Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways.
A. fumigatus
Antifungal core host response
C. albicans
Cytokines
Host immune response
Immunometabolism
Opportunistic infections
Pattern recognition receptors
R. oryzae
RNAseq
Transcriptomics of pathogenic fungi
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
10
2020
revised:
22
12
2020
accepted:
23
12
2020
entrez:
29
1
2021
pubmed:
30
1
2021
medline:
30
1
2021
Statut:
epublish
Résumé
Candidiasis, aspergillosis, and mucormycosis cause the majority of nosocomial fungal infections in immunocompromised patients. Using an unbiased transcriptional profiling in PBMCs exposed to the fungal species causing these infections, we found a core host response in healthy individuals that may govern effective fungal clearance: it consists of 156 transcripts, involving canonical and non-canonical immune pathways. Systematic investigation of key steps in antifungal host defense revealed fungal-specific signatures. As previously demonstrated,
Identifiants
pubmed: 33510868
doi: 10.1016/j.csbj.2020.12.036
pii: S2001-0370(20)30561-4
pmc: PMC7817431
doi:
Types de publication
Journal Article
Langues
eng
Pagination
647-663Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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