Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury.

Animals Baroreflex Biomimetics Disease Models, Animal Female Hemodynamics Humans Male Neural Pathways Primates Prostheses and Implants Rats Rats, Inbred Lew Spinal Cord Injuries / physiopathology Sympathetic Nervous System / cytology

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2021
Historique:
received: 07 05 2020
accepted: 11 12 2020
pubmed: 29 1 2021
medline: 10 3 2021
entrez: 28 1 2021
Statut: ppublish

Résumé

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival

Identifiants

DOI: 10.1038/s41586-020-03180-w PMID: 33505019
pubmed: 33505019
doi: 10.1038/s41586-020-03180-w
pii: 10.1038/s41586-020-03180-w
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

308-314

Subventions

Organisme : European Research Council
Pays : International

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Références

Squair, J. W., Phillips, A. A., Harmon, M. & Krassioukov, A. V. Emergency management of autonomic dysreflexia with neurologic complications. Can. Med. Assoc. J. 188, 1100–1103 (2016).
doi: 10.1503/cmaj.151311
Readdy, W. J. et al. Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome. J. Neurosurg. Spine 23, 574–580 (2015).
pubmed: 26230417 doi: 10.3171/2015.2.SPINE14746
Inoue, T., Manley, G. T., Patel, N. & Whetstone, W. D. Medical and surgical management after spinal cord injury: vasopressor usage, early surgerys, and complications. J. Neurotrauma 31, 284–291 (2014).
pubmed: 24020382 doi: 10.1089/neu.2013.3061
Squair, J. W. et al. Spinal cord perfusion pressure predicts neurologic recovery in acute spinal cord injury. Neurology 89, 1660–1667 (2017).
pubmed: 28916535 doi: 10.1212/WNL.0000000000004519
Squair, J. W. et al. Empirical targets for acute haemodynamic management of individuals with spinal cord injury. Neurology 93, e1205–e1211 (2019).
pubmed: 31409736 doi: 10.1212/WNL.0000000000008125
Cragg, J. J., Noonan, V. K., Krassioukov, A. & Borisoff, J. Cardiovascular disease and spinal cord injury: results from a national population health survey. Neurology 81, 723–728 (2013).
pubmed: 23884034 pmcid: 3776463 doi: 10.1212/WNL.0b013e3182a1aa68
Wu, J.-C. et al. Increased risk of stroke after spinal cord injury: a nationwide 4-year follow-up cohort study. Neurology 78, 1051–1057 (2012).
pubmed: 22377807 doi: 10.1212/WNL.0b013e31824e8eaa
Illman, A., Stiller, K. & Williams, M. The prevalence of orthostatic hypotension during physiotherapy treatment in patients with an acute spinal cord injury. Spinal Cord 38, 741–747 (2000).
doi: 10.1038/sj.sc.3101089
Carlozzi, N. E. et al. Impact of blood pressure dysregulation on health-related quality of life in persons with spinal cord injury: development of a conceptual model. Arch. Phys. Med. Rehabil. 94, 1721–1730 (2013).
pubmed: 23499779 pmcid: 4342994 doi: 10.1016/j.apmr.2013.02.024
Furlan, J. C., Fehlings, M. G., Shannon, P., Norenberg, M. D. & Krassioukov, A. V. Descending vasomotor pathways in humans: correlation between axonal preservation and cardiovascular dysfunction after spinal cord injury. J. Neurotrauma 20, 1351–1363 (2003).
pubmed: 14748983 doi: 10.1089/089771503322686148
Capogrosso, M. et al. A brain-spine interface alleviating gait deficits after spinal cord injury in primates. Nature 539, 284–288 (2016).
pubmed: 27830790 pmcid: 5108412 doi: 10.1038/nature20118
Wagner, F. B. et al. Targeted neurotechnology restores walking in humans with spinal cord injury. Nature 563, 65–71 (2018).
pubmed: 30382197 doi: 10.1038/s41586-018-0649-2
Saadoun, S., Chen, S. & Papadopoulos, M. C. Intraspinal pressure and spinal cord perfusion pressure predict neurological outcome after traumatic spinal cord injury. J. Neurol. Neurosurg. Psychiatry 88, 452–453 (2016).
pubmed: 27864426 doi: 10.1136/jnnp-2016-314600
Vale, F. L., Burns, J., Jackson, A. B. & Hadley, M. N. Combined medical and surgical treatment after acute spinal cord injury: results of a prospective pilot study to assess the merits of aggressive medical resuscitation and blood pressure management. J. Neurosurg. 87, 239–246 (1997).
pubmed: 9254087 doi: 10.3171/jns.1997.87.2.0239
Rawlings, A. M. et al. Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline. Neurology 91, e759–e768 (2018).
pubmed: 30045960 pmcid: 6107267 doi: 10.1212/WNL.0000000000006027
Phillips, A. A., Krassioukov, A. V., Ainslie, P. N. & Warburton, D. E. R. Baroreflex function after spinal cord injury. J. Neurotrauma 29, 2431–2445 (2012).
pubmed: 22897489 doi: 10.1089/neu.2012.2507
Phillips, A. A., Krassioukov, A. V., Ainslie, P. N. & Warburton, D. E. R. Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine. J. Appl. Physiol. 116, 645–653 (2014).
pubmed: 24436297 pmcid: 3949242 doi: 10.1152/japplphysiol.01090.2013
Courtine, G. et al. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nat. Neurosci. 12, 1333–1342 (2009).
pubmed: 19767747 pmcid: 2828944 doi: 10.1038/nn.2401
Angeli, C. A. et al. Recovery of over-ground walking after chronic motor complete spinal cord injury. N. Engl. J. Med. 379, 1244–1250 (2018).
pubmed: 30247091 doi: 10.1056/NEJMoa1803588
Gill, M. L. et al. Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia. Nat. Med. 24, 1677–1682 (2018).
pubmed: 30250140 doi: 10.1038/s41591-018-0175-7
Wenger, N. et al. Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury. Nat. Med. 22, 138–145 (2016).
pubmed: 26779815 pmcid: 5061079 doi: 10.1038/nm.4025
West, C. R. et al. Association of epidural stimulation with cardiovascular function in an individual with spinal cord injury. JAMA Neurol. 75, 630–632 (2018).
pubmed: 29459943 doi: 10.1001/jamaneurol.2017.5055
Harkema, S. J. et al. Epidural spinal cord stimulation training and sustained recovery of cardiovascular function in individuals with chronic cervical spinal cord injury. JAMA Neurol. 75, 1569–1571 (2018).
pubmed: 30242310 pmcid: 6583212 doi: 10.1001/jamaneurol.2018.2617
Harkema, S. J. et al. Normalization of blood pressure with spinal cord epidural stimulation after severe spinal cord injury. Front. Hum. Neurosci. 12, 83 (2018).
pubmed: 29568266 pmcid: 5852107 doi: 10.3389/fnhum.2018.00083
Darrow, D. et al. Epidural spinal cord stimulation facilitates immediate restoration of dormant motor and autonomic supraspinal pathways after chronic neurologically complete spinal cord injury. J. Neurotrauma 36, 2325–2336 (2019).
pubmed: 30667299 pmcid: 6648195 doi: 10.1089/neu.2018.6006
Grimm, D. et al. In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. J. Virol. 82, 5887–5911 (2008).
pubmed: 18400866 pmcid: 2395137 doi: 10.1128/JVI.00254-08
Witten, I. B. et al. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron 72, 721–733 (2011).
pubmed: 22153370 pmcid: 3282061 doi: 10.1016/j.neuron.2011.10.028
Tomer, R., Ye, L., Hsueh, B. & Deisseroth, K. Advanced CLARITY for rapid and high-resolution imaging of intact tissues. Nat. Protocols 9, 1682–1697 (2014).
pubmed: 24945384 doi: 10.1038/nprot.2014.123
Strack, A. M., Sawyer, W. B., Marubio, L. M. & Loewy, A. D. Spinal origin of sympathetic preganglionic neurons in the rat. Brain Res. 455, 187–191 (1988).
pubmed: 3416186 doi: 10.1016/0006-8993(88)90132-1
Capogrosso, M. et al. A computational model for epidural electrical stimulation of spinal sensorimotor circuits. J. Neurosci. 33, 19326–19340 (2013).
pubmed: 24305828 pmcid: 6618777 doi: 10.1523/JNEUROSCI.1688-13.2013
Gradinaru, V., Thompson, K. R. & Deisseroth, K. eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol. 36, 129–139 (2008).
pubmed: 18677566 pmcid: 2588488 doi: 10.1007/s11068-008-9027-6
Phillips, A. A., Elliott, S. L., Zheng, M. M. Z. & Krassioukov, A. V. Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury. J. Neurotrauma 32, 392–396 (2015).
pubmed: 25093677 doi: 10.1089/neu.2014.3590
Beauparlant, J. et al. Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury. Brain 136, 3347–3361 (2013).
pubmed: 24080153 doi: 10.1093/brain/awt204
Minev, I. R. et al. Biomaterials. Electronic dura mater for long-term multimodal neural interfaces. Science 347, 159–163 (2015).
pubmed: 25574019 doi: 10.1126/science.1260318
Formento, E. et al. Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury. Nat. Neurosci. 21, 1728–1741 (2018).
pubmed: 30382196 pmcid: 6268129 doi: 10.1038/s41593-018-0262-6
Cornwell, W. K. III et al. Restoration of pulsatile flow reduces sympathetic nerve activity among individuals with continuous-flow left ventricular assist devices. Circulation 132, 2316–2322 (2015).
pubmed: 26510698 doi: 10.1161/CIRCULATIONAHA.115.017647
Purohit, S. N., Cornwell, W. K. III, Pal, J. D., Lindenfeld, J. & Ambardekar, A. V. Living without a pulse: the vascular implications of continuous-flow left ventricular assist devices. Circ. Heart Fail. 11, e004670 (2018).
pubmed: 29903893 pmcid: 6007027 doi: 10.1161/CIRCHEARTFAILURE.117.004670
Cheng, A., Williamitis, C. A. & Slaughter, M. S. Comparison of continuous-flow and pulsatile-flow left ventricular assist devices: is there an advantage to pulsatility? Ann. Cardiothorac. Surg. 3, 573–581 (2014).
pubmed: 25512897 pmcid: 4250555
Saleem, S. et al. Wavelet decomposition analysis is a clinically relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury. Am. J. Physiol. Heart Circ. Physiol. 314, H1108–H1114 (2018).
pubmed: 29600896 pmcid: 6008151 doi: 10.1152/ajpheart.00152.2017
Phillips, A. A., Warburton, D. E. R., Ainslie, P. N. & Krassioukov, A. V. Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride. J. Cereb. Blood Flow Metab. 34, 794–801 (2014).
pubmed: 24473484 pmcid: 4013775 doi: 10.1038/jcbfm.2014.3
Courtine, G. & Bloch, J. Defining ecological strategies in neuroprosthetics. Neuron 86, 29–33 (2015).
pubmed: 25856483 doi: 10.1016/j.neuron.2015.02.039
Phillips, A. A. & Krassioukov, A. V. Contemporary cardiovascular concerns after spinal cord injury: mechanisms, maladaptations, and management. J. Neurotrauma 32, 1927–1942 (2015).
pubmed: 25962761 doi: 10.1089/neu.2015.3903
Phillips, A. A. & Krassioukov, A. V. in Neurological Aspects of Spinal Cord Injury (eds Weidner, N. et al.) 325–361 (Springer International Publishing, 2017).
Richardson, R. R., Cerullo, L. J. & Meyer, P. R. Autonomic hyper-reflexia modulated by percutaneous epidural neurostimulation: a preliminary report. Neurosurgery 4, 517–520 (1979).
pubmed: 314604 doi: 10.1227/00006123-197906000-00004
Ramsey, J. B. G. et al. Care of rats with complete high-thoracic spinal cord injury. J. Neurotrauma 27, 1709–1722 (2010).
pubmed: 20597687 doi: 10.1089/neu.2010.1382
Anderson, M. A. et al. Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature 561, 396–400 (2018).
pubmed: 30158698 pmcid: 6151128 doi: 10.1038/s41586-018-0467-6
Squair, J. W. et al. High thoracic contusion model for the investigation of cardiovascular function after spinal cord injury. J. Neurotrauma 34, 671–684 (2016).
pubmed: 27456150 doi: 10.1089/neu.2016.4518
Asboth, L. et al. Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion. Nat. Neurosci. 21, 576–588 (2018).
pubmed: 29556028 doi: 10.1038/s41593-018-0093-5
Scheff, S. W., Rabchevsky, A. G., Fugaccia, I., Main, J. A. & Lumpp, J. E., Jr. Experimental modeling of spinal cord injury: characterization of a force-defined injury device. J. Neurotrauma 20, 179–193 (2003).
pubmed: 12675971 doi: 10.1089/08977150360547099
van den Brand, R. et al. Restoring voluntary control of locomotion after paralyzing spinal cord injury. Science 336, 1182–1185 (2012).
pubmed: 22654062 doi: 10.1126/science.1217416
Krassioukov, A. V. & Weaver, L. C. Connections between the pontine reticular formation and rostral ventrolateral medulla. Am. J. Physiol. 265, H1386–H1392 (1993).
pubmed: 8238426
Ueno, M., Ueno-Nakamura, Y., Niehaus, J., Popovich, P. G. & Yoshida, Y. Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury. Nat. Neurosci. 19, 784–787 (2016).
pubmed: 27089020 pmcid: 4882232 doi: 10.1038/nn.4289
Sundt, D., Gamper, N. & Jaffe, D. B. Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study. J. Neurophysiol. 114, 3140–3153 (2015).
pubmed: 26334005 pmcid: 4686302 doi: 10.1152/jn.00226.2015
McIntyre, C. C. & Grill, W. M. Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output. J. Neurophysiol. 88, 1592–1604 (2002).
pubmed: 12364490 doi: 10.1152/jn.2002.88.4.1592
Pan, C. et al. Shrinkage-mediated imaging of entire organs and organisms using uDISCO. Nat. Methods 13, 859–867 (2016).
pubmed: 27548807 doi: 10.1038/nmeth.3964
Lee, E. et al. ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging. Sci. Rep. 6, 18631 (2016).
pubmed: 26750588 pmcid: 4707495 doi: 10.1038/srep18631
Bria, A. & Iannello, G. TeraStitcher - a tool for fast automatic 3D-stitching of teravoxel-sized microscopy images. BMC Bioinformatics 13, 316 (2012).
pubmed: 23181553 pmcid: 3582611 doi: 10.1186/1471-2105-13-316
Rizk, A. et al. Segmentation and quantification of subcellular structures in fluorescence microscopy images using Squassh. Nat. Protocols 9, 586–596 (2014).
pubmed: 24525752 doi: 10.1038/nprot.2014.037
Kirshblum, S. C. et al. International standards for neurological classification of spinal cord injury (revised 2011). J. Spinal Cord Med. 34, 535–546 (2011).
pubmed: 22330108 pmcid: 3232636 doi: 10.1179/204577211X13207446293695
Bogert, L. W. J. & van Lieshout, J. J. Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger. Exp. Physiol. 90, 437–446 (2005).
pubmed: 15802289 doi: 10.1113/expphysiol.2005.030262
Jansen, J. R. et al. A comparison of cardiac output derived from the arterial pressure wave against thermodilution in cardiac surgery patients. Br. J. Anaesth. 87, 212–222 (2001).
pubmed: 11493492 doi: 10.1093/bja/87.2.212
Westerhof, B. E., Gisolf, J., Stok, W. J., Wesseling, K. H. & Karemaker, J. M. Time-domain cross-correlation baroreflex sensitivity: performance on the EUROBAVAR data set. J. Hypertens. 22, 1371–1380 (2004).
pubmed: 15201554 doi: 10.1097/01.hjh.0000125439.28861.ed
Wieling, W., Ganzeboom, K. S. & Saul, J. P. Reflex syncope in children and adolescents. Heart 90, 1094–1100 (2004).
pubmed: 15310717 pmcid: 1768435 doi: 10.1136/hrt.2003.022996
Whinnett, Z. I. et al. Multicenter randomized controlled crossover trial comparing haemodynamic optimization against echocardiographic optimization of av and VV delay of cardiac resynchronization therapy: the BRAVO trial. JACC Cardiovasc. Imaging 12, 1407–1416 (2019).
pubmed: 29778861 pmcid: 6682561 doi: 10.1016/j.jcmg.2018.02.014
Notay, K. et al. Validity and reliability of measuring resting muscle sympathetic nerve activity using short sampling durations in healthy humans. J. Appl. Physiol. 121, 1065–1073 (2016).
pubmed: 27687563 pmcid: 5142246 doi: 10.1152/japplphysiol.00736.2016
Incognito, A. V. et al. Evidence for differential control of muscle sympathetic single units during mild sympathoexcitation in young, healthy humans. Am. J. Physiol. Heart Circ. Physiol. 316, H13–H23 (2019).
pubmed: 30388036 doi: 10.1152/ajpheart.00675.2018
Wallin, B. G. et al. Sympathetic single axonal discharge after spinal cord injury in humans: activity at rest and after bladder stimulation. Spinal Cord 52, 434–438 (2014).
pubmed: 24663001 doi: 10.1038/sc.2014.35
Incognito, A. V. et al. Pharmacological assessment of the arterial baroreflex in a young healthy obese male with extremely low baseline muscle sympathetic nerve activity. Clin. Auton. Res. 28, 593–595 (2018).
pubmed: 30128682 doi: 10.1007/s10286-018-0559-2

Auteurs

Jordan W Squair (JW)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Department of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Department of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
MD/PhD Training Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.
RestoreNetwork, Hotchkiss Brain Institute, Libin Cardiovascular Institute, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
ORCID: 0000-0003-0551-859X

Matthieu Gautier (M)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
ORCID: 0000-0003-4910-8576

Lois Mahe (L)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Jan Elaine Soriano (JE)

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
RestoreNetwork, Hotchkiss Brain Institute, Libin Cardiovascular Institute, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Andreas Rowald (A)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Arnaud Bichat (A)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Newton Cho (N)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Department of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.

Mark A Anderson (MA)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Nicholas D James (ND)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Jerome Gandar (J)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Anthony V Incognito (AV)

RestoreNetwork, Hotchkiss Brain Institute, Libin Cardiovascular Institute, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.

Giuseppe Schiavone (G)

Centre for Neuroprosthetics, Institute of Microengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
ORCID: 0000-0001-7121-9825

Zoe K Sarafis (ZK)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
ORCID: 0000-0003-4149-1099

Achilleas Laskaratos (A)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
ORCID: 0000-0002-2456-5781

Kay Bartholdi (K)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Robin Demesmaeker (R)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
ORCID: 0000-0003-0856-0929

Salif Komi (S)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Charlotte Moerman (C)

Department of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Bita Vaseghi (B)

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Berkeley Scott (B)

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
RestoreNetwork, Hotchkiss Brain Institute, Libin Cardiovascular Institute, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Ryan Rosentreter (R)

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
RestoreNetwork, Hotchkiss Brain Institute, Libin Cardiovascular Institute, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Claudia Kathe (C)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
ORCID: 0000-0001-6441-1755

Jimmy Ravier (J)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Laura McCracken (L)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Xiaoyang Kang (X)

Centre for Neuroprosthetics, Institute of Microengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.

Nicolas Vachicouras (N)

Centre for Neuroprosthetics, Institute of Microengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
ORCID: 0000-0001-5073-2312

Florian Fallegger (F)

Centre for Neuroprosthetics, Institute of Microengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.

Ileana Jelescu (I)

Center for Biomedical Imaging, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
ORCID: 0000-0002-3664-0195

YunLong Cheng (Y)

Motac Neuroscience Ltd, Manchester, UK.

Qin Li (Q)

Motac Neuroscience Ltd, Manchester, UK.

Rik Buschman (R)

Medtronic, Minneapolis, MN, USA.

Nicolas Buse (N)

Medtronic, Minneapolis, MN, USA.

Tim Denison (T)

Department of Engineering Science and Clinical Neurosciences, University of Oxford, Oxford, UK.
Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Sean Dukelow (S)

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
RestoreNetwork, Hotchkiss Brain Institute, Libin Cardiovascular Institute, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Radiology, McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.

Rebecca Charbonneau (R)

Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
RestoreNetwork, Hotchkiss Brain Institute, Libin Cardiovascular Institute, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Ian Rigby (I)

Department of Emergency Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Steven K Boyd (SK)

Department of Radiology, McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.

Philip J Millar (PJ)

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
ORCID: 0000-0002-2177-1061

Eduardo Martin Moraud (EM)

Department of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Marco Capogrosso (M)

Faculty of Biology, University of Fribourg, Fribourg, Switzerland.

Fabien B Wagner (FB)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Institut des Maladies Neurodégénératives, Université de Bordeaux, UMR, 5293, Bordeaux, France.
ORCID: 0000-0002-9582-6109

Quentin Barraud (Q)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Erwan Bezard (E)

Motac Neuroscience Ltd, Manchester, UK.
Institut des Maladies Neurodégénératives, Université de Bordeaux, UMR, 5293, Bordeaux, France.
Institut des Maladies Neurodégénératives, CNRS, UMR, 5293, Bordeaux, France.
ORCID: 0000-0002-0410-4638

Stéphanie P Lacour (SP)

Centre for Neuroprosthetics, Institute of Microengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
ORCID: 0000-0001-9075-4022

Jocelyne Bloch (J)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Department of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Department of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Grégoire Courtine (G)

Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. gregoire.courtine@epfl.ch.
Department of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland. gregoire.courtine@epfl.ch.
Department of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland. gregoire.courtine@epfl.ch.
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland. gregoire.courtine@epfl.ch.
ORCID: 0000-0002-5744-4142

Aaron A Phillips (AA)

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. aaron.phillips@ucalgary.ca.
Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. aaron.phillips@ucalgary.ca.
Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. aaron.phillips@ucalgary.ca.
International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada. aaron.phillips@ucalgary.ca.
RestoreNetwork, Hotchkiss Brain Institute, Libin Cardiovascular Institute, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. aaron.phillips@ucalgary.ca.
ORCID: 0000-0002-7845-1464

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Réflexe › Baroréflexe › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Biotechnologie › Biomimétique › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée LEW › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Plaies et blessures › Traumatismes de la moelle épinière › Neuroprosthetic baroreflex controls...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Système nerveux sympathique › Neuroprosthetic baroreflex controls...