Designed U7 snRNAs inhibit

DUX4 FSHD RNA silencing U7 gene therapy snRNA

Journal

Molecular therapy. Nucleic acids
ISSN: 2162-2531
Titre abrégé: Mol Ther Nucleic Acids
Pays: United States
ID NLM: 101581621

Informations de publication

Date de publication:
05 Mar 2021
Historique:
received: 11 08 2020
accepted: 06 12 2020
entrez: 29 1 2021
pubmed: 30 1 2021
medline: 30 1 2021
Statut: epublish

Résumé

Facioscapulohumeral muscular dystrophy (FSHD) arises from epigenetic changes that de-repress the

Identifiants

pubmed: 33510937
doi: 10.1016/j.omtn.2020.12.004
pii: S2162-2531(20)30385-1
pmc: PMC7807095
doi:

Types de publication

Journal Article

Langues

eng

Pagination

476-486

Subventions

Organisme : NIAMS NIH HHS
ID : P50 AR070604
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD060848
Pays : United States

Informations de copyright

© 2020 The Author(s).

Déclaration de conflit d'intérêts

The sequences and methods described here were included in a provisional patent application filed on December 1, 2020 (USPTO serial no. 63/120,190). S.Q.H., A.R., and N.W. are listed as inventors.

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Auteurs

Afrooz Rashnonejad (A)

Center for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

Gholamhossein Amini-Chermahini (G)

Center for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

Noah K Taylor (NK)

Center for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

Nicolas Wein (N)

Center for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Department of Pediatrics, The Ohio State University, Columbus, OH, USA.

Scott Q Harper (SQ)

Center for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Department of Pediatrics, The Ohio State University, Columbus, OH, USA.

Classifications MeSH