Stress Granules in the Post-transcriptional Regulation of Immune Cells.
RNA-binding proteins (RBP)
immune cells
integrated stress response (ISR)
mRNA
mTOR
post-transcriptional regulation
stress granules (SG)
translation
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
09
2020
accepted:
07
12
2020
entrez:
1
2
2021
pubmed:
2
2
2021
medline:
2
2
2021
Statut:
epublish
Résumé
Immune cell activation triggers transcriptional and translational programs eliciting cellular processes, such as differentiation or proliferation, essential for an efficient immune response. These dynamic processes require an intricate orchestration of regulatory mechanisms to control the precise spatiotemporal expression of proteins. Post-transcriptional regulation ensures the control of messenger RNA metabolism and appropriate translation. Among these post-transcriptional regulatory mechanisms, stress granules participate in the control of protein synthesis. Stress granules are ribonucleoprotein complexes that form upon stress, typically under control of the integrated stress response. Such structures assemble upon stimulation of immune cells where they control selective translational programs ensuring the establishment of accurate effector functions. In this review, we summarize the current knowledge about post-transcriptional regulation in immune cells and highlight the role of stress sensors and stress granules in such regulation.
Identifiants
pubmed: 33520991
doi: 10.3389/fcell.2020.611185
pmc: PMC7841200
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
611185Informations de copyright
Copyright © 2021 Curdy, Lanvin, Cadot, Laurent, Fournié and Franchini.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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