Granuloma Annulare - A Manifestation of Primary Cutaneous Mucinous Carcinoma?
granuloma annulare
paraneoplastic
paraneoplastic granuloma annulare
primary cutaneous mucinous carcinoma
primary mucinous carcinoma of skin
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
26 Dec 2020
26 Dec 2020
Historique:
entrez:
1
2
2021
pubmed:
2
2
2021
medline:
2
2
2021
Statut:
epublish
Résumé
The objective of this report is to present a rare case of primary cutaneous mucinous carcinoma (PCMC) manifesting with granuloma annulare (GA), and to discuss the association as a paraneoplastic phenomenon. A 65-year-old female presented with a painless, slow-growing, cystic nodule less than 1 cm over the left lateral canthus. The clinical presentation was highly suspicious of sebaceous cyst. The histopathologic examination revealed variable sizes of neoplastic cell clusters in a pool of abundant mucin. A focus of palisading lympho-histiocytic infiltrate surrounding a necrobiosis suggestive of granuloma annulare adjacent to the tumor is identified. Series of extensive investigations performed did not reveal any primary origin. GA can rarely be associated with various malignant conditions. Its association and prognostic importance to these conditions are unclear. The presence with certain malignancies and the resolution of GA with the treatment of underlying malignancy are an indicator that this condition can very well be a paraneoplastic phenomenon.
Identifiants
pubmed: 33520503
doi: 10.7759/cureus.12304
pmc: PMC7834588
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e12304Informations de copyright
Copyright © 2020, Bagci et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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