Animals Bone Morphogenetic Protein 1 / metabolism Half-Life Humans Metalloproteases / metabolism Mice Proof of Concept Study Protease Inhibitors / pharmacokinetics Serum Albumin, Human / metabolism Small Molecule Libraries / metabolism

Journal

Bioconjugate chemistry
ISSN: 1520-4812
Titre abrégé: Bioconjug Chem
Pays: United States
ID NLM: 9010319

Informations de publication

Date de publication:
17 02 2021
Historique:
pubmed: 2 2 2021
medline: 18 8 2021
entrez: 1 2 2021
Statut: ppublish

Résumé

Reducing the required frequence of drug dosing can improve the adherence of patients to chronic treatments. Hence, drugs with longer

Identifiants

DOI: 10.1021/acs.bioconjchem.0c00662 PMID: 33523652
pubmed: 33523652
doi: 10.1021/acs.bioconjchem.0c00662
doi:

Substances chimiques

Protease Inhibitors 0
Small Molecule Libraries 0
Metalloproteases EC 3.4.-
Bone Morphogenetic Protein 1 EC 3.4.24.19
Serum Albumin, Human ZIF514RVZR

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

279-289

Auteurs

Julien C Vantourout (JC)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G11XL, U.K.

Andrew M Mason (AM)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Josephine Yuen (J)

GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.

Graham L Simpson (GL)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Ghotas Evindar (G)

GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.

Letian Kuai (L)

GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.

Michael Hobbs (M)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Emma Edgar (E)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Saul Needle (S)

GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

Xiaopeng Bai (X)

GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.

Steve Wilson (S)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Paul Scott-Stevens (P)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

William Traylen (W)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Kim Lambert (K)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Neil Young (N)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Shenaz Bunally (S)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Scott G Summerfield (SG)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Richard Snell (R)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Rakesh Lad (R)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Eric Shi (E)

GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.

Steven Skinner (S)

GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.

Lisa Shewchuk (L)

GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

Allan J B Watson (AJB)

University of St Andrews, North Haugh, St Andrews KY16 9ST, U.K.
ORCID: 0000-0002-1582-4286

Chun-Wa Chung (CW)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
ORCID: 0000-0002-2480-3110

Sandeep Pal (S)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Dennis A Holt (DA)

GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

Lara S Kallander (LS)

GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

Joanne Prendergast (J)

GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

Katrina Rivera (K)

GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

David G Washburn (DG)

GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

Mark R Harpel (MR)

GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

Christopher Arico-Muendel (C)

GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.

Albert Isidro-Llobet (A)

GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
ORCID: 0000-0001-9108-5916

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux ›
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Tolloid-Like Metalloproteinases › Protéine morphogénétique osseuse de type 1 ›
questionsmedicales.fr › Phénomènes physiques › Temps › Période ›
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains ›
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Metalloproteases ›
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris ›
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Étude de validation de principe ›
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases ›
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Sérumalbumine › Sérum-albumine humaine ›
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Bibliothèques de petites molécules ›