Phospholipase A2 receptor 1 promotes lung cell senescence and emphysema in obstructive lung disease.
Journal
The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
18
03
2020
accepted:
28
12
2020
pubmed:
30
1
2021
medline:
7
9
2021
entrez:
29
1
2021
Statut:
epublish
Résumé
Cell senescence is a key process in age-associated dysfunction and diseases, notably chronic obstructive pulmonary disease (COPD). We previously identified phospholipase A2 receptor 1 (PLA2R1) as a positive regulator of cell senescence acting We assessed cell senescence in lungs and cultured lung cells from patients with COPD and controls subjected to We found that Our data support a major role for PLA2R1 activation in driving lung cell senescence and lung alterations in COPD. Targeting JAK1/2 may represent a promising therapeutic approach for COPD.
Sections du résumé
BACKGROUND
Cell senescence is a key process in age-associated dysfunction and diseases, notably chronic obstructive pulmonary disease (COPD). We previously identified phospholipase A2 receptor 1 (PLA2R1) as a positive regulator of cell senescence acting
METHODS
We assessed cell senescence in lungs and cultured lung cells from patients with COPD and controls subjected to
RESULTS
We found that
CONCLUSIONS
Our data support a major role for PLA2R1 activation in driving lung cell senescence and lung alterations in COPD. Targeting JAK1/2 may represent a promising therapeutic approach for COPD.
Identifiants
pubmed: 33509955
pii: 13993003.00752-2020
doi: 10.1183/13993003.00752-2020
pii:
doi:
Substances chimiques
PLA2R1 protein, human
0
Receptors, Phospholipase A2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright ©The authors 2021. For reproduction rights and permissions contact permissions@ersnet.org.
Déclaration de conflit d'intérêts
Conflict of interest: D. Beaulieu has nothing to disclose. Conflict of interest: A. Attwe has nothing to disclose. Conflict of interest: M. Breau has nothing to disclose. Conflict of interest: L. Lipskaia has nothing to disclose. Conflict of interest: E. Marcos has nothing to disclose. Conflict of interest: E. Born has nothing to disclose. Conflict of interest: J. Huang has nothing to disclose. Conflict of interest: S. Abid has nothing to disclose. Conflict of interest: G. Derumeaux has nothing to disclose. Conflict of interest: A. Houssaini has nothing to disclose. Conflict of interest: B. Maitre has nothing to disclose. Conflict of interest: M. Lefevre has nothing to disclose. Conflict of interest: N. Vienney has nothing to disclose. Conflict of interest: P. Bertolino has nothing to disclose. Conflict of interest: S. Jaber has nothing to disclose. Conflict of interest: H. Noureddine has nothing to disclose. Conflict of interest: D. Goehrig has nothing to disclose. Conflict of interest: D. Vindrieux has nothing to disclose. Conflict of interest: D. Bernard has nothing to disclose. Conflict of interest: S. Adnot has nothing to disclose.