Lower values of a novel index of Vagal-Neuroimmunomodulation are associated to higher all-cause mortality in two large general population samples with 18 year follow up.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 01 2021
28 01 2021
Historique:
received:
27
07
2020
accepted:
15
01
2021
entrez:
29
1
2021
pubmed:
30
1
2021
medline:
2
10
2021
Statut:
epublish
Résumé
In recent clinical practice, a biomarker of vagal neuroimmunomodulation (NIM), namely the ratio of vagally-mediated heart rate variability (vmHRV) and CRP, was proposed to index the functionality of the cholinergic anti-inflammatory pathway. This study aims to transfer and extend the previous findings to two general population-based samples to explore the hypothesis that NIM-ratio is associated with all-cause mortality. Two large population studies (MIDUS 2: N = 1255 and Whitehall II wave 5: N = 7870) with complete data from a total of N = 3860 participants (36.1% females; average age = 56.3 years; 11.1% deaths, last exit 18.1 years post inclusion) were available. NIM indices were calculated using the vagally-mediated HRV measure RMSSD divided by measures of CRP (NIM
Identifiants
pubmed: 33510335
doi: 10.1038/s41598-021-82168-6
pii: 10.1038/s41598-021-82168-6
pmc: PMC7844270
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2554Subventions
Organisme : Medical Research Council
ID : MR/R024227/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U19 AG051426
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001409
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL036310
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG013196
Pays : United States
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