The Quest for the Hippocampal Memory Engram: From Theories to Experimental Evidence.
engram
hippocampus
learning
memory
place
Journal
Frontiers in behavioral neuroscience
ISSN: 1662-5153
Titre abrégé: Front Behav Neurosci
Pays: Switzerland
ID NLM: 101477952
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
11
2020
accepted:
17
12
2020
entrez:
1
2
2021
pubmed:
2
2
2021
medline:
2
2
2021
Statut:
epublish
Résumé
More than a century after Richard Semon's theoretical proposal of the memory engram, technological advancements have finally enabled experimental access to engram cells and their functional contents. In this review, we summarize theories and their experimental support regarding hippocampal memory engram formation and function. Specifically, we discuss recent advances in the engram field which help to reconcile two main theories for how the hippocampus supports memory formation: The Memory Indexing and Cognitive Map theories. We also highlight the latest evidence for engram allocation mechanisms through which memories can be linked or separately encoded. Finally, we identify unanswered questions for future investigations, through which a more comprehensive understanding of memory formation and retrieval may be achieved.
Identifiants
pubmed: 33519396
doi: 10.3389/fnbeh.2020.632019
pmc: PMC7843437
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
632019Subventions
Organisme : NICHD NIH HHS
ID : P50 HD104458
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD084215
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH086403
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS077906
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS115660
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH019908
Pays : United States
Informations de copyright
Copyright © 2021 Miry, Li and Chen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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