The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer.
Adoptive Transfer
/ methods
Animals
Antigens, Surface
/ immunology
CD3 Complex
/ antagonists & inhibitors
Cell Line, Tumor
Cytokines
/ metabolism
Cytotoxicity, Immunologic
Disease Models, Animal
Dose-Response Relationship, Immunologic
Glutamate Carboxypeptidase II
/ antagonists & inhibitors
Humans
Lymphocyte Activation
/ immunology
Male
Mice
Prostatic Neoplasms, Castration-Resistant
/ drug therapy
T-Lymphocytes
/ immunology
Treatment Outcome
Xenograft Model Antitumor Assays
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 05 2021
15 05 2021
Historique:
received:
20
09
2020
revised:
11
12
2020
accepted:
25
01
2021
pubmed:
29
1
2021
medline:
17
3
2022
entrez:
28
1
2021
Statut:
ppublish
Résumé
Metastatic castration-resistant prostate cancer (mCRPC) remains a disease with high unmet medical need, as most patients do not achieve durable response with available treatments. Prostate-specific membrane antigen (PSMA) is a compelling target for mCRPC. It is highly expressed by primary and metastatic prostate cancer cells, with increased expression after progression on androgen deprivation therapy. We developed AMG 160, a half-life extended, bispecific T-cell engager immuno-oncology therapy that binds PSMA on prostate cancer cells and cluster of differentiation 3 on T cells for treatment of mCRPC. AMG 160 was evaluated AMG 160 induces potent, specific killing of PSMA-expressing prostate cancer cell lines The preclinical characterization of AMG 160 highlights its potent antitumor activity
Identifiants
pubmed: 33504551
pii: 1078-0432.CCR-20-3725
doi: 10.1158/1078-0432.CCR-20-3725
doi:
Substances chimiques
Antigens, Surface
0
CD3 Complex
0
Cytokines
0
FOLH1 protein, human
EC 3.4.17.21
Glutamate Carboxypeptidase II
EC 3.4.17.21
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2928-2937Commentaires et corrections
Type : CommentIn
Informations de copyright
©2021 American Association for Cancer Research.
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