between EGS admission and the probability of an older adult being alive and residing in their own home 5 years later. We also examined the extent to which specific EGS diagnoses, need for surgery, and frailty modified this relationship.
METHODS
We performed a population-based, retrospective cohort study of community-dwelling older adults (age, ≥65 years) admitted to hospital for one of eight EGS diagnoses (appendicitis, cholecystitis, diverticulitis, strangulated hernia, bowel obstruction, peptic ulcer disease, intestinal ischemia, or perforated viscus) between 2006 and 2018 in Ontario, Canada. Cases were matched to controls from the general population. Time spent alive and at home (measured as time to nursing home admission or death) was compared between cases and controls using Kaplan-Meier analysis and Cox models.
RESULTS
A total of 90,245 older adults admitted with an EGS diagnosis were matched with controls. In the 5 years following an EGS admission, cases experienced significantly fewer months alive and at home compared with controls (mean time, 43 vs. 50 months; p < 0.001). Except for patients operated on for appendicitis and cholecystitis, all remaining patient subgroups experienced reduced time alive and at home compared with controls (p < 0.001). Cases remained at elevated risk of nursing home admission or death compared with controls for the entirety of the 5-year follow-up (hazard ratio, 1.17-5.11).
CONCLUSION
Older adults who required hospitalization for an EGS diagnosis were at higher risk for death or admission to a nursing home for at least 5 years following admission compared with controls. However, most patients (57%) remained alive and living in their own home at the end of this 5-year period.
LEVEL OF EVIDENCE
Epidemiological, level III.

Identifiants

pubmed: 33502146
doi: 10.1097/TA.0000000000003018
pii: 01586154-202102000-00011
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

287-295

Informations de copyright

Copyright © 2020 American Association for the Surgery of Trauma.

Références

Peden CJ. Emergency surgery in the elderly patient: a quality improvement approach. Anaesthesia . 2011;66(6):440–445.
Coccolini F, Kluger Y, Ansaloni L, et al. WSES worldwide emergency general surgery formation and evaluation project. World J Emerg Surg . 2018;13(1):13.
Lyu HG, Najjar P, Havens JM. Past, present, and future of emergency general surgery in the USA. Acute Med Surg . 2018;5(2):119–122.
Becher RD, Davis KA, Rotondo MF, Coimbra R. Ongoing evolution of emergency general surgery as a surgical subspecialty. J Am Coll Surg . 2018;226(2):194–200.
Gale SC, Shafi S, Dombrovskiy VY, Arumugam D, Crystal JS. The public health burden of emergency general surgery in the United States: a 10-year analysis of the Nationwide Inpatient Sample—2001 to 2010. J Trauma Acute Care Surg . 2014;77(2):202–208.
Bruns BR, Tesoriero R, Narayan M, Klyushnenkova EN, Chen H, Scalea TM, Diaz JJ. Emergency general surgery: defining burden of disease in the state of Maryland. Am Surg . 2015;81(8):829–834.
Ramsay G, Wohlgemut JM, Jansen JO. Emergency general surgery in the United Kingdom: a lot of general, not many emergencies, and not much surgery. J Trauma Acute Care Surg . 2018;85(3):500–506.
Symons NR, Moorthy K, Almoudaris AM, Bottle A, Aylin P, Vincent CA, Faiz OD. Mortality in high-risk emergency general surgical admissions. Br J Surg . 2013;100(10):1318–1325.
Ogola GO, Gale SC, Haider A, Shafi S. The financial burden of emergency general surgery: national estimates 2010 to 2060. J Trauma Acute Care Surg . 2015;79(3):444–448.
Arenal JJ, Bengoechea-Beeby M. Mortality associated with emergency abdominal surgery in the elderly. Can J Surg . 2003;46(2):111–116.
Lawrence VA, Hazuda HP, Cornell JE, Pederson T, Bradshaw PT, Mulrow CD, Page CP. Functional independence after major abdominal surgery in the elderly. J Am Coll Surg . 2004;199(5):762–772.
Louis DJ, Hsu A, Brand MI, Saclarides TJ. Morbidity and mortality in octogenarians and older undergoing major intestinal surgery. Dis Colon Rectum . 2009;52(1):59–63.
Ingraham AM, Cohen ME, Raval MV, Ko CY, Nathens AB. Variation in quality of care after emergency general surgery procedures in the elderly. J Am Coll Surg . 2011;212(6):1039–1048.
Fukuda N, Wada J, Niki M, Sugiyama Y, Mushiake H. Factors predicting mortality in emergency abdominal surgery in the elderly. World J Emerg Surg . 2012;7(1):12.
Davis PJ, Bailey JG, Molinari M, Hayden J, Johnson PM. The impact of nonelective abdominal surgery on the residential status of older adult patients. Ann Surg . 2016;263(2):274–279.
McLean RC, McCallum IJ, Dixon S, O’Loughlin P. A 15-year retrospective analysis of the epidemiology and outcomes for elderly emergency general surgical admissions in the North East of England: a case for multidisciplinary geriatric input. Int J Surg . 2016;28:13–21.
Edwards AE, Seymour DG, Mccarthy JM, Crumplin MK. A 5-year survival study of general surgical patients aged 65 years and over. Anaesthesia . 1996;51(1):3–10.
Fried TR, Bradley EH, Towle VR, Allore H. Understanding the treatment preferences of seriously ill patients. N Engl J Med . 2002;346(14):1061–1066.
Fried TR, Tinetti M, Agostini J, Iannone L, Towle V. Health outcome prioritization to elicit preferences of older persons with multiple health conditions. Patient Educ Couns . 2011;83(2):278–282.
Becher RD, Murphy TE, Gahbauer EA, Leo-Summers L, Stabenau HF, Gill TM. Factors associated with functional recovery among older survivors of major surgery. Ann Surg . 2020;272(1):92–98.
Robinson TN. Function: an essential postoperative outcome for older adults. Ann Surg . 2018;268:918–919.
Bayer A-H, Harper L. Fixing to Stay: A National Survey on Housing and Home Modification Issues. Washington DC: AARP; 2000. Available at: https://www.worldcat.org/title/fixing-to-stay-a-national-survey-of-housing-and-home-modification-issues/oclc/320858075?referer=di&ht=edition . Accessed February 22, 2020.
Wolff JL, Kasper JD, Shore AD. Long-term care preferences among older adults: a moving target? J Aging Soc Policy . 2008;20(2):182–200.
Groff AC, Colla CH, Lee TH. Days spent at home — a patient-centered goal and outcome. N Engl J Med . 2016;375(17):1610–1612.
Xian Y, O’Brien EC, Fonarow GC, et al. Patient-centered research into outcomes stroke patients prefer and effectiveness research: implementing the patient-driven research paradigm to aid decision making in stroke care. Am Heart J . 2015;170(1):36–45.
Yu AYX, Rogers E, Wang M, Sajobi TT, Coutts SB, Menon BK, Hill MD, Smith EE. Population-based study of home-time by stroke type and correlation with modified Rankin score. Neurology . 2017;89(19):1970–1976.
Greene SJ, O’Brien EC, Mentz RJ, et al. Home-time after discharge among patients hospitalized with heart failure. J Am Coll Cardiol . 2018;71(23):2643–2652.
Gill TM, Gahbauer EA, Leo-Summers L, Murphy TE, Han L. Days spent at home in the last six months of life among community-living older persons. Am J Med . 2019;132(2):234–239.
Berian JR, Rosenthal RA, Baker TL, et al. Hospital standards to promote optimal surgical care of the older adult: a report from the Coalition for Quality in Geriatric Surgery. Ann Surg . 2018;267(2):280–290.
Working with ICES Data. ICES. Available at: https://www.ices.on.ca/Data-and-Privacy/ICES-data/Working-with-ICES-Data . Accessed November 24, 2019.
NACRS Emergency Department Visits and Length of Stay, 2016–2017. Available at: https://www.cihi.ca/en/nacrs-emergency-department-visits-and-length-of-stay-2016-2017 . Accessed July 30, 2019.
du Plessis V, Beshiri R, Bollman RD, Clemenson H. Definitions of rural. In: Rural and Small Town Canada Analysis Bulletin . 3rd ed. Vol 3. Ottawa, Canada: Statistics Canada; 2011.
The Johns Hopkins Adjusted Clinical Groups Technical Reference Guide, Version 10.0 . Baltimore, MD: Johns Hopkins University; 2011.
Sternberg SA, Bentur N, Abrams C, Spalter T, Karpati T, Lemberger J, Heymann AD. Identifying frail older people using predictive modeling. Am J Manag Care . 2012;18(10):e392–e397.
Bronskill S, Camacho X, Gruneir A, Ho MM. Health System Use by Frail Ontario Seniors: An In-Depth Examination of Four Vulnerable Cohorts . Toronto, Canada: Institute for Clinical Evaluative Sciences; 2011. Available at: https://www.ices.on.ca/Publications/Atlases-and-Reports/2011/Health-System-Use . Accessed August 20, 2018.
Bronskill SE, Stevenson JE, Hirdes JP, Henry DA. Aging in Ontario: Using Population-Based Data in the Evaluation of Trends in Health System Use. Healthcare Quarterly. Available at: http://www.longwoods.com/content/22377 . Published April 26, 2011. Accessed August 2, 2018.
McIsaac DI, Bryson GL, van Walraven C. Association of frailty and 1-year postoperative mortality following major elective noncardiac surgery: a population-based cohort study. JAMA Surg . 2016;151(6):538–545.
Neuman HB, Weiss JM, Leverson G, O’Connor ES, Greenblatt DY, LoConte NK, Greenberg CC, Smith MA. Predictors of short-term postoperative survival after elective colectomy in colon cancer patients ≥ 80 years of age. Ann Surg Oncol . 2013;20(5):1427–1435.
Matheson F; Ontario Agency for Health Protection and Promotion (Public Health Ontario). 2011 Ontario Marginalization Index: User Guide . Toronto, Canada: St. Michael’s Hospital; 2017:20.
Kagedan DJ, Abraham L, Goyert N, Li Q, Paszat LF, Kiss A, Earle CC, Mittmann N, Coburn NG. Beyond the dollar: influence of sociodemographic marginalization on surgical resection, adjuvant therapy, and survival in patients with pancreatic cancer. Cancer . 2016;122(20):3175–3182.
Mason SA, Nathens AB, Byrne JP, Diong C, Fowler RA, Karanicolas PJ, Moineddin R, Jeschke MG. Increased rate of long-term mortality among burn survivors: a population-based matched cohort study. Ann Surg . 2018;269(6):1192–1199.
Moin JS, Moineddin R, Upshur REG. Measuring the association between marginalization and multimorbidity in Ontario, Canada: a cross-sectional study. J Comorb . 2018;8(1):2235042X1881493.
Austin PC. Using the standardized difference to compare the prevalence of a binary variable between two groups in observational research. Commun Stat - Simul Comput . 2009;38(6):1228–1234.
Royston P, Parmar MK. Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome. BMC Med Res Methodol . 2013;13:152.
Kim DH, Uno H, Wei L-J. Restricted mean survival time as a measure to interpret clinical trial results. JAMA Cardiol . 2017;2(11):1179–1180.
Coylewright M, Palmer R, O’Neill ES, Robb JF, Fried TR. Patient-defined goals for the treatment of severe aortic stenosis: a qualitative analysis. Health Expect . 2016;19(5):1036–1043.
Akinbami F, Askari R, Steinberg J, Panizales M, Rogers SO Jr. Factors affecting morbidity in emergency general surgery. Am J Surg . 2011;201(4):456–462.
Kongwibulwut M, Chiang K, Lee JM, et al. Life after 90: predictors of mortality and performance of the ACS-NSQIP risk calculator in 4,724 nonagenarian patients undergoing emergency general surgery. J Trauma Acute Care Surg . 2019;86(5):853–857.
Feeney T, Castillo-Angeles M, Scott JW, Nitzschke SL, Salim A, Haider AH, Havens JM. The independent effect of emergency general surgery on outcomes varies depending on case type: a NSQIP outcomes study. Am J Surg . 2018;216(5):856–862.
Gazala S, Tul Y, Wagg A, Widder SL, Khadaroo RG. Quality of life and long-term outcomes of octo- and nonagenarians following acute care surgery: a cross sectional study. World J Emerg Surg . 2013;8:23.
Lee KC, Streid J, Sturgeon D, Lipsitz S, Weissman JS, Rosenthal RA, Kim DH, Mitchell SL, Cooper Z. The impact of frailty on long-term patient-oriented outcomes after emergency general surgery: a retrospective cohort study. J Am Geriatr Soc . 2020;68(5):1037–1043.
Stabenau HF, Becher RD, Gahbauer EA, Leo-Summers L, Allore HG, Gill TM. Functional trajectories before and after major surgery in older adults. Ann Surg . 2018;268:911–917.
Makary MA, Segev DL, Pronovost PJ, et al. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg . 2010;210(6):901–908.
Lin H-S, Watts JN, Peel NM, Hubbard RE. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr . 2016;16(1):157.

Auteurs

Matthew P Guttman (MP)

From the Institute of Health Policy, Management, and Evaluation (M.P.G., B.W.T., A.B.N., S.E.B., B.H.), Department of Surgery (M.P.G., A.B.N., B.H.), and Interdepartmental Division of Critical Care Medicine, Department of Medicine (B.W.T., B.H.), University of Toronto; Evaluative Clinical Sciences, Sunnybrook Research Institute (A.B.N., S.E.B., B.H.), Toronto, Ontario, Canada; American College of Surgeons, Trauma Quality Improvement Program (A.B.N.), Chicago, Illinois; and ICES Central, ICES (R.S., S.E.B., A.H.), Toronto, Ontario, Canada.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH