Human Saliva-Mediated Hydrolysis of Eugenyl-β-D-Glucoside and Fluorescein-di-β-D-Glucoside in In Vivo and In Vitro Models.
Anti-Bacterial Agents
/ pharmacology
Chromatography, Liquid
Fluorescein
/ chemistry
Gastrointestinal Tract
/ metabolism
Glucosides
/ chemistry
Healthy Volunteers
Humans
Hydrolysis
In Vitro Techniques
Kefir
Kinetics
Saliva
/ metabolism
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Tandem Mass Spectrometry
beta-Glucosidase
/ metabolism
human saliva
hydrolysis
β-glucosides
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
27 01 2021
27 01 2021
Historique:
received:
30
11
2020
revised:
17
01
2021
accepted:
20
01
2021
entrez:
30
1
2021
pubmed:
31
1
2021
medline:
24
7
2021
Statut:
epublish
Résumé
Eugenyl-β-D-glucopyranoside, also referred to as Citrusin C, is a natural glucoside found among others in cloves, basil and cinnamon plants. Eugenol in a form of free aglycone is used in perfumeries, flavourings, essential oils and in medicinal products. Synthetic Citrusin C was incubated with human saliva in several in vitro models together with substrate-specific enzyme and antibiotics (clindamycin, ciprofloxacin, amoxicillin trihydrate and potassium clavulanate). Citrusin C was detected using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Citrusin C was completely degraded only when incubated with substrate-specific
Identifiants
pubmed: 33514072
pii: biom11020172
doi: 10.3390/biom11020172
pmc: PMC7911702
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Glucosides
0
eugenylglucopyranoside
0
beta-Glucosidase
EC 3.2.1.21
Fluorescein
TPY09G7XIR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Polish Ministry of Science and Higher Education
ID : 2013/09/D/NZ9/03115
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