Novelty seeking is associated with increased body weight and orbitofrontal grey matter volume reduction.
BMI
MRI
Novelty seeking
Overweight
Tridimensional Personality Questionnaire
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
07
08
2020
revised:
18
01
2021
accepted:
18
01
2021
pubmed:
30
1
2021
medline:
22
12
2021
entrez:
29
1
2021
Statut:
ppublish
Résumé
Novelty seeking (NS) has previously been identified as a personality trait that is associated with elevated body mass index (BMI) and obesity. Of note, both obesity and reduced impulse control - a core feature of NS - have previously been associated with grey matter volume (GMV) reductions in the orbitofrontal cortex (OFC). Yet, it remains unknown, if body weight-related grey matter decline in the OFC might be explained by higher levels of NS. To address this question, we studied associations between NS, BMI and brain structure in 355 healthy subjects. Brain images were pre-processed using voxel-based morphometry (VBM). BMI was calculated from self-reported height and weight. The Tridimensional Personality Questionnaire (TPQ) was used to assess NS. NS and BMI were associated positively (r = .137, p = .01) with NS being a significant predictor of BMI (B = 0.172; SE B = 0.05; ß = 0.184; p = 0.001). Significant associations between BMI and GMV specifically in the OFC (x = -44, y = 56, z = -2, t(350) = 4.34, k = 5, p
Identifiants
pubmed: 33513455
pii: S0306-4530(21)00022-6
doi: 10.1016/j.psyneuen.2021.105148
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105148Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.