Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis.
dimethylarginine dimethylaminohydrolase
macromolecular damage
nitric oxide
pulmonary fibrosis
radiation
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
08
2020
accepted:
17
12
2020
entrez:
1
2
2021
pubmed:
2
2
2021
medline:
2
2
2021
Statut:
epublish
Résumé
Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options.
Identifiants
pubmed: 33521012
doi: 10.3389/fmed.2020.585756
pmc: PMC7843914
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
585756Informations de copyright
Copyright © 2021 Jarzebska, Karetnikova, Markov, Kasper, Rodionov and Spieth.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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