Aphanius fasciatus: a molecular model of scoliosis?
Aphanius fasciatus
Human idiopathic scoliosis
Natural model
Journal
Spine deformity
ISSN: 2212-1358
Titre abrégé: Spine Deform
Pays: England
ID NLM: 101603979
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
13
02
2020
accepted:
15
01
2021
pubmed:
30
1
2021
medline:
19
11
2021
entrez:
29
1
2021
Statut:
ppublish
Résumé
Observational study of Killifish with spinal deformities OBJECTIVE: To evaluate the morphology and molecular biology of Aphanius fasciatus with severe spine deformities. Idiopathic Scoliosis affects 3% of the population and is an abnormal three-dimensional curvature of the spine with unknown cause. The lack of a model system with naturally occurring spinal curvatures has hindered research on the etiology of IS. The Mediterranean killifish Aphanius fasciatus, collected from the coast of Sfax (Tunisia), which has an inborn skeletal deformity was chosen. We used morphologic features to evaluate the severity of scoliosis according to the different types and performed a biochemical analysis using factors previously studied in humans (estradiol, melatonin and Insulin Growth Factor 1 "IGF-1"). We have detected relevant molecular deviations that occur in Killifish deformities and the fish with severe scoliosis are smaller and less old than the ones with milder scolioses. Furthermore, a significant change in levels of ovarian estradiol, liver IGF-1 and brain melatonin was noted between deformed and normal fish. Aphanius fasciatus could be used as a molecular model system to study the etiology of IS in humans as the characterization of the Aphanius fasciatus scoliosis syndrome has revealed morphological and biochemical parallels to IS. However, it is important to note the limitations of the proposed model, including the short lifespan of the fish. III.
Identifiants
pubmed: 33512704
doi: 10.1007/s43390-021-00291-w
pii: 10.1007/s43390-021-00291-w
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
883-892Informations de copyright
© 2021. Scoliosis Research Society.
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