Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities.
Comorbidities
Cytokines
Inflammation
Interleukin-17
Interleukin-23
Psoriasis
Journal
Dermatology and therapy
ISSN: 2193-8210
Titre abrégé: Dermatol Ther (Heidelb)
Pays: Switzerland
ID NLM: 101590450
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
01
12
2020
pubmed:
30
1
2021
medline:
30
1
2021
entrez:
29
1
2021
Statut:
ppublish
Résumé
Psoriasis is an immune-mediated inflammatory skin disease associated with numerous inflammatory comorbidities, including increased cardiovascular risk. The interleukin (IL)-23/IL-17 axis plays a central role in the immunopathogenesis of psoriasis and related comorbidities by acting to stimulate keratinocyte hyperproliferation and feed-forwarding circuits of perpetual T cell-mediated inflammation. IL-17 plays an important role in the downstream portion of the psoriatic inflammatory cascade. This review discusses the distinct mechanisms of action of IL-17 and IL-23 in the immunopathogenesis of psoriasis and related comorbidities plus the significant therapeutic benefits of selectively inhibiting these cytokines in patients with moderate to severe plaque psoriasis.
Identifiants
pubmed: 33512665
doi: 10.1007/s13555-021-00483-2
pii: 10.1007/s13555-021-00483-2
pmc: PMC8019008
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
385-400Références
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