Optic neuropathy secondary to perhexiline and amiodarone.
cardiovascular system
neuroopthalmology
unwanted effects / adverse reactions
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
27 Jan 2021
27 Jan 2021
Historique:
entrez:
28
1
2021
pubmed:
29
1
2021
medline:
24
2
2021
Statut:
epublish
Résumé
Bilateral optic disc swelling is an important clinical sign for potentially life-threatening and sight-threatening conditions, with the most common being raised intracranial pressure and pseudopapillitis. Perhexiline-related and amiodarone-related optic disc swellings are diagnoses of exclusion. This report describes the diagnosis of a man with perhexiline-induced and amiodarone-induced optic neuropathy after extensive investigation consisting of full ophthalmic examination, biochemical screen, temporal artery biopsy, CT, MRI, positron emission tomography and lumbar puncture. There was partial to complete resolution of optic neuropathy following cessation of the causative medication. We postulate that the underlying mechanism of perhexiline toxicity could be mitochondrial dysfunction related. Our case demonstrates that patients treated with perhexiline and amiodarone should be monitored closely for ocular side effects.
Identifiants
pubmed: 33504523
pii: 14/1/e237727
doi: 10.1136/bcr-2020-237727
pmc: PMC7843302
pii:
doi:
Substances chimiques
Vasodilator Agents
0
Perhexiline
KU65374X44
Amiodarone
N3RQ532IUT
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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