Clinical management of patients with genetic obesity during COVID-19 pandemic: position paper of the ESE Growth & Genetic Obesity COVID-19 Study Group and Rare Endo-ERN main thematic group on Growth and Obesity.
COVID-19
Genetic obesity
Monogenic obesity
Obesity syndrome
SARS-CoV-2
Journal
Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
27
10
2020
accepted:
08
01
2021
pubmed:
30
1
2021
medline:
24
4
2021
entrez:
29
1
2021
Statut:
ppublish
Résumé
This article aims to provide guidance on prevention and treatment of COVID-19 in patients with genetic obesity. Key principals of the management of patients with genetic obesity during COVID-19 pandemic for patients that have contracted COVID-19 are to be aware of: possible adrenal insufficiency (e.g., POMC deficiency, PWS); a more severe course in patients with concomitant immunodeficiency (e.g., LEP and LEPR deficiency), although defective leptin signalling could also be protective against the pro-inflammatory phenotype of COVID-19; disease severity being masked by insufficient awareness of symptoms in syndromic obesity patients with intellectual deficit (in particular PWS); to adjust medication dose to increased body size, preferably use dosing in m2; the high risk of malnutrition in patients with Sars-Cov2 infection, even in case of obesity. Key principals of the obesity management during the pandemic are to strive for optimal obesity management and a healthy lifestyle within the possibilities of the regulations to prevent weight (re)gain and to address anxiety within consultations, since prevalence of anxiety for COVID-19 is underestimated.
Identifiants
pubmed: 33512658
doi: 10.1007/s12020-021-02619-y
pii: 10.1007/s12020-021-02619-y
pmc: PMC7845285
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
653-662Références
World Health Organization, WHO coronavirus disease (COVID-19) Dashboard (2020). https://covid19.who.int/ . Accessed 2 Oct 2020
J. Zhu, P. Ji, J. Pang, Z. Zhong, H. Li, C. He, J. Zhang, C. Zhao, Clinical characteristics of 3062 COVID-19 patients: A meta-analysis. J Med Virol (2020). https://doi.org/10.1002/jmv.25884
A. Bhasin,H. Nam, C. Yeh, J. Lee, D. Liebovitz, C. Achenbach, Is BMI higher in younger patients with COVID-19? Association between BMI and COVID-19 hospitalization by age. Obesity (2020). https://doi.org/10.1002/oby.22947
Q. Cai, F. Chen, T. Wang, F. Luo, X. Liu, Q. Wu, Q. He, Z. Wang, Y. Liu, L. Liu, J. Chen, L. Xu, Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. Diabetes Care 43(7), 1392–1398 (2020). https://doi.org/10.2337/dc20-0576 . dc20-0576 [pii]
doi: 10.2337/dc20-0576
pubmed: 32409502
J. Lighter, M. Phillips, S. Hochman, S. Sterling, D. Johnson, F. Francois, A. Stachel, Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission. Clin. Infect. Dis. 5818333 [pii] (2020). https://doi.org/10.1093/cid/ciaa415
G. Onder, G. Rezza, S. Brusaferro, Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA (2020), https://doi.org/10.1001/jama.2020.4683
C.M. Petrilli, S.A. Jones, J. Yang, H. Rajagopalan, L. O’Donnell, Y. Chernyak, K.A. Tobin, R.J. Cerfolio, F. Francois, L.I. Horwitz, Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ 369, m1966 (2020). https://doi.org/10.1136/bmj.m1966
doi: 10.1136/bmj.m1966
pubmed: 32444366
pmcid: 7243801
K. Clement, H. Mosbah, C. Poitou, Rare genetic forms of obesity: from gene to therapy. Physiol. Behav. 227, 113134 (2020). https://doi.org/10.1016/j.physbeh.2020.113134 .
doi: 10.1016/j.physbeh.2020.113134
pubmed: 32805220
L. Kleinendorst, O. Abawi, H.J. van der Kamp, M. Alders, H.E.J. Meijers-Heijboer, E.F.C. van Rossum, E.L.T. van den Akker, M.M. van Haelst, Leptin receptor deficiency: a systematic literature review and prevalence estimation based on population genetics. Eur. J. Endocrinol. 182(1), 47–56 (2020). https://doi.org/10.1530/EJE-19-0678 . EJE-19-0678 [pii]
doi: 10.1530/EJE-19-0678
pubmed: 31658438
H. Krude, A. Gruters, Implications of proopiomelanocortin (POMC) mutations in humans: the POMC deficiency syndrome. Trends Endocrinol. Metab. 11(1), 15–22 (2000). https://doi.org/10.1016/s1043-2760(99)00213-1
doi: 10.1016/s1043-2760(99)00213-1
pubmed: 10652501
L. Pepin, E. Colin, M. Tessarech, S. Rouleau, N. Bouhours-Nouet, D. Bonneau, R. Coutant, A new case of PCSK1 pathogenic variant with congenital proprotein convertase 1/3 deficiency and literature review. J. Clin. Endocrinol. Metab. 104(4), 985–993 (2019). https://doi.org/10.1210/jc.2018-01854 . 5148135 [pii]
doi: 10.1210/jc.2018-01854
pubmed: 30383237
I.S. Farooqi, T. Wangensteen, S. Collins, W. Kimber, G. Matarese, J.M. Keogh, E. Lank, B. Bottomley, J. Lopez-Fernandez, I. Ferraz-Amaro, M.T. Dattani, O. Ercan, A.G. Myhre, L. Retterstol, R. Stanhope, J.A. Edge, S. McKenzie, N. Lessan, M. Ghodsi, V. De Rosa, F. Perna, S. Fontana, I. Barroso, D.E. Undlien, S. O’Rahilly, Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N. Engl. J. Med. 356(3), 237–247 (2007). https://doi.org/10.1056/NEJMoa063988
doi: 10.1056/NEJMoa063988
pubmed: 17229951
pmcid: 2670197
A. Nunziata, J.B. Funcke, G. Borck, J. von Schnurbein, S. Brandt, B. Lennerz, B. Moepps, P. Gierschik, P. Fischer-Posovszky, M. Wabitsch, Functional and phenotypic characteristics of human leptin receptor mutations. J. Endocr. Soc. 3(1), 27–41 (2019). https://doi.org/10.1210/js.2018-00123js_201800123[pii]
doi: 10.1210/js.2018-00123js_201800123[pii]
pubmed: 30560226
L. Kleinendorst, O. Abawi, B. van der Voorn, M. Jongejan, A.E. Brandsma, J.A. Visser, E.F.C. van Rossum, B. van der Zwaag, M. Alders, E.M.J. Boon, M.M. van Haelst, E.L.T. van den Akker, Identifying underlying medical causes of pediatric obesity: results of a systematic diagnostic approach in a pediatric obesity center. PLoS ONE 15(5), e0232990 (2020). https://doi.org/10.1371/journal.pone.0232990
doi: 10.1371/journal.pone.0232990
pubmed: 32384097
pmcid: 7209105
L. Kleinendorst, M.M. van Haelst, E.L.T. van den Akker, Genetics of Obesity. In: Igaz P., Patócs A. (eds) Genetics of Endocrine Diseases and Syndromes. Experientia Supplementum, vol 111. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-25905-1_19
Y. Kaur, R.J. de Souza, W.T. Gibson, D. Meyre, A systematic review of genetic syndromes with obesity. Obes. Rev. 18(6), 603–634 (2017). https://doi.org/10.1111/obr.12531
doi: 10.1111/obr.12531
pubmed: 28346723
R. Bachmann-Gagescu, H.C. Mefford, C. Cowan, G.M. Glew, A.V. Hing, S. Wallace, P.I. Bader, A. Hamati, P.J. Reitnauer, R. Smith, D.W. Stockton, H. Muhle, I. Helbig, E.E. Eichler, B.C. Ballif, J. Rosenfeld, K.D. Tsuchiya, Recurrent 200-kb deletions of 16p11.2 that include the SH2B1 gene are associated with developmental delay and obesity. Genet. Med. 12(10), 641–647 (2010). https://doi.org/10.1097/GIM.0b013e3181ef4286
doi: 10.1097/GIM.0b013e3181ef4286
pubmed: 20808231
C.F. Rocha, C.L. Paiva, Prader-Willi-like phenotypes: a systematic review of their chromosomal abnormalities. Genet Mol. Res. 13(1), 2290–2298 (2014). https://doi.org/10.4238/2014.March.31.9
doi: 10.4238/2014.March.31.9
pubmed: 24737477
K. Clement, H. Biebermann, I.S. Farooqi, L. Van der Ploeg, B. Wolters, C. Poitou, L. Puder, F. Fiedorek, K. Gottesdiener, G. Kleinau, N. Heyder, P. Scheerer, U. Blume-Peytavi, I. Jahnke, S. Sharma, J. Mokrosinski, S. Wiegand, A. Muller, K. Weiss, K. Mai, J. Spranger, A. Gruters, O. Blankenstein, H. Krude, P: Kuhnen, MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency. Nat. Med. 24(5), 551–555 (2018). https://doi.org/10.1038/s41591-018-0015-9[pii]
doi: 10.1038/s41591-018-0015-9[pii]
pubmed: 29736023
C.M.H. Poitou, K. Clement, Update on treatments for patients with genetic obesity. Eur. J. Endocrinol. 183(5), R149–R166 (2020)
doi: 10.1530/EJE-20-0363
E.W. Iepsen, J. Zhang, H.S. Thomsen, E.L. Hansen, M. Hollensted, S. Madsbad, T. Hansen, J.J. Holst, J.C. Holm, S.S. Torekov, Patients with obesity caused by melanocortin-4 receptor mutations can be treated with a glucagon-like peptide-1 receptor agonist. Cell Metab. 28(1), 23–32 e23 (2018). https://doi.org/10.1016/j.cmet.2018.05.008 . S1550-4131(18)30315-2 [pii]
doi: 10.1016/j.cmet.2018.05.008
pubmed: 29861388
Orphanet, Orphanet classification of rare endocrine diseases (2020). https://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=193&PatId=11118&search=Disease_Classif_Simple&new=1 . Accessed 30 Sep 2020
E. Denova-Gutierrez, H. Lopez-Gatell, J.L. Alomia-Zegarra, R. Lopez-Ridaura, C.A. Zaragoza-Jimenez, D.D. Dyer-Leal, R. Cortes-Alcala, T. Villa-Reyes, R. Gutierrez-Vargas, K. Rodriguez-Gonzalez, C. Escondrillas-Maya, T. Barrientos-Gutierrez, J.A. Rivera, S. Barquera, The association of obesity, type 2 diabetes, and hypertension with severe coronavirus disease 2019 on admission among Mexican patients. Obesity (2020). https://doi.org/10.1002/oby.22946
T.H. Chang, C.C. Chou, L.Y. Chang, Effect of obesity and body mass index on coronavirus disease 2019 severity: A systematic review and meta-analysis. Obes. Rev. 21(11), e13089 (2020). https://doi.org/10.1111/obr.13089
doi: 10.1111/obr.13089
pubmed: 32929833
B.M. Popkin, S. Du, W.D. Green, M.A. Beck, T. Algaith, C.H. Herbst, R.F. Alsukait, M. Alluhidan, N. Alazemi, M. Shekar, Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships. Obes. Rev. 21(11), e13128 (2020). https://doi.org/10.1111/obr.13128
doi: 10.1111/obr.13128
pubmed: 32845580
A. Hussain, K. Mahawar, Z. Xia, W. Yang, S. El-Hasani, Obesity and mortality of COVID-19. Meta-analysis. Obes. Res. Clin. Pract. (2020). S1871-403X(20)30550-0 [pii]. https://doi.org/10.1016/j.orcp.2020.07.002
S. Czernichow, N. Beeker, C. Rives-Lange, E. Guerot, J.L. Diehl, S. Katsahian, J.S. Hulot, T. Poghosyan, C. Carette, A. Sophie Jannot, A.-H.U.I.C.-r. collaboration, A.-H.C.C. Initiative, Obesity doubles mortality in patients hospitalized for SARS-CoV-2 in Paris hospitals, France: a cohort study on 5795 patients. Obesity (2020). https://doi.org/10.1002/oby.23014
D.A. Kass, P. Duggal, O. Cingolani, Obesity could shift severe COVID-19 disease to younger ages. Lancet 395(10236), 1544–1545 (2020). https://doi.org/10.1016/S0140-6736(20)31024-2 .
doi: 10.1016/S0140-6736(20)31024-2
pubmed: 32380044
pmcid: 7196905
J.F. Ludvigsson, Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 109(6), 1088–1095 (2020). https://doi.org/10.1111/apa.15270
doi: 10.1111/apa.15270
pubmed: 32202343
P. Zachariah, C.L. Johnson, K.C. Halabi, D. Ahn, A.I. Sen, A. Fischer, S.L. Banker, M. Giordano, C.S. Manice, R. Diamond, T.B. Sewell, A.J. Schweickert, J.R. Babineau, R.C. Carter, D.B. Fenster, J.S. Orange, T.A. McCann, S.G. Kernie, L. Saiman, C.-M.G Columbia Pediatric, Epidemiology, clinical features, and disease severity in patients with coronavirus disease 2019 (COVID-19) in a Children’s Hospital in New York City, New York. JAMA Pediatr (2020). https://doi.org/10.1001/jamapediatrics.2020.2430
A. Simonnet, M. Chetboun, J. Poissy, V. Raverdy, J. Noulette, A. Duhamel, J. Labreuche, D. Mathieu, F. Pattou, M. Jourdain; Licorn the Lille COVID-19 and Obesity study Group, High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity 28(7), 1195–1199 (2020). https://doi.org/10.1002/oby.22831
doi: 10.1002/oby.22831
pubmed: 32271993
J. Toubiana, C. Poirault, A. Corsia, F. Bajolle, J. Fourgeaud, F. Angoulvant, A. Debray, R. Basmaci, E. Salvador, S. Biscardi, P. Frange, M. Chalumeau, J.L. Casanova, J.F. Cohen, S. Allali, Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ 369, m2094 (2020). https://doi.org/10.1136/bmj.m2094
doi: 10.1136/bmj.m2094
pubmed: 32493739
pmcid: 7500538
M. Ahmed, S. Advani, A. Moreira, S. Zoretic, J. Martinez, K. Chorath, S. Acosta, R. Naqvi, F. Burmeister-Morton, F. Burmeister, A. Tarriela, M. Petershack, M. Evans, A. Hoang, K. Rajasekaran, S. Ahuja, A. Moreira, Multisystem inflammatory syndrome in children: a systematic review. EClinicalMedicine (2020). https://doi.org/10.1016/j.eclinm.2020.100527
C. Venkata, P. Sampathkumar, B. Afessa, Hospitalized patients with 2009 H1N1 influenza infection: the Mayo Clinic experience. Mayo Clin. Proc. 85(9), 798–805 (2010). https://doi.org/10.4065/mcp.2010.0166
doi: 10.4065/mcp.2010.0166
pubmed: 20664021
pmcid: 2931615
U. Radzikowska, M. Ding, G. Tan, D. Zhakparov, Y. Peng, P. Wawrzyniak, M. Wang, S. Li, H. Morita, H., Altunbulakli, M. Reiger, A.U. Neumann, N. Lunjani, C. Traidl-Hoffmann, K.C. Nadeau, L. O’Mahony, C. Akdis, M. Sokolowska, Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors. Allergy (2020). https://doi.org/10.1111/all.14429
P.M. Ryan, N.M. Caplice, Is adipose tissue a reservoir for viral spread, immune activation, and cytokine amplification in coronavirus disease 2019? Obesity 28(7), 1191–1194 (2020). https://doi.org/10.1002/oby.22843
doi: 10.1002/oby.22843
pubmed: 32314868
G.H. Goossens, D. Dicker, N.J. Farpour-Lambert, G. Fruhbeck, D. Mullerova, E. Woodward, J.C. Holm, Obesity and COVID-19: a perspective from the European Association for the Study of Obesity on Immunological Perturbations, Therapeutic Challenges, and Opportunities in Obesity. Obes. Facts, 1–14 (2020). https://doi.org/10.1159/000510719
L. Fontana, J.C. Eagon, M.E. Trujillo, P.E. Scherer, S. Klein, Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56(4), 1010–1013 (2007). https://doi.org/10.2337/db06-1656 . db06-1656 [pii]
doi: 10.2337/db06-1656
pubmed: 17287468
V. Mohamed-Ali, S. Goodrick, A. Rawesh, D.R. Katz, J.M. Miles, J.S. Yudkin, S. Klein, S.W. Coppack, Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J. Clin. Endocrinol. Metab. 82(12), 4196–4200 (1997). https://doi.org/10.1210/jcem.82.12.4450
doi: 10.1210/jcem.82.12.4450
pubmed: 9398739
I.Y. Chen, M. Moriyama, M.F. Chang, T. Ichinohe, Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome. Front. Microbiol. 10, 50 (2019). https://doi.org/10.3389/fmicb.2019.00050
doi: 10.3389/fmicb.2019.00050
pubmed: 30761102
pmcid: 6361828
J. Rheinheimer, B.M. de Souza, N.S. Cardoso, A.C. Bauer, D. Crispim, Current role of the NLRP3 inflammasome on obesity and insulin resistance: a systematic review. Metabolism 74, 1–9 (2017). https://doi.org/10.1016/j.metabol.2017.06.002
doi: 10.1016/j.metabol.2017.06.002
pubmed: 28764843
K. van der Weerd, W.A. Dik, B. Schrijver, D.H. Schweitzer, A.W. Langerak, H.A. Drexhage, R.M. Kiewiet, M.O. van Aken, A. van Huisstede, J.J. van Dongen, A.J. van der Lelij, F.J. Staal, P.M. van Hagen, Morbidly obese human subjects have increased peripheral blood CD4+T cells with skewing toward a Treg- and Th2-dominated phenotype. Diabetes 61(2), 401–408 (2012). https://doi.org/10.2337/db11-1065
doi: 10.2337/db11-1065
pubmed: 22228716
pmcid: 3266399
N. Sattar, I.B. McInnes, J.J.V. McMurray, Obesity is a risk factor for severe COVID-19 infection: multiple potential mechanisms. Circulation 142(1), 4–6 (2020). https://doi.org/10.1161/CIRCULATIONAHA.120.047659
doi: 10.1161/CIRCULATIONAHA.120.047659
pubmed: 32320270
H.E. Maier, R. Lopez, N. Sanchez, S. Ng, L. Gresh, S. Ojeda, R. Burger-Calderon, G. Kuan, E. Harris, A. Balmaseda, A. Gordon, Obesity increases the duration of influenza A virus shedding in adults. J. Infect. Dis. 218(9), 1378–1382 (2018). https://doi.org/10.1093/infdis/jiy370 .
doi: 10.1093/infdis/jiy370
pubmed: 30085119
pmcid: 6151083
J. Yan, M. Grantham, J. Pantelic, P.J. Bueno de Mesquita, B. Albert, F. Liu, S. Ehrman, D.K. Milton; Consortium, E., Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community. Proc. Natl Acad. Sci. USA 115(5), 1081–1086 (2018). https://doi.org/10.1073/pnas.1716561115 . 1716561115 [pii]
doi: 10.1073/pnas.1716561115
pubmed: 29348203
E.A. Karlsson, T. Hertz, C. Johnson, A. Mehle, F. Krammer, S. Schultz-Cherry, Obesity outweighs protection conferred by adjuvanted influenza vaccination. mBio 7(4) (2016). https://doi.org/10.1128/mBio.01144-16
L. Luzi, M.G. Radaelli, Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic. Acta Diabetol. 57(6), 759–764 (2020). https://doi.org/10.1007/s00592-020-01522-8 . 10.1007/s00592-020-01522-8 [pii]
doi: 10.1007/s00592-020-01522-8
pubmed: 32249357
A.E. Dixon, U. Peters, The effect of obesity on lung function. Expert Rev. Respir. Med. 12(9), 755–767 (2018). https://doi.org/10.1080/17476348.2018.1506331
doi: 10.1080/17476348.2018.1506331
pubmed: 30056777
pmcid: 6311385
P. Bel Lassen, C. Poitou, L. Genser, F. Marchelli, J. Aron-Wisnewsky, C. Ciangura, F. Jacques, P. Moreau, NutriOmics investigators., J.M. Oppert, K. Clement, COVID-19 and its severity in bariatric surgery operated patients. Obesity (2020). https://doi.org/10.1002/oby.23026
IPWSO: Early results from IPWSO’s PWS and COVID-19 survey (2020), https://www.ipwso.org/post/early-results-from-ipwso-s-pws-and-covid-19-survey . Accessed 30 Sep 2020
D. Fintini, G. Grugni, S. Bocchini, C. Brufani, S. Di Candia, A. Corrias, M. Delvecchio, A. Salvatoni, L. Ragusa, N. Greggio, A. Franzese, E. Scarano, G. Trifiro, L. Mazzanti, G. Chiumello, M. Cappa, A. Crino; Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology, Disorders of glucose metabolism in Prader-Willi syndrome: results of a multicenter Italian cohort study. Nutr. Metab. Cardiovasc. Dis. 26(9), 842–847 (2016). https://doi.org/10.1016/j.numecd.2016.05.010 . S0939-4753(15)30206-4 [pii]
doi: 10.1016/j.numecd.2016.05.010
pubmed: 27381990
V. Laurier, A. Lapeyrade, P. Copet, G. Demeer, M. Silvie, E. Bieth, M. Coupaye, C. Poitou, F. Lorenzini, F. Labrousse, C. Molinas, M. Tauber, D. Thuilleaux, J. Jauregi, Medical, psychological and social features in a large cohort of adults with Prader-Willi syndrome: experience from a dedicated centre in France. J. Intellect. Disabil. Res. 59(5), 411–421 (2015). https://doi.org/10.1111/jir.12140
doi: 10.1111/jir.12140
pubmed: 24947991
S. Mujahid, K.F. Hunt, Y.S. Cheah, E. Forsythe, J.M. Hazlehurst, K. Sparks, S. Mohammed, J.W. Tomlinson, S.A. Amiel, P.V. Carroll, P.L. Beales, M.S.B. Huda, B.M. McGowan, The endocrine and metabolic characteristics of a large bardet-biedl syndrome clinic population. J. Clin. Endocrinol. Metab. 103(5), 1834–1841 (2018). https://doi.org/10.1210/jc.2017-01459 . 4834028 [pii]
doi: 10.1210/jc.2017-01459
pubmed: 29409041
J.C. Han, D.P. Reyes-Capo, C.Y. Liu, J.C. Reynolds, E. Turkbey, I.B. Turkbey, J. Bryant, J.D. Marshall, J.K. Naggert, W.A. Gahl, J.A. Yanovski, M. Gunay-Aygun, Comprehensive endocrine-metabolic evaluation of patients with alstrom syndrome compared With BMI-matched controls. J. Clin. Endocrinol. Metab. 103(7), 2707–2719 (2018). https://doi.org/10.1210/jc.2018-00496 . 4987161 [pii]
doi: 10.1210/jc.2018-00496
pubmed: 29718281
pmcid: 6276679
G.M. Nixon, R.T. Brouillette, Sleep and breathing in Prader-Willi syndrome. Pediatr. Pulmonol. 34(3), 209–217 (2002). https://doi.org/10.1002/ppul.10152
doi: 10.1002/ppul.10152
pubmed: 12203850
D. McSharry, A. Malhotra, Potential influences of obstructive sleep apnea and obesity on COVID-19 severity. J. Clin. Sleep. Med. 16(9), 1645 (2020). https://doi.org/10.5664/jcsm.8538
doi: 10.5664/jcsm.8538
pubmed: 32356516
R. Faggioni, K.R. Feingold, C. Grunfeld, Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J. 15(14), 2565–2571 (2001). https://doi.org/10.1096/fj.01-0431rev15/14/2565[pii]
doi: 10.1096/fj.01-0431rev15/14/2565[pii]
pubmed: 11726531
R. Maurya, P. Bhattacharya, R. Dey, H.L. Nakhasi, Leptin functions in infectious diseases. Front. Immunol. 9, 2741 (2018). https://doi.org/10.3389/fimmu.2018.02741
doi: 10.3389/fimmu.2018.02741
pubmed: 30534129
pmcid: 6275238
M.G. Martin, I. Lindberg, R.S. Solorzano-Vargas, J. Wang, Y. Avitzur, R. Bandsma, C. Sokollik, S. Lawrence, L.A. Pickett, Z. Chen, O. Egritas, B. Dalgic, V. Albornoz, L. de Ridder, J. Hulst, F. Gok, A. Aydogan, A. Al-Hussaini, D.E. Gok, M. Yourshaw, S.V. Wu, G. Cortina, S. Stanford, S. Georgia, Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort. Gastroenterology 145(1), 138–148 (2013). https://doi.org/10.1053/j.gastro.2013.03.048 . S0016-5085(13)00489-7 [pii]
doi: 10.1053/j.gastro.2013.03.048
pubmed: 23562752
pmcid: 3719133
M.A. Angulo, M.G. Butler, M.E. Cataletto, Prader-Willi syndrome: a review of clinical, genetic, and endocrine findings. J. Endocrinol. Investig 38(12), 1249–1263 (2015). https://doi.org/10.1007/s40618-015-0312-9
doi: 10.1007/s40618-015-0312-9
P.M. Stewart, B.M. Biller, C. Marelli, C. Gunnarsson, M.P. Ryan, G. Johannsson, Exploring Inpatient hospitalizations and morbidity in patients with adrenal insufficiency. J. Clin. Endocrinol. Metab. 101(12), 4843–4850 (2016). https://doi.org/10.1210/jc.2016-2221
doi: 10.1210/jc.2016-2221
pubmed: 27623069
P. Burman, A.F. Mattsson, G. Johannsson, C. Hoybye, H. Holmer, P. Dahlqvist, K. Berinder, B.E. Engstrom, B. Ekman, E.M. Erfurth, J. Svensson, J. Wahlberg, F.A. Karlsson, Deaths among adult patients with hypopituitarism: hypocortisolism during acute stress, and de novo malignant brain tumors contribute to an increased mortality. J. Clin. Endocrinol. Metab. 98(4), 1466–1475 (2013). https://doi.org/10.1210/jc.2012-4059 . jc.2012-4059 [pii]
doi: 10.1210/jc.2012-4059
pubmed: 23457412
B.R. Brandt, I. Rosen, Impaired peripheral somatosensory function in children with Prader-Willi syndrome. Neuropediatrics 29(3), 124–126 (1998). https://doi.org/10.1055/s-2007-973547
doi: 10.1055/s-2007-973547
pubmed: 9706621
F. Mauvais-Jarvis, S.L. Klein, E.R. Levin, Estradiol, progesterone, immunomodulation, and COVID-19 outcomes. Endocrinology 161(9), 5879027 [pii] (2020). https://doi.org/10.1210/endocr/bqaa127
G. Rastrelli, V. Di Stasi, F. Inglese, M. Beccaria, M. Garuti, D. Di Costanzo, F. Spreafico, G.F. Greco, G. Cervi, A. Pecoriello, A. Magini, T. Todisco, S. Cipriani, E. Maseroli, G. Corona, A. Salonia, A. Lenzi, M. Maggi, G. De Donno, L. Vignozzi, Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients. Andrology (2020). https://doi.org/10.1111/andr.12821
A. Cagnacci, G. Bonaccorsi, M. Gambacciani; board of the Italian Menopause Society, Reflections and recommendations on the COVID-19 pandemic: should hormone therapy be discontinued? Maturitas 138, 76–77 (2020). https://doi.org/10.1016/j.maturitas.2020.05.022
doi: 10.1016/j.maturitas.2020.05.022
pubmed: 32565009
pmcid: 7301099
J.C. Wells, A.L. Sawaya, R. Wibaek, M. Mwangome, M.S. Poullas, C.S. Yajnik, A. Demaio, The double burden of malnutrition: aetiological pathways and consequences for health. Lancet 395(10217), 75–88 (2020). https://doi.org/10.1016/S0140-6736(19)32472-9
doi: 10.1016/S0140-6736(19)32472-9
pubmed: 31852605
D. Bedock, P. Bel Lassen, A. Mathian, P. Moreau, J. Couffignal, C. Ciangura, C. Poitou, A.C. Jeannin, H. Mosbah, J. Fadlallah, Z. Amoura, J.M. Oppert, P. Faucher, Prevalence and severity of malnutrition in hospitalized COVID-19 patients. Clin. Nutr. ESPEN (2020). https://doi.org/10.1016/j.clnesp.2020.09.018
R. Barazzoni, S.C. Bischoff, J. Breda, K. Wickramasinghe, Z. Krznaric, D. Nitzan, M. Pirlich, P. Singer; endorsed by the ESPEN Council, ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection. Clin. Nutr. 39(6), 1631–1638 (2020). https://doi.org/10.1016/j.clnu.2020.03.022
doi: 10.1016/j.clnu.2020.03.022
pubmed: 32305181
pmcid: 7138149
F. Chen, D. Zheng, J. Liu, Y. Gong, Z. Guan, D. Lou, Depression and anxiety among adolescents during COVID-19: a cross-sectional study. Brain Behav. Immun. 88, 36–38 (2020). https://doi.org/10.1016/j.bbi.2020.05.061 . S0889-1591(20)30891-6 [pii]
doi: 10.1016/j.bbi.2020.05.061
pubmed: 32464156
pmcid: 7247496
W.Y. Jiao, L.N. Wang, J. Liu, S.F. Fang, F.Y. Jiao, M. Pettoello-Mantovani, E. Somekh, Behavioral and emotional disorders in children during the COVID-19 epidemic. J. Pediatr. 221, 264–266 e261 (2020). https://doi.org/10.1016/j.jpeds.2020.03.013 . S0022-3476(20)30336-X [pii]
doi: 10.1016/j.jpeds.2020.03.013
pubmed: 32248989
pmcid: 7127630
O. Abawi, M.S. Welling, E. van den Eynde, E.F.C. van Rossum, J. Halberstadt, E.L.T. van den Akker, B. van der Voorn, COVID-19 related anxiety in children and adolescents with severe obesity: a mixed-methods study. Clin. Obes. e12412 (2020). https://doi.org/10.1111/cob.12412
A. Pietrobelli, L. Pecoraro, A. Ferruzzi, M. Heo, M. Faith, T. Zoller, F. Antoniazzi, G. Piacentini, S.N. Fearnbach, S.B. Heymsfield, Effects of COVID-19 lockdown on lifestyle behaviors in children with obesity living in Verona, Italy: a longitudinal study. Obesity 28(8), 1382–1385 (2020). https://doi.org/10.1002/oby.22861
doi: 10.1002/oby.22861
pubmed: 32352652