Intrinsic spectrally-dependent background in spectroscopic visible-light optical coherence tomography.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Jan 2021
01 Jan 2021
Historique:
received:
11
09
2020
revised:
15
11
2020
accepted:
16
11
2020
entrez:
1
2
2021
pubmed:
2
2
2021
medline:
2
2
2021
Statut:
epublish
Résumé
Visible-light optical coherence tomography (vis-OCT) has enabled new spectroscopic applications, such as retinal oximetry, as a result of increased optical absorption and scattering contacts in biological tissue and improved axial resolution. Besides extracting tissue properties from back-scattered light, spectroscopic analyses must consider spectral alterations induced by image reconstruction itself. We investigated an intrinsic spectral bias in the background noise floor, which is hereby referred to as the spectrally-dependent background (SDBG). We developed an analytical model to predict the SDBG-induced bias and validated this model using numerically simulated and experimentally acquired data. We found that SDBG systemically altered the measured spectra of blood in human retinal vessels in vis-OCT, as compared to literature data. We provided solutions to quantify and compensate for SDBG in retinal oximetry. This work is particularly significant for clinical applications of vis-OCT.
Identifiants
pubmed: 33520380
doi: 10.1364/BOE.410011
pii: 410011
pmc: PMC7818955
doi:
Types de publication
Journal Article
Langues
eng
Pagination
110-124Subventions
Organisme : NEI NIH HHS
ID : R44 EY026466
Pays : United States
Organisme : NEI NIH HHS
ID : T32 EY025202
Pays : United States
Informations de copyright
© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
Déclaration de conflit d'intérêts
RVK and HFZ have financial interests in Opticent Health.
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