Biomimetic Tympanic Membrane Replacement Made by Melt Electrowriting.
MEW
biomimicry
implants
melt electrowriting
tympanic membranes
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
06
01
2021
received:
26
11
2020
pubmed:
29
1
2021
medline:
9
6
2021
entrez:
28
1
2021
Statut:
ppublish
Résumé
The tympanic membrane (TM) transfers sound waves from the air into mechanical motion for the ossicular chain. This requires a high sensitivity to small dynamic pressure changes and resistance to large quasi-static pressure differences. The TM achieves this by providing a layered structure of about 100µm in thickness, a low flexural stiffness, and a high tensile strength. Chronically infected middle ears require reconstruction of a large area of the TM. However, current clinical treatment can cause a reduction in hearing. With the novel additive manufacturing technique of melt electrowriting (MEW), it is for the first time possible to fabricate highly organized and biodegradable membranes within the dimensions of the TM. Scaffold designs of various fiber composition are analyzed mechanically and acoustically. It can be demonstrated that by customizing fiber orientation, fiber diameter, and number of layers the desired properties of the TM can be met. An applied thin collagen layer seals the micropores of the MEW-printed membrane while keeping the favorable mechanical and acoustical characteristics. The determined properties are beneficial for implantation, closely match those of the human TM, and support the growth of a neo-epithelial layer. This proves the possibilities to create a biomimimetic TM replacement using MEW.
Identifiants
pubmed: 33506636
doi: 10.1002/adhm.202002089
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2002089Informations de copyright
© 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
Références
J. Acuin, W. H. O. Dept. of Child and Adolescent Health and the Team for Prevention of Blindness and Deafness, 2004.
M. Verhoeff, E. L. van der Veen, M. M. Rovers, E. A. M. Sanders, A. G. M. Schilder, Int. J. Pediatr. Otorhinolaryngol. 2006, 70, 1.
D. Muerbe, T. Zahnert, M. Bornitz, K.-B. Huettenbrink, Laryngoscope 2002, 112, 1769.
S. Indorewala, Laryngoscope 2002, 112, 727.
S. Khalilullah, S. P. Shah, D. Yadav, R. P. Shrivastav, H. Bhattarai, Head Face Med. 2016, 12, 26.
G. Volandri, F. Di Puccio, P. Forte, C. Carmignani, J. Biomech. 2011, 44, 1219.
L. Feenstra, F. E. Kohn, J. Feyen, Clin. Otolaryngol. 1984, 9, 215.
D. J. Lim, Acta Otolaryngol. 1970, 70, 176.
S. Van der Jeught, J. J. J. Dirckx, J. R. M. Aerts, A. Bradu, A. G. Podoleanu, J. A. N. Buytaert, J. Assoc. Res. Otolaryngol. 2013, 14, 483.
P. Hong, M. Bance, P. F. Gratzer, Int. J. Pediatr. Otorhinolaryngol. 2013, 77, 3.
B. M. Teh, R. J. Marano, Y. Shen, P. L. Friedland, R. J. Dilley, M. D. Atlas, Tissue Eng., Part B 2013, 19, 116.
B. J. Allardyce, R. Rajkhowa, R. J. Dilley, Z. Xie, L. Campbell, A. Keating, M. D. Atlas, M. von Unge, X. Wang, J. Mech. Behave. Biomed. 2016, 64, 65.
K. N. O'Connor, M. Tam, N. H. Blevins, S. Puria, Laryngoscope 2008, 118, 483.
C. Mota, S. Danti, D. D'Alessandro, L. Trombi, C. Ricci, D. Puppi, D. Dinucci, M. Milazzo, C. Stefanini, F. Chiellini, L. Moroni, S. Berrettini, Biofabrication 2015, 7, 025005.
E. D. Kozin, N. L. Black, J. T. Cheng, M. J. Cotler, M. J. McKenna, D. J. Lee, J. A. Lewis, J. J. Rosowski, A. K. Remenschneider, Hear. Res. 2016, 340, 191.
C.-Y. Kuo, E. Wilson, A. Fuson, N. Gandhi, R. Monfaredi, A. Jenkins, M. Romero, M. Santoro, J. P. Fisher, K. Cleary, B. Reilly, Tissue Eng., Part A 2018, 24, 527.
T. D. Brown, P. D. Dalton, D. W. Hutmacher, Adv. Mater. 2011, 23, 5651.
Á. G. Marín, D. Lohse, Phys. Fluids 2010, 22, 122104.
P. D. Dalton, Curr. Opin. Biomed. Eng. 2017, 2, 49.
J. Winder, R. Bibb, J. Oral Maxillofac. Surg. 2005, 63, 1006.
G. Hochleitner, T. Jüngst, T. D. Brown, K. Hahn, C. Moseke, F. Jakob, P. D. Dalton, J. Groll, Biofabrication 2015, 7, 035002.
J. Chen, S. Han, M. Huang, J. Li, M. Zhou, J. He, Int. J. Polym. Mater. 2020, 1.
S. Moscato, A. Rocca, D. D'Alessandro, D. Puppi, V. Gramigna, M. Milazzo, C. Stefanini, F. Chiellini, M. Petrini, S. Berrettini, S. Danti, Appl. Sci. 2020, 10, 3043.
S. Florczak, T. Lorson, T. Zheng, M. Mrlik, D. W. Hutmacher, M. J. Higgins, R. Luxenhofer, Polym. Int. 2018, 84, 31.
F. Chen, G. Hochleitner, T. Woodfield, J. Groll, P. D. Dalton, B. G. Amsden, Biomacromolecules 2016, 17, 208.
A. Fuchs, A. Youssef, A. Seher, G. Hochleitner, P. D. Dalton, S. Hartmann, R. C. Brands, U. D. A. Müller-Richter, C. Linz, BMC Oral Health 2019, 19, 28.
K. F. Eichholz, D. A. Hoey, Acta Biomater. 2018, 75, 140.
C. B. Dayan, F. Afghah, B. S. Okan, M. Yıldız, Y. Menceloglu, M. Culha, B. Koc, Mater. Des. 2018, 148, 87.
M. L. Muerza-Cascante, D. Haylock, D. W. Hutmacher, P. D. Dalton, Tissue Eng., Part 2015, 21, 187.
N. T. Saidy, F. Wolf, O. Bas, H. Keijdener, D. W. Hutmacher, P. Mela, E. M. De-Juan-Pardo, Small 2019, 15, 1900873.
Y. Jin, Q. Gao, C. Xie, G. Li, J. Du, J. Fu, Y. He, Mater. Des. 2020, 185, 108274.
M. A. Woodruff, D. W. Hutmacher, Prog. Polym. Sci. 2010, 35, 1217.
T. D. Brown, P. D. Dalton, D. W. Hutmacher, Prog. Polym. Sci. 2016, 56, 116.
J. Aernouts, J. J. J. Dirckx, Biomech. Model Mechan. 2012, 11, 829.
J. Aernouts, J. A. M. Soons, J. J. J. Dirckx, Hear. Res. 2010, 263, 177.
J. R. Taylor, Classical Mechanics, University Science Books, Sausalito, CA 2005.1.580
J. J. Rosowski, H. H. Nakajima, S. N. Merchant, Ear Hear 2007, 29, 3.
D. De Greef, J. Aernouts, J. Aerts, J. T. Cheng, R. Horwitz, J. J. Rosowski, J. J. J. Dirckx, Hear. Res. 2014, 312, 69.
T. Zahnert, K. Huttenbrink, D. Murbe, M. Bornitz, Am. J. Otolaryngol. 2000, 21, 322.
W. F. Decraemer, W. R. J. Funnell, in Chronic Otitis Media. Pathogenesis-Oriented Therapeutic Management, Kugler Publications, Amsterdam 2008, Anatomical and mechanical properties of the tympanic membrane pp. 51-84. http://audilab.bme.mcgill.ca/~funnell/AudiLab/decraemer_funnell_2008.pdf.
H. Luo, C. Dai, R. Z. Gan, H. Lu, J. Biomech. Eng. 2009, 131, 1.
N. P. Daphalapurkar, C. Dai, R. Z. Gan, H. Lu, J. Mech. Behave. Biomed. 2009, 2, 82.
J. E. Benecke, Laryngoscope 2001, 111, 1525.
J. Knutsson, D. Bagger-Sjöbäck, M. von Unge, Otol. Neurotol. 2009, 30, 1225.
K. Stenfeldt, C. Johansson, S. Hellström, Arch. Otolaryngol. Head Neck Surg. 2006, 132, 293.
L. A. Bosworth, A. Gibb, S. Downes, J. Polym. Sci. B Polym. Phys. 870, 2012, 50, 870.
K. A. Faraj, K. M. Brouwer, P. J. Geutjes, E. M. Versteeg, R. G. Wismans, J. A. Deprest, H. Chajra, D. M. Tiemessen, W. F. J. Feitz, E. Oosterwijk, W. F. Daamen, T. H. van Kuppevelt, J. Tissue Eng. Regener. Med. 2011, 8, 460.
K. Gorna, S. Gogolewski, Polym. Degrad. Stabil. 2003, 79, 465.
M. Achilli, J. Lagueux, D. Mantovani, Macromol. Biosci. 2010, 10, 307.
J. P. Widdowson, N. Hilal, C. J. Wright, N. Hilal, C. J. Wright, in Nanofiber Membranes for Medical, Environmental, and Energy Applications, CRC Press, Boca Raton, 2019, p. 57.
K. S. Weadock, E. J. Miller, L. D. Bellincampi, J. P. Zawadsky, M. G. Dunn, J. Biomed. Mater. Res. 1995, 29, 1373.
A. Youssef, A. Hrynevich, L. Fladeland, A. Balles, J. Groll, P. D. Dalton, S. Zabler, Tissue Eng., Part C 2019, 25, 367.
O. Bas, E. M. De-Juan-Pardo, M. P. Chhaya, F. M. Wunner, J. E. Jeon, T. J. Klein, D. W. Hutmacher, Eur. Polym. 2015, 72, 451.
J. Visser, F. P. W. Melchels, J. E. Jeon, E. M. van Bussel, L. S. Kimpton, H. M. Byrne, W. J. A. Dhert, P. D. Dalton, D. W. Hutmacher, J. Malda, Nat. Commun. 2015, 6, 6933.
M. Castilho, G. Hochleitner, W. Wilson, B. van Rietbergen, P. D. Dalton, J. Groll, J. Malda, K. Ito, Sci. Rep. 2018, 8, 1245.
M. Castilho, V. Mouser, M. Chen, J. Malda, K. Ito, Acta Biomater. 2019, 95, 297.
I. Arechvo, M. Bornitz, N. Lasurashvili, T. Zahnert, T. Beleites, Otol. Neurotol. 2012, 33, 60.
H. Yamada, R. L. Goode, Otol. Neurotol. 2010, 31, 1404.
C. Xie, Q. Gao, P. Wang, L. Shao, H. Yuan, J. Fu, W. Chen, Y. He, Mater. Des. 2019, 181, 108092.
T. Jungst, I. Pennings, M. Schmitz, A. J. W. P. Rosenberg, J. Groll, D. Gawlitta, Adv. Funct. Mater. 2019, 29, 1905987.
S. H. Park, D. S. Park, J. W. Shin, Y. G. Kang, H. K. Kim, T. R. Yoon, J.-W. Shin, J. Mater. Sci. Mater. Med. 2012, 23, 2671.
H. Seyednejad, D. Gawlitta, R. V. Kuiper, A. de Bruin, C. F. van Nostrum, T. Vermonden, W. J. A. Dhert, W. E. Hennink, Biomaterials 2012, 33, 4309.