Stem Cell Therapy Potency in Personalizing Severe COVID-19 Treatment.
COVID-19
Cell-based therapy
Personalized medicine
Stem cell
Journal
Stem cell reviews and reports
ISSN: 2629-3277
Titre abrégé: Stem Cell Rev Rep
Pays: United States
ID NLM: 101752767
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
accepted:
16
12
2020
pubmed:
30
1
2021
medline:
3
3
2021
entrez:
29
1
2021
Statut:
ppublish
Résumé
Currently, there are no specific and efficient vaccines or drugs for COVID-19, particularly in severe cases. A wide range of variations in the clinical symptoms of different patients attributed to genomic differences. Therefore, personalized treatments seem to play a critical role in improving these symptoms and even similar conditions. Prompted by the uncertainties in the area of COVID-19 therapies, we reviewed the published papers and concepts to gather and provide useful information to clinicians and researchers interested in personalized medicine and cell-based therapy. One novel aspect of this study focuses on the potential application of personalized medicine in treating severe cases of COVID-19. However, it is theoretical, as any real-world examples of the use of genuinely personalized medicine have not existed yet. Nevertheless, we know that stem cells, especially MSCs, have immune-modulatory effects and can be stored for future personalized medicine applications. This theory has been conjugated with some evidence that we review in the present study. Besides, we discuss the importance of personalized medicine and its possible aspects in COVID-19 treatment, then review the cell-based therapy studies for COVID-19 with a particular focus on stem cell-based therapies as a primary personalized tool medicine. However, the idea of cell-based therapy has not been accepted by several scientific communities due to some concerns of lack of satisfactory clinical studies; still, the MSCs and their clinical outcomes have been revealed the safety and potency of this therapeutic approach in several diseases, especially in the immune-mediated inflammatory diseases and some incurable diseases. Promising outcomes have resulted in that clinical studies are going to continue.
Identifiants
pubmed: 33511518
doi: 10.1007/s12015-020-10110-w
pii: 10.1007/s12015-020-10110-w
pmc: PMC7842180
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-213Références
Cytotherapy. 2021 Jun;23(6):471-482
pubmed: 33257213
Pain Physician. 2020 Mar;23(2):E71-E83
pubmed: 32214286
Vaccines (Basel). 2019 Apr 24;7(2):
pubmed: 31022829
APMIS. 2018 Mar;126(3):227-233
pubmed: 29372577
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Cell Stem Cell. 2008 Feb 7;2(2):141-50
pubmed: 18371435
Engineering (Beijing). 2020 Oct;6(10):1153-1161
pubmed: 32292627
Stem Cells Transl Med. 2019 Mar;8(3):271-284
pubmed: 30394698
BMC Immunol. 2014 Oct 03;15:41
pubmed: 25277705
Vet Microbiol. 2019 Mar;230:178-186
pubmed: 30827386
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
Hum Cell. 2020 Oct;33(4):907-918
pubmed: 32780299
Biomark Res. 2019 Apr 4;7:8
pubmed: 30992990
Stem Cell Res Ther. 2018 Jan 29;9(1):17
pubmed: 29378639
Br J Haematol. 2020 Jul;190(2):e93-e94
pubmed: 32453863
Reprod Sci. 2016 Sep;23(9):1193-207
pubmed: 26902429
N Engl J Med. 2020 Oct 15;383(16):1522-1534
pubmed: 32558485
Stem Cells Int. 2019 Apr 9;2019:9628536
pubmed: 31093291
Biomed Pharmacother. 2020 Nov;131:110738
pubmed: 33152914
Signal Transduct Target Ther. 2020 Aug 27;5(1):172
pubmed: 32855385
Prog Cardiovasc Dis. 2020 May - Jun;63(3):390-391
pubmed: 32169400
Stem Cell Rev Rep. 2011 Jun;7(2):269-91
pubmed: 20853072
Infect Dis Model. 2020 Feb 11;5:248-255
pubmed: 32099934
Cell Death Differ. 2014 Mar;21(3):388-96
pubmed: 24162664
Stem Cells Transl Med. 2015 Nov;4(11):1302-16
pubmed: 26378259
Stem Cell Res Ther. 2020 Sep 18;11(1):404
pubmed: 32948252
Mil Med Res. 2020 Mar 13;7(1):11
pubmed: 32169119
Blood. 2013 Apr 4;121(14):e98-107
pubmed: 23386128
Indian J Clin Biochem. 2020 Oct;35(4):397-409
pubmed: 32837030
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Int J Mol Sci. 2020 Mar 27;21(7):
pubmed: 32230828
Cell Discov. 2020 Feb 24;6:11
pubmed: 32133153
Cell Host Microbe. 2016 Sep 14;20(3):392-405
pubmed: 27631702
Stem Cell Rev Rep. 2019 Apr;15(2):166-175
pubmed: 30623359
Viruses. 2015 Jul 13;7(7):3835-56
pubmed: 26184286
Science. 1998 Nov 6;282(5391):1145-7
pubmed: 9804556
Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L975-85
pubmed: 24682451
Acta Biomed. 2020 Sep 07;91(3):e2020018
pubmed: 32921715
Biomedicines. 2014 Feb 26;2(1):50-79
pubmed: 28548060
Int J Cell Biol. 2016;2016:6940283
pubmed: 27516776
Nat Neurosci. 2012 Jun;15(6):862-70
pubmed: 22610068
Liver Int. 2020 May;40(5):998-1004
pubmed: 32170806
Gend Med. 2012 Feb;9(1):21-32
pubmed: 22266307
Br J Haematol. 2020 May;189(3):428-437
pubmed: 32297671
Cells. 2020 Apr 09;9(4):
pubmed: 32283815
J Assist Reprod Genet. 2011 Aug;28(8):669-76
pubmed: 21617932
Nature. 2003 Nov 27;426(6965):450-4
pubmed: 14647384
J Immunother Cancer. 2018 Jun 15;6(1):56
pubmed: 29907163
Cell Biol Int. 2012 Aug 1;36(8):747-53
pubmed: 22352320
Eur J Cell Biol. 2019 Jun;98(2-4):81-93
pubmed: 30583806
Adv Exp Med Biol. 2020;1247:89-100
pubmed: 31974923
Cell Discov. 2020 Nov 10;6(1):83
pubmed: 33298875
Nat Rev Endocrinol. 2021 Jan;17(1):11-30
pubmed: 33188364
Medicine (Baltimore). 2020 Jul 31;99(31):e21429
pubmed: 32756149
Stem Cells Dev. 2020 Jun 15;29(12):747-754
pubmed: 32380908
Nat Immunol. 2014 Nov;15(11):1009-16
pubmed: 25329189
J Clin Invest. 1959 Oct;38:1709-16
pubmed: 13837954
Stem Cell Rev Rep. 2021 Feb;17(1):71-93
pubmed: 32895900
Cell Commun Signal. 2011 May 14;9:12
pubmed: 21569606
N Engl J Med. 2020 Nov 5;383(19):1827-1837
pubmed: 32459919
Int J Environ Res Public Health. 2020 May 14;17(10):
pubmed: 32423095
Lancet Infect Dis. 2020 Jun;20(6):669-677
pubmed: 32240634
Cell. 2012 May 25;149(5):1174-1174.e1
pubmed: 22632979
Tissue Eng Part A. 2010 Apr;16(4):1421-31
pubmed: 19951089
Stem Cells. 2010 Dec;28(12):2229-38
pubmed: 20945332
Lancet Infect Dis. 2020 Oct;20(10):1135-1140
pubmed: 32526193
J Cell Biochem. 2018 Jul;119(7):5043-5052
pubmed: 29377240
Front Med. 2020 Oct;14(5):664-673
pubmed: 32761491
Int J Surg. 2020 Apr;76:71-76
pubmed: 32112977
Adv Exp Med Biol. 2018;1119:103-118
pubmed: 30155859
EPMA J. 2020 May 14;11(2):139-145
pubmed: 32419876
World J Stem Cells. 2014 Sep 26;6(4):404-20
pubmed: 25258662
Cytotherapy. 2020 Sep;22(9):474-481
pubmed: 32565132
Asian Pac J Cancer Prev. 2020 Apr 01;21(4):975-982
pubmed: 32334458
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Aging Dis. 2020 Mar 9;11(2):216-228
pubmed: 32257537
N Engl J Med. 2020 Mar 26;382(13):1268-1269
pubmed: 32109011
Stem Cells Int. 2018 Jun 14;2018:3057624
pubmed: 30013600
Stem Cells Transl Med. 2020 Jan;9(1):28-38
pubmed: 31647191
Pediatr Res. 2012 Apr;71(4 Pt 2):452-8
pubmed: 22430381
ACS Pharmacol Transl Sci. 2020 Aug 27;3(5):790-800
pubmed: 33062949
Stem Cells Dev. 2012 Sep 20;21(14):2724-52
pubmed: 22468918
Nanobiomedicine (Rij). 2015 Jan 1;2:5
pubmed: 29942371
Blood. 2006 Jan 1;107(1):367-72
pubmed: 16141348
Stem Cell Rev Rep. 2021 Feb;17(1):56-62
pubmed: 33009982
Curr Stem Cell Res Ther. 2019;14(1):22-33
pubmed: 30210006
Precis Clin Med. 2020 Feb 04;3(1):14-21
pubmed: 32330209
Blood. 2005 Feb 15;105(4):1815-22
pubmed: 15494428
Eur J Haematol. 2020 Nov;105(5):519-523
pubmed: 32589774
Eur Respir J. 2020 Jun 4;55(6):
pubmed: 32265310
PLoS Med. 2016 Mar 24;13(3):e1001977
pubmed: 27011229
Stem Cells Dev. 2020 Jun 1;29(11):679-681
pubmed: 32292113
Methods Mol Biol. 2013;997:23-33
pubmed: 23546745
N Engl J Med. 2020 Feb 20;382(8):692-694
pubmed: 31978293
Sci Rep. 2018 Sep 6;8(1):13351
pubmed: 30190508
Front Immunol. 2020 Jun 23;11:1512
pubmed: 32655581
Curr Opin Virol. 2011 Dec;1(6):497-512
pubmed: 22180766
JAMA. 2015 Apr 28;313(16):1613-4
pubmed: 25919522
Stem Cells Transl Med. 2016 Sep;5(9):1190-203
pubmed: 27496568
J Am Coll Cardiol. 2016 May 10;67(18):2161-2176
pubmed: 27151349
Diabetes Metab Syndr. 2020 Jul - Aug;14(4):655-659
pubmed: 32438328
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
J Cell Mol Med. 2012 Oct;16(10):2518-29
pubmed: 22435530
Med Drug Discov. 2020 Mar;5:100019
pubmed: 32296777
J Biomed Sci. 2019 Oct 28;26(1):87
pubmed: 31660969
Stem Cell Res Ther. 2020 Aug 18;11(1):361
pubmed: 32811531
Stem Cells Int. 2017;2017:8286248
pubmed: 29387091
Nat Rev Drug Discov. 2020 Jul;19(7):463-479
pubmed: 32612263
Bone Marrow Transplant. 2001 Feb;27(3):249-59
pubmed: 11277172
Trends Immunol. 2016 Dec;37(12):877-888
pubmed: 27773685
Adv Exp Med Biol. 2021;1312:19-37
pubmed: 33159303
Stem Cell Rev Rep. 2020 Jun;16(3):427-433
pubmed: 32281052
Differentiation. 2019 Jan - Feb;105:45-53
pubmed: 30711828
Lancet Infect Dis. 2020 Sep;20(9):e238-e244
pubmed: 32628905
Cell Death Dis. 2020 Jul 8;11(7):512
pubmed: 32641681
Nat Med. 2012 Apr 15;18(5):759-65
pubmed: 22504485
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Trends Mol Med. 2012 Feb;18(2):128-34
pubmed: 22118960
J Cell Biochem. 2017 Oct;118(10):3034-3042
pubmed: 28316107
J Public Health (Oxf). 2020 Aug 18;42(3):451-460
pubmed: 32556213
Tob Induc Dis. 2020 Mar 20;18:20
pubmed: 32206052
PLoS One. 2011;6(9):e25171
pubmed: 21980392
Basic Res Cardiol. 2020 May 12;115(4):36
pubmed: 32399655
Aging Dis. 2020 Mar 9;11(2):462-464
pubmed: 32257554
Biores Open Access. 2019 Nov 11;8(1):185-199
pubmed: 31720090
Science. 2007 Dec 21;318(5858):1917-20
pubmed: 18029452
Stem Cell Rev Rep. 2021 Feb;17(1):163-175
pubmed: 32564256
J Reprod Immunol. 2020 Jun;139:103122
pubmed: 32244166
EClinicalMedicine. 2020 Aug;25:100454
pubmed: 32838232