[Bronchial dilatations in patients with chronic obstructive pulmonary disease in a Tunisian center: effect on disease progression and prognosis].
Dilatations des bronches chez les patients porteurs de bronchopneumopathie chronique obstructive au centre Tunisien: impact sur l’évolution et le pronostic.
Aged
Airway Obstruction
/ epidemiology
Bronchiectasis
/ etiology
Dilatation
Disease Progression
Female
Follow-Up Studies
Hospitalization
/ statistics & numerical data
Humans
Male
Middle Aged
Prognosis
Pulmonary Disease, Chronic Obstructive
/ mortality
Respiration, Artificial
/ statistics & numerical data
Retrospective Studies
Severity of Illness Index
Survival
Tunisia
COPD
Chronic obstructive pulmonary
PFT
bronchial dilation
disease exacerbation
hospitalization
pulmonary function tests
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
06
2020
accepted:
12
09
2020
entrez:
28
1
2021
pubmed:
29
1
2021
medline:
3
2
2021
Statut:
epublish
Résumé
bronchial dilations (BDs) seem to have a major role in the natural history of chronic obstructive pulmonary disease (COPD). The purpose of our study was to evaluate the impact of BDs on the severity and progression of COPD as well as on patients' prognosis. we conducted a retrospective, single-center, analytical study over the period 1995- 2017. The study was based on data from the medical records of patients with COPD who had undergone chest CT scan during the follow-up period. We compared two groups (G) of patients: G1: COPD with BDs; G2: COPD without BDs. our study included 466 patients with COPD. Among them 101 (21.6%) had BDs associated with COPD. G1 patients had lower maximum expiratory volume in the first second (FEV1) (G1: 1.21 L, G2: 1.37 L, p = 0.015), lower forced vital capacity (FVC) (p = 0.014), a lower PaO2 at steady state (p = 0.049), a higher rate of acute exacerbations (AE) per year (G1: 3.31, G2: 2.44, p = 0.001) and a higher rate of hospitalizations in the Intensive Care Unit per year (p = 0.02). G1 patients with AE receiving treatment in hospital had lower PaO2 3) on admission (G1: 60 mmHg, G2: 63.7 mmHg, p = 0.02 G2: 63.7 mmHg, p = 0.023), more elevated carbon dioxide (CO2) levels (p = 0.001) and were characterized by a higher use of non-invasive ventilation (NIV) (p = 0.044) and invasive mechanical ventilation (p = 0.011). G2 patients had better overall survival (p = 0.002). bronchial dilatations are an indicator of poor prognosis in patients with chronic obstructive pulmonary disease, expecially because of the higher rate and severity of exacerbations, airway obstructions and mortality.
Identifiants
pubmed: 33505569
doi: 10.11604/pamj.2020.37.200.24448
pii: PAMJ-37-200
pmc: PMC7813652
doi:
Types de publication
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
200Informations de copyright
Copyright: Ahmed Ben Saad et al.
Déclaration de conflit d'intérêts
Les auteurs ne déclarent aucuns conflits d'intérêts
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