The Scientific Foundation of Chinese Herbal Medicine against COVID-19.
Antiviral
Chinese herbal medicine
Coronavirus disease 2019
Cytokine storm
Lung fibrosis
Severe acute respiratory syndrome coronavirus
Journal
Engineering (Beijing, China)
ISSN: 2095-8099
Titre abrégé: Engineering (Beijing)
Pays: China
ID NLM: 101673395
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
13
04
2020
revised:
15
07
2020
accepted:
10
08
2020
entrez:
1
2
2021
pubmed:
2
2
2021
medline:
2
2
2021
Statut:
ppublish
Résumé
The recent coronavirus disease 2019 (COVID-19) pandemic outbreak has caused a serious global health emergency. Supporting evidence shows that COVID-19 shares a genomic similarity with other coronaviruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), and that the pathogenesis and treatment strategies that were applied 17 years ago in combating SARS-CoV and other viral infections could be taken as references in today's antiviral battle. According to the clinical pathological features of COVID-19 patients, patients can suffer from five steps of progression, starting with severe viral infection and suppression of the immune system and eventually progressing to cytokine storm, multi-organ damage, and lung fibrosis, which is the cause of mortality. Therefore, early prevention of disease progression is important. However, no specific effective drugs and vaccination are currently available, and the World Health Organization is urging the development of novel prevention and treatment strategies. Traditional Chinese medicine could be used as an alternative treatment option or in combination with Western medicine to treat COVID-19, due to its basis on historical experience and holistic pharmacological action. Here, we summarize the potential uses and therapeutic mechanisms of Chinese herbal formulas (CHFs) from the reported literature, along with patent drugs that have been recommended by institutions at the national and provincial levels in China, in order to verify their scientific foundations for treating COVID-19. In perspective, more basic and clinical studies with multiple high-tech and translational technologies are suggested to further confirm the therapeutic efficacies of CHFs.
Identifiants
pubmed: 33520331
doi: 10.1016/j.eng.2020.08.009
pii: S2095-8099(20)30236-8
pmc: PMC7833648
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1099-1107Informations de copyright
© 2020 THE AUTHORS.
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