Multicentric carpotarsal osteolysis syndrome (MCTO) with generalized high bone turnover and high serum RANKL: Response to denosumab.

ACR, albumin to creatinine ratio Bone turnover CTX, C-telopeptide Denosumab ESKD, end stage kidney disease HRpQCT HRpQCT, high resolution peripheral quantitative computed tomography MCTO MCTO, Multicentric Carpotarsal Osteolysis Syndrome MafB, gene v-maf musculoaponeurotic fibrosarcoma oncogene ortholog B OPG OPG, osteoprotegerin Osteoporosis RANKL RANKL, receptor activator of nuclear factor-кB ligand

Journal

Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 29 09 2020
revised: 03 01 2021
accepted: 06 01 2021
entrez: 28 1 2021
pubmed: 29 1 2021
medline: 29 1 2021
Statut: epublish

Résumé

MCTO is a rare disorder, caused by mutations in the

Identifiants

pubmed: 33506078
doi: 10.1016/j.bonr.2021.100747
pii: S2352-1872(21)00002-4
pmc: PMC7815641
doi:

Types de publication

Case Reports

Langues

eng

Pagination

100747

Informations de copyright

© 2021 The Authors. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

None. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We declare that the manuscript is being submitted only to Bone, that it will not be submitted elsewhere, while under consideration, that it has not been published elsewhere, and, should it be published in Bone, that it will not be published elsewhere—either in similar form or verbatim—without permission of the editors. These restrictions do not apply to abstracts or to press reports of presentations at scientific meetings.

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Auteurs

Ravit Regev (R)

Division of Endocrinology, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
University of Toronto, Toronto, ON, Canada.

Etienne B Sochett (EB)

Division of Endocrinology, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
University of Toronto, Toronto, ON, Canada.

Yesmino Elia (Y)

Division of Endocrinology, The Hospital for Sick Children, Toronto, ON, Canada.

Ronald M Laxer (RM)

Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
University of Toronto, Toronto, ON, Canada.

Damien Noone (D)

Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
University of Toronto, Toronto, ON, Canada.

Kristi Whitney-Mahoney (K)

Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada.

Kornelia Filipowski (K)

Division of Endocrinology, The Hospital for Sick Children, Toronto, ON, Canada.

Amer Shamas (A)

Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
University of Toronto, Toronto, ON, Canada.

Reza Vali (R)

Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
University of Toronto, Toronto, ON, Canada.

Classifications MeSH