Bufadienolides and ecdysteroids from the whole plants of Helleborus niger and their cytotoxicity.
A549 cells
Apoptosis
Bufadienolides
Cytotoxicity
Ecdysteroids
HL-60 cells
Helleborus niger
Ranunculaceae
SBC-3 cells
Journal
Journal of natural medicines
ISSN: 1861-0293
Titre abrégé: J Nat Med
Pays: Japan
ID NLM: 101518405
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
10
10
2020
accepted:
05
01
2021
pubmed:
28
1
2021
medline:
26
3
2021
entrez:
27
1
2021
Statut:
ppublish
Résumé
A new bufadienolide (1), two new bufadienolide glycosides (2 and 3), a new ecdysteroid (4), and four known compounds (5-8), were isolated from the whole plants of Helleborus niger L. (Ranunculaceae). The structures of the new compounds (1-4) were determined by spectroscopic analysis, including 2D NMR spectral data, and hydrolytic studies. Compounds 1-6 showed cytotoxicity against HL-60 human leukemia cells, A549 human lung adenocarcinoma cells, and SBC-3 human small-cell lung cancer cells, with IC
Identifiants
pubmed: 33502658
doi: 10.1007/s11418-021-01481-6
pii: 10.1007/s11418-021-01481-6
doi:
Substances chimiques
Bufanolides
0
Ecdysteroids
0
bufadienolide
29565-35-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
393-402Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18K06735
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