T2-high Asthma, Classified by Sputum mRNA Expression of
IL-13
IL-4
IL-5
T2 gene mean
T2-high asthma
asthma
biological treatment
endotype
eosinophilic
gene expression
severe asthma
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
27 Jan 2021
27 Jan 2021
Historique:
received:
31
12
2020
revised:
25
01
2021
accepted:
25
01
2021
entrez:
30
1
2021
pubmed:
31
1
2021
medline:
31
1
2021
Statut:
epublish
Résumé
Asthma is a common chronic disease, with different underlying inflammatory mechanisms. Identification of asthma endotypes, which reflect a variable response to different treatments, is important for more precise asthma management. T2 asthma is characterized by airway inflammation driven by T2 cytokines including interleukins IL-4, IL-5, and IL-13. This study aimed to determine whether induced sputum samples can be used for gene expression profiling of T2-high asthma classified by
Identifiants
pubmed: 33513844
pii: life11020092
doi: 10.3390/life11020092
pmc: PMC7911289
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : P3-0360
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