Transcriptional Riboswitches Integrate Timescales for Bacterial Gene Expression Control.
RNA folding
RNA polymerase
riboswitch control of gene expression
structural dynamics
transcription
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
09
2020
accepted:
11
12
2020
entrez:
1
2
2021
pubmed:
2
2
2021
medline:
2
2
2021
Statut:
epublish
Résumé
Transcriptional riboswitches involve RNA aptamers that are typically found in the 5' untranslated regions (UTRs) of bacterial mRNAs and form alternative secondary structures upon binding to cognate ligands. Alteration of the riboswitch's secondary structure results in perturbations of an adjacent expression platform that controls transcription elongation and termination, thus turning downstream gene expression "on" or "off." Riboswitch ligands are typically small metabolites, divalent cations, anions, signaling molecules, or other RNAs, and can be part of larger signaling cascades. The interconnectedness of ligand binding, RNA folding, RNA transcription, and gene expression empowers riboswitches to integrate cellular processes and environmental conditions across multiple timescales. For a successful response to an environmental cue that may determine a bacterium's chance of survival, a coordinated coupling of timescales from microseconds to minutes must be achieved. This review focuses on recent advances in our understanding of how riboswitches affect such critical gene expression control across time.
Identifiants
pubmed: 33521053
doi: 10.3389/fmolb.2020.607158
pmc: PMC7838592
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
607158Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM122803
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM118524
Pays : United States
Organisme : NIGMS NIH HHS
ID : F32 GM140547
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007544
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM062357
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131922
Pays : United States
Informations de copyright
Copyright © 2021 Scull, Dandpat, Romero and Walter.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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