Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles.

Humans Jurkat Cells Magnetic Iron Oxide Nanoparticles / chemistry Receptors, CXCR4 / antagonists & inhibitors Signal Transduction / drug effects Silicon Dioxide / chemistry

Journal

Dalton transactions (Cambridge, England : 2003)
ISSN: 1477-9234
Titre abrégé: Dalton Trans
Pays: England
ID NLM: 101176026

Informations de publication

Date de publication:
09 Feb 2021
Historique:
pubmed: 28 1 2021
medline: 5 10 2021
entrez: 27 1 2021
Statut: ppublish

Résumé

The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells.

Identifiants

DOI: 10.1039/d0dt02626c PMID: 33502425
pubmed: 33502425
doi: 10.1039/d0dt02626c
doi:

Substances chimiques

Receptors, CXCR4 0
Silicon Dioxide 7631-86-9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1599-1603

Auteurs

Neazar E Baghdadi (NE)

Centre of Nanotechnology, King Abdul-Aziz University, Jeddah, Saudi Arabia and Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. s.j.archibald@hull.ac.uk.
ORCID: 0000-0003-4835-1929

Benjamin P Burke (BP)

Department of Biomedical Sciences and PET Research Centre, University of Hull Cottingham Road, Hull, HU6 7RX, UK.

Tahani Alresheedi (T)

Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. s.j.archibald@hull.ac.uk and Department of Biomedical Sciences and PET Research Centre, University of Hull Cottingham Road, Hull, HU6 7RX, UK and Department of Chemistry, College of Science and Art, Qassim University, Qassim, Saudi Arabia.

Shubhanchi Nigam (S)

Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. s.j.archibald@hull.ac.uk and Department of Biomedical Sciences and PET Research Centre, University of Hull Cottingham Road, Hull, HU6 7RX, UK.

Abdu Saeed (A)

Department of Physics, Faculty of Science, King Abdul-Aziz University, Jeddah 21589, Saudi Arabia.
ORCID: 0000-0002-8506-7188

Farooq Almutairi (F)

Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. s.j.archibald@hull.ac.uk and College of Applied Medical Sciences, University of Hafar Al-Batin, Hafar Al-Batin, Saudi Arabia.

Juozas Domarkas (J)

Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. s.j.archibald@hull.ac.uk and Department of Biomedical Sciences and PET Research Centre, University of Hull Cottingham Road, Hull, HU6 7RX, UK.

Abid Khan (A)

Department of Biomedical Sciences and PET Research Centre, University of Hull Cottingham Road, Hull, HU6 7RX, UK and Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Stephen J Archibald (SJ)

Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. s.j.archibald@hull.ac.uk and Department of Biomedical Sciences and PET Research Centre, University of Hull Cottingham Road, Hull, HU6 7RX, UK.
ORCID: 0000-0001-7581-8817

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multivalency in CXCR4 chemokine receptor...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Cellules Jurkat › Multivalency in CXCR4 chemokine receptor...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticules métalliques › Nanoparticules magnétiques d'oxyde de fer › Multivalency in CXCR4 chemokine receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteurs CXCR4 › Multivalency in CXCR4 chemokine receptor...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Multivalency in CXCR4 chemokine receptor...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du silicium › Silice › Multivalency in CXCR4 chemokine receptor...