Risk of breast cancer associated with long-term exposure to benzo[a]pyrene (BaP) air pollution: Evidence from the French E3N cohort study.

Air Pollution / adverse effects Benzo(a)pyrene / toxicity Breast Neoplasms / chemically induced Case-Control Studies Cohort Studies Female Humans Risk Factors
Airborne benzo[a]pyrene Breast cancer Differentiation grade Hormone receptor status Menopausal transition Residential history

Journal

Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270

Informations de publication

Date de publication:
04 2021
Historique:
received: 13 08 2020
revised: 11 01 2021
accepted: 12 01 2021
pubmed: 28 1 2021
medline: 27 4 2021
entrez: 27 1 2021
Statut: ppublish

Résumé

Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive and developmental toxicant, however epidemiological evidence of the long-term effect of ambient air BaP on breast cancer (BC) is limited. Thus we evaluated associations between ambient air BaP exposure and risk of BC, overall and according to menopausal status and molecular subtypes (estrogen receptor negative/positive (ER-/ER+) and progesterone receptor negative/positive (PR-/PR+)), stage and grade of differentiation of BC in the French E3N cohort study. Within a nested case-control study of 5222 incident BC cases and 5222 matched controls, annual BaP exposure was estimated using a chemistry-transport model (CHIMERE) and was assigned to the geocoded residential addresses of participants for each year during the 1990-2011 follow-up period. Multivariable conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Overall, cumulative airborne BaP exposure was significantly associated with the overall risk of BC, for each 1 interquartile range (IQR) increase in the concentration levels of BaP (1.42 ng/m We provide evidence of increased risk of BC associated with cumulative BaP exposure, which varied according to menopausal status, hormone receptor status, and grade of differentiation of BC. Our results add further epidemiological evidence to the previous experimental studies suggesting the adverse effects of BaP.

Sections du résumé

BACKGROUND
Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive and developmental toxicant, however epidemiological evidence of the long-term effect of ambient air BaP on breast cancer (BC) is limited. Thus we evaluated associations between ambient air BaP exposure and risk of BC, overall and according to menopausal status and molecular subtypes (estrogen receptor negative/positive (ER-/ER+) and progesterone receptor negative/positive (PR-/PR+)), stage and grade of differentiation of BC in the French E3N cohort study.
METHODS
Within a nested case-control study of 5222 incident BC cases and 5222 matched controls, annual BaP exposure was estimated using a chemistry-transport model (CHIMERE) and was assigned to the geocoded residential addresses of participants for each year during the 1990-2011 follow-up period. Multivariable conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS
Overall, cumulative airborne BaP exposure was significantly associated with the overall risk of BC, for each 1 interquartile range (IQR) increase in the concentration levels of BaP (1.42 ng/m
CONCLUSIONS
We provide evidence of increased risk of BC associated with cumulative BaP exposure, which varied according to menopausal status, hormone receptor status, and grade of differentiation of BC. Our results add further epidemiological evidence to the previous experimental studies suggesting the adverse effects of BaP.

Identifiants

DOI: 10.1016/j.envint.2021.106399 PMID: 33503556
pubmed: 33503556
pii: S0160-4120(21)00023-4
doi: 10.1016/j.envint.2021.106399
pii:
doi:

Substances chimiques

Benzo(a)pyrene 3417WMA06D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106399

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Amina Amadou (A)

Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France; Inserm UMR 1296 Radiations : Défense, Santé, Environnement, Lyon, France.

Delphine Praud (D)

Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France; Inserm UMR 1296 Radiations : Défense, Santé, Environnement, Lyon, France.

Thomas Coudon (T)

Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France; Inserm UMR 1296 Radiations : Défense, Santé, Environnement, Lyon, France; Ecole Centrale de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, Ecully, France.

Floriane Deygas (F)

Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France; Inserm UMR 1296 Radiations : Défense, Santé, Environnement, Lyon, France.

Leny Grassot (L)

Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France; Inserm UMR 1296 Radiations : Défense, Santé, Environnement, Lyon, France.

Elodie Faure (E)

Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France; Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine, Université Paris-Saclay, UPS UVSQ, Gustave Roussy, Villejuif, France.

Florian Couvidat (F)

National Institute for Industrial Environment and Risks (INERIS), Verneuil-en-Halatte, France.

Julien Caudeville (J)

National Institute for Industrial Environment and Risks (INERIS), Verneuil-en-Halatte, France.

Bertrand Bessagnet (B)

National Institute for Industrial Environment and Risks (INERIS), Verneuil-en-Halatte, France; Citepa, Technical Reference Center for Air Pollution and Climate Change, Paris, France.

Pietro Salizzoni (P)

Ecole Centrale de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, Ecully, France.

John Gulliver (J)

Centre for Environmental Health and Sustainability, School of Geography, Geology and the Environment, University of Leicester, United Kingdom.

Karen Leffondré (K)

Université de Bordeaux, ISPED, Inserm U1219, Bordeaux Population Health Center, Bordeaux, France.

Gianluca Severi (G)

Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine, Université Paris-Saclay, UPS UVSQ, Gustave Roussy, Villejuif, France; Departement of Statistics, Computer Science and Applications (DISIA), University of Florence, Italy.

Francesca Romana Mancini (FR)

Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine, Université Paris-Saclay, UPS UVSQ, Gustave Roussy, Villejuif, France. Electronic address: Francesca.MANCINI@gustaveroussy.fr.

Béatrice Fervers (B)

Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France; Inserm UMR 1296 Radiations : Défense, Santé, Environnement, Lyon, France. Electronic address: beatrice.fervers@lyon.unicancer.fr.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution de l'air › Risk of breast cancer associated with...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Pyrènes › Benzopyrènes › Benzo[a]pyrène › Risk of breast cancer associated with...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Risk of breast cancer associated with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Risk of breast cancer associated with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Risk of breast cancer associated with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Risk of breast cancer associated with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Risk of breast cancer associated with...