Malignant Epithelioid Soft Tissue Tumours- A Pathologist's Perspective With Review of Literature.
immunohistochemistry
pathologists
sarcoma
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
24 Dec 2020
24 Dec 2020
Historique:
entrez:
1
2
2021
pubmed:
2
2
2021
medline:
2
2
2021
Statut:
epublish
Résumé
Background Soft tissue tumours with epithelioid morphology have many differential diagnoses, which include epithelioid sarcoma, malignant extrarenal rhabdoid tumour, epithelioid malignant peripheral nerve sheath tumour, epithelioid leiomyosarcoma, epithelioid angiosarcoma and sclerosing epithelioid fibrosarcoma. There are other rare entities also. They often express characteristic patterns of immunohistochemical markers that can be used to identify these tumours. Materials and methods This retrospective study comprises 22 cases of malignant soft tissue tumours with epithelioid differentiation diagnosed over a period of four years. Findings regarding clinical presentation, cytological findings, histopathological findings and immunohistochemical profile of the tumours were noted and analyzed. Results A total of 22 cases were included in the study including five cases of epithelioid sarcoma (conventional and proximal), three cases of epithelioid angiosarcoma and epithelioid myxofibrosarcoma, two cases of epithelioid malignant peripheral nerve sheath tumour, epithelioid gastrointestinal stromal tumour and clear cell sarcoma each, one case of epithelioid leiomyosarcoma, sclerosing epithelioid fibrosarcoma, malignant extrarenal rhabdoid tumour, monophasic synovial sarcoma and malignant and malignant perivascular epithelioid cell tumour each. Conclusion Pathologists should be aware of the various differential diagnoses of soft tissue tumours with epithelioid morphology. Over and above the clinical findings and morphological features, ancillary methods like immunohistochemistry help to arrive at a definitive diagnosis in most cases.
Identifiants
pubmed: 33520482
doi: 10.7759/cureus.12263
pmc: PMC7834554
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12263Informations de copyright
Copyright © 2020, Dey et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Arch Pathol Lab Med. 2011 Feb;135(2):268-72
pubmed: 21284449
Ann Diagn Pathol. 1998 Dec;2(6):351-62
pubmed: 9930572
Rare Tumors. 2013 May 31;5(2):60-1
pubmed: 23888215
Am J Surg Pathol. 2005 Dec;29(12):1558-75
pubmed: 16327428
Surg Pathol Clin. 2015 Sep;8(3):309-29
pubmed: 26297059
Arch Pathol Lab Med. 1989 Jan;113(1):55-60
pubmed: 2521288
Am J Clin Pathol. 2009 Feb;131(2):222-7
pubmed: 19141382
Cancer. 2003 Dec 15;98(12):2700-7
pubmed: 14669292
Am J Surg Pathol. 1997 Feb;21(2):130-46
pubmed: 9042279
World J Surg Oncol. 2010 Nov 21;8:102
pubmed: 21092139
Arch Pathol Lab Med. 2011 Oct;135(10):1298-310
pubmed: 21970485
Semin Oncol. 2009 Aug;36(4):347-57
pubmed: 19664495
Cancer. 1970 Nov;26(5):1029-41
pubmed: 5476785
Am J Surg Pathol. 1991 Oct;15(10):915-24
pubmed: 1718176
Virchows Arch. 2008 Feb;452(2):119-32
pubmed: 18080139
Mod Pathol. 2014 Jan;27 Suppl 1:S64-79
pubmed: 24384854
Am J Surg Pathol. 2015 May;39(5):673-82
pubmed: 25602794
Cytopathology. 2016 Dec;27(6):499-501
pubmed: 27018045
Am J Surg Pathol. 1995 Sep;19(9):979-93
pubmed: 7661286
Am J Surg Pathol. 2007 Jan;31(1):99-105
pubmed: 17197925
Arch Pathol Lab Med. 2002 Apr;126(4):468-70
pubmed: 11900575
Diagn Pathol. 2013 Apr 15;8:60
pubmed: 23587410