Evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study.
Aged
Aged, 80 and over
Angiotensin Receptor Antagonists
/ therapeutic use
Blood Pressure
/ physiology
Carotid Arteries
/ physiopathology
Carotid Artery Diseases
/ physiopathology
Constriction, Pathologic
/ physiopathology
Cross-Sectional Studies
Female
Glycated Hemoglobin
/ metabolism
Humans
Male
Middle Aged
Multivariate Analysis
Prospective Studies
Risk Factors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 01 2021
27 01 2021
Historique:
received:
04
07
2020
accepted:
28
12
2020
entrez:
28
1
2021
pubmed:
29
1
2021
medline:
30
10
2021
Statut:
epublish
Résumé
MRI can assess plaque composition and has demonstrated an association between some atherosclerotic risk factors (RF) and markers of plaque vulnerability in naive patients. We aimed at investigating this association in medically treated asymptomatic patients. This is a cross-sectional interim analysis (August 2013-September 2016) of a single center prospective study on carotid plaque vulnerability (MAGNETIC study). We recruited patients with asymptomatic carotid atherosclerosis (US stenosis > 30%, ECST criteria), receiving medical treatments at a tertiary cardiac rehabilitation. Atherosclerotic burden and plaque composition were quantified with 3.0 T MRI. The association between baseline characteristics and extent of lipid-rich necrotic core (LRNC), fibrous cap (CAP) and intraplaque hemorrhage (IPH) was studied with multiple regression analysis. We enrolled 260 patients (198 male, 76%) with median age of 71-y (interquartile range: 65-76). Patients were on antiplatelet therapy, ACE-inhibitors/angiotensin receptor blockers and statins (196-229, 75-88%). Median LDL-cholesterol was 78 mg/dl (59-106), blood pressure 130/70 mmHg (111-140/65-80), glycosylated hemoglobin 46 mmol/mol (39-51) and BMI 25 kg/m
Identifiants
pubmed: 33504842
doi: 10.1038/s41598-021-81247-y
pii: 10.1038/s41598-021-81247-y
pmc: PMC7840938
doi:
Substances chimiques
Angiotensin Receptor Antagonists
0
Glycated Hemoglobin A
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2327Références
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