Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
04
06
2020
accepted:
11
12
2020
entrez:
30
1
2021
pubmed:
31
1
2021
medline:
20
4
2022
Statut:
epublish
Résumé
Slow progress in the fight against neurodegenerative diseases (NDs) motivates an urgent need for highly controlled in vitro systems to investigate organ-organ- and organ-immune-specific interactions relevant for disease pathophysiology. Of particular interest is the gut/microbiome-liver-brain axis for parsing out how genetic and environmental factors contribute to NDs. We have developed a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD). It connects microphysiological systems (MPSs) of the primary human gut and liver with a human induced pluripotent stem cell-derived cerebral MPS in a systemically circulated common culture medium containing CD4
Identifiants
pubmed: 33514545
pii: 7/5/eabd1707
doi: 10.1126/sciadv.abd1707
pmc: PMC7846169
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : R01 MH104610
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014051
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB021908
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034854
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES002109
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Références
Sci Rep. 2017 Feb 08;7:42296
pubmed: 28176881
J Transl Med. 2011 Jul 20;9:113
pubmed: 21774806
BMC Genomics. 2018 Apr 17;19(1):262
pubmed: 29665773
Gut. 1987 Oct;28(10):1221-7
pubmed: 3678950
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2047-52
pubmed: 12576551
Essays Biochem. 2018 Oct 26;62(4):607-617
pubmed: 30139877
Mov Disord. 2013 Jun;28(6):715-24
pubmed: 23589357
J Biol Chem. 2002 May 3;277(18):16116-23
pubmed: 11850416
Nat Rev Gastroenterol Hepatol. 2018 Sep;15(9):555-567
pubmed: 29844586
Mediators Inflamm. 2013;2013:434010
pubmed: 23533306
Dis Model Mech. 2012 Nov;5(6):746-55
pubmed: 23065638
Nat Biotechnol. 2017 Jun;35(6):569-576
pubmed: 28459449
Sci Rep. 2018 Jun 11;8(1):8868
pubmed: 29892006
Exp Neurol. 1996 Dec;142(2):313-22
pubmed: 8934562
Neuro Endocrinol Lett. 2014;35(7):586-93
pubmed: 25617881
Cell. 2017 Jun 15;169(7):1276-1290.e17
pubmed: 28602351
Sci Rep. 2018 Sep 26;8(1):14430
pubmed: 30258117
Cell Syst. 2020 Mar 25;10(3):223-239.e9
pubmed: 32191873
Lab Chip. 2018 Aug 21;18(17):2614-2631
pubmed: 30063238
Parkinsonism Relat Disord. 2016 Nov;32:66-72
pubmed: 27591074
Fluids Barriers CNS. 2019 Feb 5;16(1):4
pubmed: 30717760
J Neuroinflammation. 2013 Oct 07;10:122
pubmed: 24093540
Hum Mol Genet. 2003 Aug 15;12(16):1945-58
pubmed: 12913066
J Neurosci. 2005 Apr 13;25(15):3763-73
pubmed: 15829628
Front Immunol. 2017 May 18;8:531
pubmed: 28572801
Acta Neuropathol Commun. 2015 Dec 01;3:76
pubmed: 26621506
Lancet Neurol. 2011 Mar;10(3):230-40
pubmed: 21317042
Nat Rev Gastroenterol Hepatol. 2019 Aug;16(8):461-478
pubmed: 31123355
Sci Rep. 2017 Mar 27;7:45270
pubmed: 28345602
Mol Neurobiol. 2017 Dec;54(10):7762-7776
pubmed: 27844285
Curr Top Microbiol Immunol. 2002;265:119-40
pubmed: 12014186
Neurochem Int. 2017 Mar;104:34-48
pubmed: 28082232
Nature. 2016 May 5;533(7601):95-9
pubmed: 27096366
Front Neurol. 2019 Mar 26;10:280
pubmed: 30972011
Drug Metab Dispos. 2016 Dec;44(12):1940-1948
pubmed: 27621203
Biochim Biophys Acta. 2004 Nov 29;1695(1-3):235-47
pubmed: 15571819
Stem Cell Reports. 2017 Jun 6;8(6):1516-1524
pubmed: 28528700
Exp Ther Med. 2015 Jun;9(6):2047-2052
pubmed: 26136934
J Neurochem. 2011 Jan;116(2):164-76
pubmed: 21073468
Fluids Barriers CNS. 2018 Dec 4;15(1):32
pubmed: 30514389
J Neurosci. 2000 Aug 15;20(16):6048-54
pubmed: 10934254
Cells. 2018 Mar 10;7(3):
pubmed: 29534450
Front Neurosci. 2019 Mar 28;13:235
pubmed: 30983949
J Neurosci. 2008 Jan 2;28(1):264-78
pubmed: 18171944
Ann Neurol. 2011 Mar;69(3):570-80
pubmed: 21400565
Cell Mol Gastroenterol Hepatol. 2017 Nov 03;5(2):113-130
pubmed: 29693040
Sci Rep. 2017 Nov 6;7(1):14620
pubmed: 29097671
Cell Death Differ. 2011 Apr;18(4):602-18
pubmed: 20930850
Sci Rep. 2018 Mar 14;8(1):4530
pubmed: 29540740
Clin Exp Immunol. 1994 Oct;98(1):71-7
pubmed: 7923888
Gut Microbes. 2016 May 3;7(3):189-200
pubmed: 26963409
Microvasc Res. 2019 Mar;122:60-70
pubmed: 30472038
Cell. 2011 Jul 22;146(2):318-31
pubmed: 21757228
Nat Biotechnol. 2018 Oct;36(9):865-874
pubmed: 30125269
Mucosal Immunol. 2015 Jan;8(1):80-93
pubmed: 24917457
Front Cell Neurosci. 2018 Aug 06;12:242
pubmed: 30127723
Results Immunol. 2013 Aug 05;3:79-84
pubmed: 24600562
Cell Stem Cell. 2018 Mar 1;22(3):310-324
pubmed: 29499151
Lab Chip. 2016 Dec 20;17(1):156-168
pubmed: 27910972
Cell. 2016 Dec 1;167(6):1469-1480.e12
pubmed: 27912057
Nature. 2020 Jun;582(7810):89-94
pubmed: 32483373
Dev Cell. 2018 Jun 4;45(5):606-620.e3
pubmed: 29731343
J Neurol Sci. 1983 Aug-Sep;60(3):443-51
pubmed: 6355398
PLoS Comput Biol. 2020 Apr 29;16(4):e1007847
pubmed: 32348298
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Mol Cell. 2019 Mar 7;73(5):1001-1014.e8
pubmed: 30527540
Cell. 2017 Oct 5;171(2):273-285
pubmed: 28985560
Drug Metab Dispos. 2015 Jul;43(7):1091-9
pubmed: 25926431
Annu Rev Pathol. 2018 Jan 24;13:379-394
pubmed: 29195051
Ann Neurol. 1996 Nov;40(5):767-75
pubmed: 8957018
Sci Rep. 2017 Dec;7(1):174
pubmed: 28282965
Nat Med. 2016 Nov;22(11):1358-1367
pubmed: 27668937
Clin Cancer Res. 1995 Jan;1(1):129-36
pubmed: 9815895
Front Mol Neurosci. 2018 Apr 27;11:144
pubmed: 29755317
Nature. 1990 Feb 1;343(6257):425-30
pubmed: 1967820
PLoS One. 2015 Dec 04;10(12):e0142976
pubmed: 26636339
Nat Neurosci. 2018 Oct;21(10):1332-1340
pubmed: 30250260
Cell. 2016 Jun 2;165(6):1332-1345
pubmed: 27259147
Prog Neurobiol. 2008 Feb;84(2):105-15
pubmed: 18191887
Biomed Pharmacother. 2017 Jun;90:724-730
pubmed: 28419968
Biomaterials. 2020 Sep;254:120125
pubmed: 32502894
Cell Death Differ. 2006 Jan;13(1):96-108
pubmed: 15976810
Cell Mol Gastroenterol Hepatol. 2018 Apr 12;6(2):133-148
pubmed: 30023410
AAPS J. 2017 Sep;19(5):1499-1512
pubmed: 28752430
Neurobiol Dis. 2018 Dec;120:1-11
pubmed: 30149180
Nat Commun. 2018 Feb 06;9:16176
pubmed: 29405195
Nature. 2013 Dec 19;504(7480):446-50
pubmed: 24226770
Neurology. 2004 Nov 23;63(10):1912-7
pubmed: 15557511
Sci Transl Med. 2019 Jun 19;11(497):
pubmed: 31217335
Cell. 2009 Oct 30;139(3):485-98
pubmed: 19836068
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970