Association Between Greater Cerebellar Network Connectivity and Improved Phonemic Fluency Performance After Exercise Training in Older Adults.
Aging
Cerebellum
Exercise training
Functional connectivity
MCI
Phonemic fluency
Journal
Cerebellum (London, England)
ISSN: 1473-4230
Titre abrégé: Cerebellum
Pays: United States
ID NLM: 101089443
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
accepted:
10
11
2020
pubmed:
29
1
2021
medline:
7
4
2022
entrez:
28
1
2021
Statut:
ppublish
Résumé
Little is known about the effects of exercise training (ET) on lexical characteristics during fluency task and its association with cerebellum functional connectivity. The purposes of this study were (1) to investigate whether ET alters response patterns during phonemic and semantic fluency tasks and (2) to assess the association between ET-related changes in cerebellum functional connectivity (FC) and lexical characteristics during fluency tasks. Thirty-five older adults (78.0 ± 7.1 years; 17 mild cognitive impairment (MCI) and 18 healthy cognition (HC)) underwent a 12-week treadmill ET. Before and after ET, cardiorespiratory fitness tests, phonemic and semantic fluency tests, and resting-state fMRI scans were administered. We utilized a seed-based correlation analysis to measure cerebellum FC and linear regression to assess the association of residualized ET-induced Δcerebellum FC with Δtask performance. Improved mean switches and frequency during the phonemic fluency task were observed following ET in all participants. There were significant associations between ET-induced increases in cerebellum FC and greater phonemic fluency task log frequency, increases in mean switches, and a reduction in the number of syllables in HC. Lastly, there was a significant interaction between group and cerebellar connectivity on phonemic fluency mean log frequency and number of syllables. A 12-week walking ET is related to enhanced phonemic fluency lexical characteristics in older adults with MCI and HC. The association between ET-induced increases in cerebellum FC and enhanced response patterns after ET suggests that the cerebellum may play an important role in ET-related improvement in phonemic fluency performance in cognitively healthy older adults.
Identifiants
pubmed: 33507462
doi: 10.1007/s12311-020-01218-3
pii: 10.1007/s12311-020-01218-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
542-555Subventions
Organisme : NIH HHS
ID : 8UL1TR000055
Pays : United States
Organisme : NIH HHS
ID : 8KL2TR000056
Pays : United States
Organisme : NIH HHS
ID : 8UL1TR000055
Pays : United States
Organisme : NIH HHS
ID : 8KL2TR000056
Pays : United States
Informations de copyright
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.
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