Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease.
Alpha-melanocyte-stimulating hormone
Cardiopulmonary exercise test
Coronary artery disease
Journal
Hormones (Athens, Greece)
ISSN: 2520-8721
Titre abrégé: Hormones (Athens)
Pays: Switzerland
ID NLM: 101142469
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
15
07
2020
accepted:
22
12
2020
pubmed:
2
2
2021
medline:
18
12
2021
entrez:
1
2
2021
Statut:
ppublish
Résumé
Alpha-melanocyte-stimulating hormone (alpha-MSH) has proven cardiovascular effects and plays a significant role as an endogenous countermeasure to ischemia-reperfusion injury. The aim of the current study was to examine the response of alpha-MSH during exercise in patients diagnosed with coronary artery disease (CAD) and evaluate its value in the assessment of severity and prognosis. Forty subjects with documented CAD (i.e., lesions on coronary angiography ≥ 50%) were included. Cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits, 2-4 days apart, during 2 months of coronary angiography; subsequently, the subjects were followed up for 32 ± 10 months. At rest, at peak CPET, and after 3 min of recovery, plasma levels of alpha-MSH were measured by enzyme-linked immunosorbent assay technique. Mean ejection fraction was 56.7 ± 9.6%. Alpha-MSH similarly increased from rest to peak CPET on both modalities. There were no significant differences in alpha-MSH values during testing in patients with 1,2- and 3-vesel CAD, nor in patients with a SYNTAX score </≥ 23 (p > 0.05). Among CPET and hormonal parameters, ∆alpha-MSH recovery/peak during RE CPET was the best predictor of cardiac event occurrence (chi-square 6.67, HR = 0.51, CI = 0.25-1.02, p = 0.010). ∆alpha-MSH recovery/peak during RE CPET has predictive value for CAD prognosis, demonstrating involvement of alpha-MSH in CAD and a link between stress hormones and cardiac events.
Identifiants
pubmed: 33523420
doi: 10.1007/s42000-020-00270-2
pii: 10.1007/s42000-020-00270-2
doi:
Substances chimiques
alpha-MSH
581-05-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
381-387Références
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