High spatial correlation in brain connectivity between micturition and resting states within bladder-related networks using 7 T MRI in multiple sclerosis women with voiding dysfunction.
Brain connectivity
Functional magnetic resonance imaging
Multiple sclerosis
Resting states
Urodynamics
Voiding dysfunction
Journal
World journal of urology
ISSN: 1433-8726
Titre abrégé: World J Urol
Pays: Germany
ID NLM: 8307716
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
10
11
2020
accepted:
08
01
2021
pubmed:
30
1
2021
medline:
29
1
2022
entrez:
29
1
2021
Statut:
ppublish
Résumé
Several studies have reported brain activations and functional connectivity (FC) during micturition using functional magnetic resonance imaging (fMRI) and concurrent urodynamics (UDS) testing. However, due to the invasive nature of UDS procedure, non-invasive resting-state fMRI is being explored as a potential alternative. The purpose of this study is to evaluate the feasibility of utilizing resting states as a non-invasive alternative for investigating the bladder-related networks in the brain. We quantitatively compared FC in brain regions belonging to the bladder-related network during the following states: 'strong desire to void', 'voiding initiation (or attempt at voiding initiation)', and 'voiding (or continued attempt of voiding)' with FC during rest in nine multiple sclerosis women with voiding dysfunction using fMRI data acquired at 7 T and 3 T. The inter-subject correlation analysis showed that voiding (or continued attempt of voiding) is achieved through similar network connections in all subjects. The task-based bladder-related network closely resembles the resting-state intrinsic network only during voiding (or continued attempt of voiding) process but not at other states. Resting states fMRI can be potentially utilized to accurately reflect the voiding (or continued attempt of voiding) network. Concurrent UDS testing is still necessary for studying the effects of strong desire to void and initiation of voiding (or attempt at initiation of voiding).
Sections du résumé
BACKGROUND
BACKGROUND
Several studies have reported brain activations and functional connectivity (FC) during micturition using functional magnetic resonance imaging (fMRI) and concurrent urodynamics (UDS) testing. However, due to the invasive nature of UDS procedure, non-invasive resting-state fMRI is being explored as a potential alternative. The purpose of this study is to evaluate the feasibility of utilizing resting states as a non-invasive alternative for investigating the bladder-related networks in the brain.
METHODS
METHODS
We quantitatively compared FC in brain regions belonging to the bladder-related network during the following states: 'strong desire to void', 'voiding initiation (or attempt at voiding initiation)', and 'voiding (or continued attempt of voiding)' with FC during rest in nine multiple sclerosis women with voiding dysfunction using fMRI data acquired at 7 T and 3 T.
RESULTS
RESULTS
The inter-subject correlation analysis showed that voiding (or continued attempt of voiding) is achieved through similar network connections in all subjects. The task-based bladder-related network closely resembles the resting-state intrinsic network only during voiding (or continued attempt of voiding) process but not at other states.
CONCLUSION
CONCLUSIONS
Resting states fMRI can be potentially utilized to accurately reflect the voiding (or continued attempt of voiding) network. Concurrent UDS testing is still necessary for studying the effects of strong desire to void and initiation of voiding (or attempt at initiation of voiding).
Identifiants
pubmed: 33512570
doi: 10.1007/s00345-021-03599-4
pii: 10.1007/s00345-021-03599-4
pmc: PMC8344374
mid: NIHMS1726073
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3525-3531Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK118209
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23DK118209
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23DK118209
Pays : United States
Informations de copyright
© 2021. The Author(s).
Références
Stoffel JT (2010) Contemporary management of the neurogenic bladder for multiple sclerosis patients. Urol Clin North Am 37(4):547–557
doi: 10.1016/j.ucl.2010.06.003
Panicker JN, Fowler CJ, Kessler TM (2015) Lower urinary tract dysfunction in the neurological patient: clinical assessment and management. Lancet Neurol 14(7):720–732
doi: 10.1016/S1474-4422(15)00070-8
Ogawa S et al (1990) Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 87(24):9868–9872
doi: 10.1073/pnas.87.24.9868
Biswal B et al (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34(4):537–541
doi: 10.1002/mrm.1910340409
Chaimow D et al (2018) Spatial specificity of the functional MRI blood oxygenation response relative to neuronal activity. Neuroimage 164:32–47
doi: 10.1016/j.neuroimage.2017.08.077
Shi Z et al (2017) High spatial correspondence at a columnar level between activation and resting state fMRI signals and local field potentials. Proc Natl Acad Sci U S A 114(20):5253–5258
doi: 10.1073/pnas.1620520114
Khavari R et al (2017) Functional Magnetic Resonance Imaging with Concurrent Urodynamic Testing Identifies Brain Structures Involved in Micturition Cycle in Patients with Multiple Sclerosis. J Urol 197(2):438–444
doi: 10.1016/j.juro.2016.09.077
Yin Y et al (2006) Cerebral activation during withholding urine with full bladder in healthy men using 99mTc-HMPAO SPECT. J Nucl Med 47(7):1093–1098
pubmed: 16818942
Blok BF, Sturms LM, Holstege G (1998) Brain activation during micturition in women. Brain 121(Pt 11):2033–2042
doi: 10.1093/brain/121.11.2033
Seseke S et al (2006) Voluntary pelvic floor muscle control–an fMRI study. Neuroimage 31(4):1399–1407
doi: 10.1016/j.neuroimage.2006.02.012
Shy M et al (2014) Functional magnetic resonance imaging during urodynamic testing identifies brain structures initiating micturition. J Urol 192(4):1149–1154
doi: 10.1016/j.juro.2014.04.090
Schrum A et al (2011) Motor cortical representation of the pelvic floor muscles. J Urol 186(1):185–190
doi: 10.1016/j.juro.2011.03.001
Blok BF, Sturms LM, Holstege G (1997) A PET study on cortical and subcortical control of pelvic floor musculature in women. J Comp Neurol 389(3):535–544
doi: 10.1002/(SICI)1096-9861(19971222)389:3<535::AID-CNE12>3.0.CO;2-K
Michels L et al (2015) Supraspinal Control of Urine Storage and Micturition in Men-An fMRI Study. Cereb Cortex 25(10):3369–3380
doi: 10.1093/cercor/bhu140
Zhang H et al (2005) An fMRI study of the role of suprapontine brain structures in the voluntary voiding control induced by pelvic floor contraction. Neuroimage 24(1):174–180
doi: 10.1016/j.neuroimage.2004.08.027
Kuhtz-Buschbeck JP et al (2005) Cortical representation of the urge to void: A functional magnetic resonance imaging study. J Urol 174(4):1477–1481
doi: 10.1097/01.ju.0000173007.84102.7c
Drake MJ et al (2010) Neural control of the lower urinary and gastrointestinal tracts: supraspinal CNS mechanisms. Neurourol Urodyn 29(1):119–127
doi: 10.1002/nau.20841
Sakakibara R (2015) Lower urinary tract dysfunction in patients with brain lesions. Handb Clin Neurol 130:269–287
doi: 10.1016/B978-0-444-63247-0.00015-8
Sekido N, Akaza H (1997) Neurogenic bladder may be a side effect of focus resection in an epileptic patient. Int J Urol 4(1):101–103
doi: 10.1111/j.1442-2042.1997.tb00152.x
Jang HJ, Kwon MJ, Cho KO (2018) Central Regulation of Micturition and Its Association With Epilepsy. Int Neurourol J 22(1):2–8
doi: 10.5213/inj.1836040.020
Blok BF, Willemsen AT, Holstege G (1997) A PET study on brain control of micturition in humans. Brain 120(Pt 1):111–121
doi: 10.1093/brain/120.1.111
Harvie C et al (2019) Brain activation during the voiding phase of micturition in healthy adults: A meta-analysis of neuroimaging studies. Clin Anat 32(1):13–19
doi: 10.1002/ca.23244
Alstott J et al (2009) Modeling the impact of lesions in the human brain. PLoS Comput Biol 5(6):e1000408
doi: 10.1371/journal.pcbi.1000408
Griffiths D et al (2007) Cerebral control of the bladder in normal and urge-incontinent women. Neuroimage 37(1):1–7
doi: 10.1016/j.neuroimage.2007.04.061
Tadic SD et al (2008) Abnormal connections in the supraspinal bladder control network in women with urge urinary incontinence. Neuroimage 39(4):1647–1653
doi: 10.1016/j.neuroimage.2007.10.059
Griffiths D (2015) Neural control of micturition in humans: a working model. Nat Rev Urol 12(12):695–705
doi: 10.1038/nrurol.2015.266
Shi Z et al (2016) Realistic models of apparent dynamic changes in resting-state connectivity in somatosensory cortex. Hum Brain Mapp 37(11):3897–3910
doi: 10.1002/hbm.23284
Chang C, Glover GH (2010) Time-frequency dynamics of resting-state brain connectivity measured with fMRI. Neuroimage 50(1):81–98
doi: 10.1016/j.neuroimage.2009.12.011
Shi Z et al (2019) On the Relationship between MRI and Local Field Potential Measurements of Spatial and Temporal Variations in Functional Connectivity. Sci Rep 9(1):8871
doi: 10.1038/s41598-019-45404-8
Khavari R et al (2020) Higher neural contribution underlying persistent lower urinary tract symptoms in men with Benign Prostatic Hyperplasia undergoing bladder outlet procedures. Contemp Clin Trials Commun 17:100498
doi: 10.1016/j.conctc.2019.100498