Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities.
Alzheimer Disease
/ epidemiology
Animals
Bone Marrow
/ immunology
Causality
Colorectal Neoplasms
/ epidemiology
Comorbidity
Gastrointestinal Microbiome
/ immunology
Humans
Inflammation
/ epidemiology
Inflammatory Bowel Diseases
/ epidemiology
Models, Biological
Mouth
/ microbiology
Periodontal Diseases
/ epidemiology
Periodontitis
/ epidemiology
Risk Factors
Journal
Nature reviews. Immunology
ISSN: 1474-1741
Titre abrégé: Nat Rev Immunol
Pays: England
ID NLM: 101124169
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
accepted:
09
12
2020
pubmed:
30
1
2021
medline:
27
8
2021
entrez:
29
1
2021
Statut:
ppublish
Résumé
Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically associated with other chronic inflammation-driven disorders, including cardio-metabolic, neurodegenerative and autoimmune diseases and cancer. Emerging evidence from interventional studies indicates that local treatment of periodontitis ameliorates surrogate markers of comorbid conditions. The potential causal link between periodontitis and its comorbidities is further strengthened by recent experimental animal studies establishing biologically plausible and clinically consistent mechanisms whereby periodontitis could initiate or aggravate a comorbid condition. This multi-faceted 'mechanistic causality' aspect of the link between periodontitis and comorbidities is the focus of this Review. Understanding how certain extra-oral pathologies are affected by disseminated periodontal pathogens and periodontitis-associated systemic inflammation, including adaptation of bone marrow haematopoietic progenitors, may provide new therapeutic options to reduce the risk of periodontitis-associated comorbidities.
Identifiants
pubmed: 33510490
doi: 10.1038/s41577-020-00488-6
pii: 10.1038/s41577-020-00488-6
pmc: PMC7841384
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
426-440Subventions
Organisme : NIDCR NIH HHS
ID : R37 DE026152
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE029436
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028561
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE024716
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE024153
Pays : United States
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