Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance.

ATP Binding Cassette Transporter, Subfamily B / antagonists & inhibitors Antineoplastic Agents / pharmacology Biological Transport Drug Resistance, Neoplasm / drug effects Humans
ABC transporter Cancer chemotherapy MRP Multidrug resistance protein

Journal

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
ISSN: 1532-2084
Titre abrégé: Drug Resist Updat
Pays: Scotland
ID NLM: 9815369

Informations de publication

Date de publication:
01 2021
Historique:
received: 16 10 2020
revised: 21 12 2020
accepted: 25 12 2020
pubmed: 30 1 2021
medline: 25 12 2021
entrez: 29 1 2021
Statut: ppublish

Résumé

ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally and mechanistically distinct substrates against steep concentration gradients. Among the seven human ABC subfamilies namely ABCA-ABCG, ABCC is the largest subfamily with 13 members. In this respect, 9 of the ABCC members are termed "multidrug resistance proteins" (MRPs1-9) due to their ability to mediate cancer multidrug resistance (MDR) by extruding various chemotherapeutic agents or their metabolites from tumor cells. Furthermore, MRPs are also responsible for the ATP-driven efflux of physiologically important organic anions such as leukotriene C

Identifiants

DOI: 10.1016/j.drup.2021.100743 PMID: 33513557
pubmed: 33513557
pii: S1368-7646(21)00001-7
doi: 10.1016/j.drup.2021.100743
pii:
doi:

Substances chimiques

ATP Binding Cassette Transporter, Subfamily B 0
Antineoplastic Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100743

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Jing-Quan Wang (JQ)

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.

Yuqi Yang (Y)

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.

Chao-Yun Cai (CY)

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.

Qiu-Xu Teng (QX)

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.

Qingbin Cui (Q)

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA; School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong 511436, China; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.

Jun Lin (J)

Department of Anesthesiology, Stony Brook University Health Sciences Center, Stony Brook, NY, 11794, USA.

Yehuda G Assaraf (YG)

The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.

Zhe-Sheng Chen (ZS)

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA. Electronic address: chenz@stjohns.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Sous-famille B de transporteurs à cassette liant l'ATP › Multidrug resistance proteins (MRPs):...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Multidrug resistance proteins (MRPs):...
questionsmedicales.fr › Métabolisme › Transport biologique › Multidrug resistance proteins (MRPs):...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Multidrug resistance proteins (MRPs):...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multidrug resistance proteins (MRPs):...