Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story.
COVID-19
Chloroquine
Hydroxychloroquine
Metabolism
SARS-CoV-2
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
07
06
2020
accepted:
03
01
2021
revised:
23
12
2020
pubmed:
31
1
2021
medline:
23
2
2021
entrez:
30
1
2021
Statut:
ppublish
Résumé
The anti-malarial drugs chloroquine (CQ) and hydroxychloroquine (HCQ) have been suggested as promising agents against the new coronavirus SARS-CoV-2 that induces COVID-19 and as a possible therapy for shortening the duration of the viral disease. The antiviral effects of CQ and HCQ have been demonstrated in vitro due to their ability to block viruses like coronavirus SARS in cell culture. CQ and HCQ have been proposed to reduce immune reactions to infectious agents, inhibit pneumonia exacerbation, and improve lung imaging investigations. CQ analogs have also revealed the anti-inflammatory and immunomodulatory effects in treating viral infections and related ailments. There was, moreover, convincing evidence from early trials in China about the efficacy of CQ and HCQ in the anti-COVID-19 procedure. Since then, research and studies have been massive to ascertain these drugs' efficacy and safety in treating the viral disease. In the present review, we construct a synopsis of the main properties and current data concerning the metabolism of CQ/HCQ, which were the basis of assessing their potential therapeutic roles against the new coronavirus infection. The effective role of QC and HCQ in the prophylaxis and therapy of COVID-19 infection is discussed in light of the latest international medical-scientific research results. KEY POINTS: • Data concerning metabolism and properties of CQ/HCQ are discussed. • The efficacy of CQ/HCQ against COVID-19 has been the subject of contradictory results. • CQ/HCQ has little or no effect in reducing mortality in SARS-CoV-2-affected patients.
Identifiants
pubmed: 33515285
doi: 10.1007/s00253-021-11094-4
pii: 10.1007/s00253-021-11094-4
pmc: PMC7847229
doi:
Substances chimiques
Antimalarials
0
Antiviral Agents
0
Hydroxychloroquine
4QWG6N8QKH
Chloroquine
886U3H6UFF
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1333-1343Références
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