Mapping Large-Scale Networks Associated with Action, Behavioral Inhibition and Impulsivity.
behavioral inhibition
brain mapping
impulsivity
local field potentials
orbitofrontal cortex
oscillations
Journal
eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362
Informations de publication
Date de publication:
Historique:
received:
20
09
2020
revised:
06
01
2021
accepted:
08
01
2021
pubmed:
30
1
2021
medline:
22
6
2021
entrez:
29
1
2021
Statut:
epublish
Résumé
A key aspect of behavioral inhibition is the ability to wait before acting. Failures in this form of inhibition result in impulsivity and are commonly observed in various neuropsychiatric disorders. Prior evidence has implicated medial frontal cortex, motor cortex, orbitofrontal cortex (OFC), and ventral striatum in various aspects of inhibition. Here, using distributed recordings of brain activity [with local-field potentials (LFPs)] in rodents, we identified oscillatory patterns of activity linked with action and inhibition. Low-frequency (δ) activity within motor and premotor circuits was observed in two distinct networks, the first involved in cued, sensory-based responses and the second more generally in both cued and delayed actions. By contrast, θ activity within prefrontal and premotor regions (medial frontal cortex, OFC, ventral striatum, and premotor cortex) was linked with inhibition. Connectivity at θ frequencies was observed within this network of brain regions. Interestingly, greater connectivity between primary motor cortex (M1) and other motor regions was linked with greater impulsivity, whereas greater connectivity between M1 and inhibitory brain regions (OFC, ventral striatum) was linked with improved inhibition and diminished impulsivity. We observed similar patterns of activity on a parallel task in humans: low-frequency activity in sensorimotor cortex linked with action, θ activity in OFC/ventral prefrontal cortex (PFC) linked with inhibition. Thus, we show that δ and θ oscillations form distinct large-scale networks associated with action and inhibition, respectively.
Identifiants
pubmed: 33509949
pii: ENEURO.0406-20.2021
doi: 10.1523/ENEURO.0406-20.2021
pmc: PMC7920541
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : BLRD VA
ID : IK2 BX003308
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH123650
Pays : United States
Organisme : NIMH NIH HHS
ID : R25 MH081482
Pays : United States
Informations de copyright
Copyright © 2021 Fakhraei et al.
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