Nicorandil decreases oxidative stress in slow- and fast-twitch muscle fibers of diabetic rats by improving the glutathione system functioning.
Animals
Diabetes Mellitus, Experimental
/ drug therapy
Gene Expression Regulation
/ drug effects
Glutathione
/ drug effects
Lipid Peroxidation
/ drug effects
Male
Muscle Fibers, Fast-Twitch
/ drug effects
Muscle Fibers, Slow-Twitch
/ drug effects
Muscle, Skeletal
/ drug effects
Nicorandil
/ pharmacology
Oxidation-Reduction
/ drug effects
Oxidative Stress
/ drug effects
Rats
Rats, Wistar
Streptozocin
Transcription, Genetic
/ drug effects
Diabetic myopathy
Nicorandil
Oxidative stress
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
20
10
2020
received:
16
06
2020
accepted:
24
01
2021
pubmed:
28
1
2021
medline:
11
11
2021
entrez:
27
1
2021
Statut:
ppublish
Résumé
Myopathy is a common complication of any diabetes type, consisting in failure to preserve mass and muscular function. Oxidative stress has been considered one of the main causes for this condition. This study aimed to search if Nicorandil, a K Diabetes was induced in male Wistar rats by applying intraperitoneally streptozotocin (STZ) at 100 mg/kg doses. Nicorandil (3 mg/kg/day) was administered along 4 weeks. An insulin tolerance test and assessment of fasting blood glucose (FBG), TBARS, reduced (GSH), and disulfide (GSSG) glutathione levels, GSH/GSSG ratio, and mRNA expression of glutathione metabolism-related genes were performed at end of treatment in soleus and gastrocnemius muscles. Nicorandil significantly reduced FBG levels and enhanced insulin tolerance in diabetic rats. In gastrocnemius and soleus muscles, Nicorandil attenuated the oxidative stress by decreasing lipid peroxidation (TBARS), increasing total glutathione and modulating GPX1-mRNA expression in both muscle's types. Nicorandil also increased GSH and GSH/GSSG ratio and downregulated the GCLC- and GSR-mRNA in gastrocnemius, without significative effect on those enzymes' mRNA expression in diabetic soleus muscle. In diabetic rats, Nicorandil attenuates oxidative stress in slow- and fast-twitch skeletal muscles by improving the glutathione system functioning. The underlying mechanisms for the modulation of glutathione redox state and the transcriptional expression of glutathione metabolism-related genes seem to be fiber type-dependent.
Identifiants
pubmed: 33503290
doi: 10.1111/jdi.13513
pmc: PMC8264387
doi:
Substances chimiques
Nicorandil
260456HAM0
Streptozocin
5W494URQ81
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1152-1161Subventions
Organisme : Coordinación de la Investigación Científica, Universidad Michoacana de San Nicolás de Hidalgo
ID : RMP
Organisme : Coordinación de la Investigación Científica, Universidad de Guanajuato
ID : ESD-CIIC-237/2019
Organisme : PRODEP
ID : UGTO-PTC-667
Informations de copyright
© 2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
Références
Eur J Endocrinol. 2004 Aug;151(2):277-85
pubmed: 15296485
J Clin Endocrinol Metab. 2013 May;98(5):2027-36
pubmed: 23515448
Nat Protoc. 2006;1(6):3159-65
pubmed: 17406579
Muscle Nerve. 2001 Mar;24(3):387-93
pubmed: 11353424
Plast Reconstr Surg. 2013 Mar;131(3):473-485
pubmed: 23446562
J Inflamm Res. 2018 Feb 19;11:61-68
pubmed: 29497324
Exp Diabetes Res. 2012;2012:793783
pubmed: 22454629
Biochim Biophys Acta. 2006 May-Jun;1757(5-6):715-20
pubmed: 16787636
Metabolism. 2000 Apr;49(4):427-31
pubmed: 10778863
Free Radic Biol Med. 2012 Dec 1;53(11):2017-27
pubmed: 23022873
World J Diabetes. 2015 Apr 15;6(3):456-80
pubmed: 25897356
Arch Biochem Biophys. 2014 Jan 1;541:47-52
pubmed: 24262853
Diabetes. 2004 Apr;53(4):1082-8
pubmed: 15047625
J Muscle Res Cell Motil. 2015 Dec;36(6):377-93
pubmed: 26728750
Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8852-7
pubmed: 15184668
Rev Med Chil. 2018 Mar;146(3):362-372
pubmed: 29999107
Diabetes. 2002 Jun;51(6):1913-20
pubmed: 12031981
Circ Res. 2004 Mar 5;94(4):420-32
pubmed: 15001541
Basic Res Cardiol. 2007 Jan;102(1):73-9
pubmed: 16900442
FEBS J. 2018 Oct;285(20):3688-3694
pubmed: 29761627
Free Radic Biol Med. 2018 Nov 1;127:108-115
pubmed: 29800654
J Interv Cardiol. 2014 Oct;27(5):472-81
pubmed: 25174952
Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H559-67
pubmed: 15458954
Front Physiol. 2013 Dec 20;4:379
pubmed: 24391596
PLoS One. 2011 Apr 25;6(4):e18922
pubmed: 21541347
Diabetes Care. 1994 Feb;17(2):152-4
pubmed: 8137688
Anatol J Cardiol. 2015 Feb;15(2):125-31
pubmed: 25252296
Diabetes Ther. 2018 Aug;9(4):1421-1429
pubmed: 29869049
J Biol Chem. 2010 May 21;285(21):16116-24
pubmed: 20332089
Circ Res. 2010 Oct 29;107(9):1058-70
pubmed: 21030723
Front Pharmacol. 2014 Aug 26;5:196
pubmed: 25206336
Endocrinology. 2012 May;153(5):2099-111
pubmed: 22396448
Cardiovasc Diabetol. 2011 Nov 23;10:105
pubmed: 22107602
Front Endocrinol (Lausanne). 2018 Jan 24;9:6
pubmed: 29416527
Mol Med Rep. 2014 Jun;9(6):2227-32
pubmed: 24676284
J Clin Diagn Res. 2012 Nov;6(9):1469-73
pubmed: 23285432
Am J Physiol Renal Physiol. 2012 May 1;302(9):F1151-60
pubmed: 22338086
World J Diabetes. 2015 Dec 10;6(17):1323-36
pubmed: 26674848
Saudi Pharm J. 2016 Sep;24(5):547-553
pubmed: 27752226
Biol Chem. 2013 Oct;394(10):1263-80
pubmed: 24002664
J Bioenerg Biomembr. 2017 Apr;49(2):159-170
pubmed: 28054274
J Tradit Complement Med. 2012 Apr;2(2):135-44
pubmed: 24716126
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
J Appl Physiol (1985). 2007 Apr;102(4):1664-70
pubmed: 17082364
Eur J Pharmacol. 2015 Feb 5;748:123-32
pubmed: 25542756
J Physiol. 2011 May 1;589(Pt 9):2119-27
pubmed: 21041533
J Clin Med. 2019 Sep 04;8(9):
pubmed: 31487953
Nutrients. 2019 Sep 30;11(10):
pubmed: 31575008
Circ J. 2009 Mar;73(3):554-61
pubmed: 19179768
Indian J Pharmacol. 2019 Sep-Oct;51(5):296-301
pubmed: 31831918
Basic Clin Pharmacol Toxicol. 2013 Sep;113(3):158-66
pubmed: 23621757
Acta Physiol Hung. 2014 Dec;101(4):421-8
pubmed: 25201710
Diabetes Care. 2011 Jan;34(1):162-7
pubmed: 20929994
Diabetes. 2011 Jul;60(7):1964-72
pubmed: 21593201
J Biol Chem. 1949 Feb;177(2):751-66
pubmed: 18110453
Biomed Res Int. 2015;2015:592915
pubmed: 26075247
J Clin Endocrinol Metab. 2012 Jul;97(7):E1182-6
pubmed: 22496506
J Cardiovasc Pharmacol Ther. 2016 Nov;21(6):549-562
pubmed: 26940570
Oxid Med Cell Longev. 2016;2016:6978625
pubmed: 27579154
Med Sci Monit Basic Res. 2018 Sep 28;24:141-145
pubmed: 30262799
Nat Protoc. 2006;1(2):581-5
pubmed: 17406285