The evolution of epigenetic therapy in myelodysplastic syndromes and acute myeloid leukemia.

Epigenesis, Genetic Epigenomics Humans Leukemia, Myeloid, Acute / drug therapy Mutation Myelodysplastic Syndromes / drug therapy

Journal

Seminars in hematology
ISSN: 1532-8686
Titre abrégé: Semin Hematol
Pays: United States
ID NLM: 0404514

Informations de publication

Date de publication:
01 2021
Historique:
received: 12 10 2020
revised: 11 12 2020
accepted: 19 12 2020
entrez: 29 1 2021
pubmed: 30 1 2021
medline: 6 4 2022
Statut: ppublish

Résumé

Mutations in the group of epigenetic modifiers are the largest group of mutated genes in Myelodysplastic Syndromes (MDS) and are very frequently found in Acute Myeloid Leukemia (AML). Our advancements in the understanding of epigenetics in these diseases have helped develop groundbreaking therapeutics that have changed the treatment landscape of MDS and AML, significantly improving outcomes. In this review we describe the most common epigenetic aberrations in MDS and AML, and current treatments that target mutations in epigenetic modifiers, as well as novel treatment combinations, from standard therapies to investigational treatments.

Identifiants

DOI: 10.1053/j.seminhematol.2020.12.003 PMID: 33509444
pubmed: 33509444
pii: S0037-1963(20)30076-7
doi: 10.1053/j.seminhematol.2020.12.003
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

56-65

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Jesus D Gonzalez-Lugo (JD)

Division of Hematologic Malignancies, Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY.

Samarpana Chakraborty (S)

Division of Hematologic Malignancies, Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY; Department of Molecular & Developmental Biology, Albert Einstein College of Medicine, Bronx, NY.

Amit Verma (A)

Division of Hematologic Malignancies, Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY; Department of Molecular & Developmental Biology, Albert Einstein College of Medicine, Bronx, NY.

Aditi Shastri (A)

Division of Hematologic Malignancies, Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY; Department of Molecular & Developmental Biology, Albert Einstein College of Medicine, Bronx, NY. Electronic address: ashastri@montefiore.org.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › The evolution of epigenetic therapy in...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › The evolution of epigenetic therapy in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The evolution of epigenetic therapy in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › The evolution of epigenetic therapy in...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The evolution of epigenetic therapy in...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Maladies de la moelle osseuse › Syndromes myélodysplasiques › The evolution of epigenetic therapy in...