Glucosuric, renal and haemodynamic effects of licogliflozin, a dual inhibitor of sodium-glucose co-transporter-1 and sodium-glucose co-transporter-2, in patients with chronic kidney disease: A randomized trial.
drug mechanism
phase I-II study
Journal
Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
18
01
2021
received:
17
10
2020
accepted:
23
01
2021
pubmed:
30
1
2021
medline:
10
7
2021
entrez:
29
1
2021
Statut:
ppublish
Résumé
To investigate the glucosuric, renal and haemodynamic effects of licogliflozin, a dual sodium-glucose co-transporter-1 and sodium-glucose co-transporter-2 inhibitor, in patients with chronic kidney disease (CKD). This multiple-dose, parallel-group, phase II mechanistic study randomized 53 participants (aged 18-78 years, body mass index ≤ 50 kg/m Licogliflozin treatment for 7 days significantly (p < .01) increased UGE Licogliflozin treatment results in significantly increased UGE and favourable changes in urinary electrolytes and haemodynamics in patients with varying degrees of CKD (estimated glomerular filtration rate ≥ 45 mL/min/1.73 m
Substances chimiques
Anhydrides
0
Sodium-Glucose Transporter 2
0
Sorbitol
506T60A25R
licogliflozin
57J06X6EI0
Sodium
9NEZ333N27
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1182-1190Subventions
Organisme : This study was funded by Novartis Institutes for BioMedical Research.
Organisme : Novartis Institutes for BioMedical Research
Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
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