Genetic and environmental components of vertical growth in mono- and dizygotic twins up to 15-18 years of age.
Cephalometrics
Cohort study
Craniofacial growth
Genetics
Mandibular growth
Twins
Journal
The Angle orthodontist
ISSN: 1945-7103
Titre abrégé: Angle Orthod
Pays: United States
ID NLM: 0370550
Informations de publication
Date de publication:
01 05 2021
01 05 2021
Historique:
accepted:
01
12
2020
received:
01
06
2020
pubmed:
2
2
2021
medline:
11
5
2021
entrez:
1
2
2021
Statut:
ppublish
Résumé
To determine the additive genetic and environmental contributions to the vertical growth of craniofacial structures. The sample consisted of 64 untreated monozygotic (44 male, 20 female) and 61 untreated dizygotic twins (32 male, 29 female). Lateral cephalograms taken at 15 and 18 years of age were traced to analyze the sella-nasion-nasal line angle (SN-NL), nasal line-mandibular line angle (ML-NL), sella-nasion-mandibular line angle (SN-ML), sella-nasion-sella-gnathion angle (Y-axis), posterior face height/anterior face height (PFH/AFH), and lower anterior face height/anterior face height (LAFH/AFH). The genetic and environmental components of variance were analyzed with structural equation modeling for multilevel mixed effects. At 15 years of age, strong dominant genetic control was seen for NL-ML (81%), LAFH/AFH (73%), and Y-axis (57%), whereas strong additive genetic components were found for PFH/AFH (78%), SN-NL (58%), and SN-ML (57%). Unique environmental factors accounted for 18-42% of observed variance, with SN-NL being affected the most (42%). At 18 years of age, only LAFH/AFH (86%) was under strong dominant genetic control, whereas the remainder were under additive genetic influence. The sole exception was SN-NL, which changed from additive to unique environmental influence. Either additive or dominant genetic components were found at 15 or 18 years of age for most vertical variables. Environmental factors accounted for about 10-40%, with SN-NL being mostly affected.
Identifiants
pubmed: 33523142
pii: 451996
doi: 10.2319/060520-515.1
pmc: PMC8084456
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
384-390Informations de copyright
© 2021 by The EH Angle Education and Research Foundation, Inc.
Références
Am J Orthod Dentofacial Orthop. 1993 Jan;103(1):33-8
pubmed: 8422028
Am J Orthod. 1966 Aug;52(8):576-83
pubmed: 5220744
Aust Dent J. 1990 Aug;35(4):317-27
pubmed: 2099767
Eur J Orthod. 1986 Nov;8(4):259-64
pubmed: 3466800
Med Sci Monit. 2014 Oct 24;20:2036-42
pubmed: 25344319
Rep Congr Eur Orthod Soc. 1965;41:59-70
pubmed: 5222375
Clin Orthod Res. 2001 Aug;4(3):130-40
pubmed: 11553097
Angle Orthod. 1998 Oct;68(5):467-70
pubmed: 9770105
Psychol Bull. 2000 May;126(3):390-423
pubmed: 10825783
J Craniofac Surg. 2018 May;29(3):e274-e279
pubmed: 29419588
Eur J Orthod. 1987 May;9(2):104-8
pubmed: 3472887
Acta Genet Med Gemellol (Roma). 1996;45(3):349-60
pubmed: 9014000
Twin Res Hum Genet. 2006 Apr;9(2):194-7
pubmed: 16611487
Am J Orthod Dentofacial Orthop. 1991 Mar;99(3):258-68
pubmed: 1998301
Am J Orthod. 1973 Dec;64(6):578-606
pubmed: 4210182
Eur J Orthod. 2016 Oct;38(5):493-502
pubmed: 26503948
Lancet. 1986 Feb 8;1(8476):307-10
pubmed: 2868172
Twin Res Hum Genet. 2015 Jun;18(3):306-13
pubmed: 25869010
Am J Orthod. 1982 Aug;82(2):150-6
pubmed: 6961785
Eur J Orthod. 2005 Dec;27(6):556-61
pubmed: 16257991
Angle Orthod. 2000 Dec;70(6):471-83
pubmed: 11138651
Minerva Stomatol. 2018 Jun;67(3):77-85
pubmed: 29308854
Angle Orthod. 1973 Jul;43(3):314-22
pubmed: 4515778
Med Sci Monit. 2015 Jun 18;21:1765-73
pubmed: 26086193
Am J Orthod Dentofacial Orthop. 1993 Nov;104(5):471-83
pubmed: 8237899
Eur J Orthod. 1984 May;6(2):77-91
pubmed: 6587973
Am J Hum Genet. 1974 Mar;26(2):154-61
pubmed: 4856692
Arch Oral Biol. 2009 Dec;54 Suppl 1:S45-51
pubmed: 18715551
Acta Genet Med Gemellol (Roma). 1955 May;4(2):143-60
pubmed: 14387520
Orthod Craniofac Res. 2020 May;23(2):192-201
pubmed: 31746097
Am J Orthod Dentofacial Orthop. 2018 Nov;154(5):683-692
pubmed: 30384939
J Anim Sci. 1997 Nov;75(11):2885-91
pubmed: 9374300
Am J Orthod. 1969 Jun;55(6):566-77
pubmed: 5253955
Am J Orthod Dentofacial Orthop. 1997 Jan;111(1):44-51
pubmed: 9009923