An audit of disseminated intravascular coagulation screen requests at an academic hospital laboratory in central South Africa.
ISTH score
disseminated intravascular coagulation
fibrinogen
platelet count
pretest diagnosis
Journal
International journal of laboratory hematology
ISSN: 1751-553X
Titre abrégé: Int J Lab Hematol
Pays: England
ID NLM: 101300213
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
revised:
17
12
2020
received:
06
08
2020
accepted:
21
12
2020
pubmed:
2
2
2021
medline:
30
11
2021
entrez:
1
2
2021
Statut:
ppublish
Résumé
Disseminated intravascular coagulation (DIC) is a feared complication of various systemic illnesses. We aimed to evaluate the laboratory requesting practices of clinicians, especially concerning the laboratory parameters, included in the International Society of Thrombosis and Haemostasis (ISTH) DIC score. A retrospective descriptive study was performed and included data from DIC screen requests analysed at Universitas National Health Laboratory Service (NHLS) laboratory, Bloemfontein, South Africa, for one calendar year. Laboratory request forms were analysed, recording the pretest diagnosis and whether the diagnosis was associated with DIC. Parameters of the DIC screen, prothrombin time, activated partial thromboplastin time, thrombin time, d-dimer and fibrinogen were used to calculate the ITSH DIC score and diagnose heparin contamination. The platelet count, currently not part of the DIC screen test set, was also recorded. A total of 778 DIC screen requests were processed. One hundred and eighty-three requests were excluded due to laboratory-defined rejection criteria, heparin contamination or for lacking an ISTH score parameter. Of the remaining 595 complete requests, 283 (47.7%) were laboratory-defined overt DIC. The pretest diagnosis was not predictive of either a positive or negative finding of overt DIC. The contribution of fibrinogen to assigning overt DIC was questionable. The number of DIC screen requests received highlights the need for laboratory evidence of DIC. To improve laboratory DIC testing, the authors suggest critical evaluation of the contribution of the pretest diagnosis and fibrinogen in a prospective study and adding the platelet count in our local DIC test set.
Substances chimiques
Fibrin Fibrinogen Degradation Products
0
fibrin fragment D
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1174-1180Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
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