Association of Dilated Perivascular Spaces With Cognitive Decline and Incident Dementia.

Aged Aged, 80 and over Cognitive Dysfunction / pathology Dementia / pathology Disease Progression Female Glymphatic System / pathology Humans Longitudinal Studies Male

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
16 03 2021
Historique:
received: 16 02 2020
accepted: 08 12 2020
pubmed: 29 1 2021
medline: 27 3 2021
entrez: 28 1 2021
Statut: ppublish

Résumé

To determine whether severe perivascular space (PVS) dilation is associated with longitudinal cognitive decline and incident dementia over 4 and 8 years, respectively, we analyzed data from a prospective cohort study. A total of 414 community-dwelling older adults aged 72-92 years were assessed at baseline and biennially for up to 8 years, with cognitive assessments, consensus dementia diagnoses, and 3T MRI. The numbers of PVS in 2 representative slices in the basal ganglia (BG) and centrum semiovale (CSO) were counted and severe PVS pathology defined as the top quartile. The effects of severe PVS pathology in either region or both regions and those with severe BG PVS and severe CSO PVS were examined. White matter hyperintensity volume, cerebral microbleed number, and lacune number were calculated. Participants with severe PVS pathology in both regions or in the CSO alone had greater decline in global cognition over 4 years, even after adjustment for the presence of other small vessel disease neuroimaging markers. The presence of severe PVS pathology in both regions was an independent predictor of dementia across 8 years (odds ratio 2.91, 95% confidence interval 1.43-5.95, Severe PVS pathology is a marker for increased risk of cognitive decline and dementia, independent of other small vessel disease markers. The differential cognitive associations for BG and CSO PVS may represent differences in their underlying pathology.

Identifiants

DOI: 10.1212/WNL.0000000000011537 PMID: 33504642 PMC: PMC8032377
pubmed: 33504642
pii: WNL.0000000000011537
doi: 10.1212/WNL.0000000000011537
pmc: PMC8032377
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1501-e1511

Informations de copyright

© 2021 American Academy of Neurology.

Références

Lancet Neurol. 2013 Aug;12(8):822-38
pubmed: 23867200
Clin Sci (Lond). 2017 Aug 10;131(17):2257-2274
pubmed: 28798076
Stroke. 2010 Nov;41(11):2483-90
pubmed: 20864661
J Alzheimers Dis. 2010;22(2):663-72
pubmed: 20847444
Aging Clin Exp Res. 2019 Sep;31(9):1283-1297
pubmed: 30535620
J Clin Epidemiol. 2005 Jan;58(1):13-9
pubmed: 15649666
Neurology. 2018 Aug 28;91(9):e832-e842
pubmed: 30068634
J Am Heart Assoc. 2017 Sep 22;6(9):
pubmed: 28939709
Cerebrovasc Dis. 2015;39(3-4):224-31
pubmed: 25823458
J Clin Epidemiol. 2008 Apr;61(4):344-9
pubmed: 18313558
Stroke. 2010 Mar;41(3):450-4
pubmed: 20056930
Cardiovasc Res. 2018 Sep 1;114(11):1462-1473
pubmed: 29726891
Int J Stroke. 2019 Jun;14(4):359-371
pubmed: 30762496
Acta Neuropathol. 2018 Mar;135(3):387-407
pubmed: 29428972
Neuroimage. 2018 Jul 1;174:539-549
pubmed: 29578029
J Neurol Sci. 2020 Feb 15;409:116621
pubmed: 31945583
Neurology. 2014 Dec 2;83(23):2116-23
pubmed: 25361776
Int Psychogeriatr. 2010 Dec;22(8):1248-64
pubmed: 20637138
Int J Stroke. 2018 Jan;13(1):47-56
pubmed: 27543501
Stroke. 2018 Mar;49(3):586-593
pubmed: 29438074
J Alzheimers Dis. 2015;43(2):415-24
pubmed: 25096616
Neurology. 2013 Apr 23;80(17):1551-6
pubmed: 23553482
JAMA Neurol. 2017 Sep 1;74(9):1105-1112
pubmed: 28715552
AJNR Am J Neuroradiol. 1989 Sep-Oct;10(5):929-36
pubmed: 2505536
Brain Imaging Behav. 2019 Jun;13(3):750-761
pubmed: 29802601
AJNR Am J Neuroradiol. 2011 Apr;32(4):709-13
pubmed: 21349956
Neuroimage. 2004 May;22(1):144-54
pubmed: 15110004
Brain. 2017 Apr 1;140(4):1107-1116
pubmed: 28335021
Neurology. 2014 Jan 7;82(1):57-62
pubmed: 24285616
J Neurol. 2008 May;255(5):692-6
pubmed: 18286319
J Alzheimers Dis. 2019;72(1):247-256
pubmed: 31561362
J Neurol Neurosurg Psychiatry. 2014 May;85(5):522-5
pubmed: 24249785

Auteurs

Matthew Paradise (M)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia. z3495052@ad.unsw.edu.au.
ORCID: 0000-0003-4002-9599

John D Crawford (JD)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.

Ben C P Lam (BCP)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.

Wei Wen (W)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.
ORCID: 0000-0003-2753-3870

Nicole A Kochan (NA)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.

Steve Makkar (S)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.

Laughlin Dawes (L)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.

Julian Trollor (J)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.
ORCID: 0000-0002-7685-2977

Brian Draper (B)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.

Henry Brodaty (H)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.

Perminder S Sachdev (PS)

From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.
ORCID: 0000-0002-9595-3220

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Association of Dilated Perivascular Spaces...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Association of Dilated Perivascular Spaces...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Association of Dilated Perivascular Spaces...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Association of Dilated Perivascular Spaces...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Association of Dilated Perivascular Spaces...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Système glymphatique › Association of Dilated Perivascular Spaces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of Dilated Perivascular Spaces...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Association of Dilated Perivascular Spaces...