Clioquinol inhibits cell growth in a SERCA2-dependent manner.

Animals Calcium / metabolism Calcium Signaling / drug effects Clioquinol / pharmacology Humans PC12 Cells Rats S Phase Cell Cycle Checkpoints / drug effects Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism
SERCA2 [Ca2+]i clioquinol cytotoxicity sensitivity

Journal

Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231

Informations de publication

Date de publication:
May 2021
Historique:
revised: 06 01 2021
received: 08 09 2020
accepted: 19 01 2021
pubmed: 30 1 2021
medline: 29 7 2021
entrez: 29 1 2021
Statut: ppublish

Résumé

Clioquinol has been reported to act as a potential therapy for neurodegenerative diseases and cancer. However, the underlying mechanism is unclear. We have previously reported that clioquinol induces S-phase cell cycle arrest through the elevation of calcium levels in human neurotypic SH-SY5Y cells. In this study, different types of cells were observed to detect if the effect of clioquinol on intracellular calcium levels is cell type-specific. The Cell Counting Kit-8 assay showed that clioquinol exhibited varying degrees of concentration-dependent cytotoxicity in different cell lines, and that the growth inhibition caused by it was not related to cell source or carcinogenesis. In addition, the inhibition of cell growth by clioquinol was positively associated with its effect on intracellular calcium content ([Ca

Identifiants

DOI: 10.1002/jbt.22727 PMID: 33511738
pubmed: 33511738
doi: 10.1002/jbt.22727
doi:

Substances chimiques

Atp2a2 protein, rat 0
Clioquinol 7BHQ856EJ5
Sarcoplasmic Reticulum Calcium-Transporting ATPases EC 3.6.3.8
ATP2A2 protein, human EC 7.2.2.10
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e22727

Subventions

Organisme : National Natural Science Foundation of China
ID : 31671309
Organisme : the Training Planned Fund of Academic Leaders, Shanghai Pudong New Area Health System
ID : PWR 12018-09

Informations de copyright

© 2021 Wiley Periodicals LLC.

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Auteurs

Xiaoguang Lv (X)

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.

Wei Zhang (W)

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.

Shengli Xia (S)

Department of Orthopedics, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Zhiwei Huang (Z)

Key Lab of Science & Technology of Eco-textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.

Ping Shi (P)

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
ORCID: 0000-0002-6904-2802

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Clioquinol inhibits cell growth in a...
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questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Interphase › Points de contrôle de la phase S du cycle cellulaire › Clioquinol inhibits cell growth in a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › P-type ATPases › Calcium-Transporting ATPases › Sarcoplasmic Reticulum Calcium-Transporting ATPases › Clioquinol inhibits cell growth in a...