Study on the association of wall shear stress and vessel structural stress with atherosclerosis: An experimental animal study.

Animals Atherosclerosis Carotid Arteries / diagnostic imaging Constriction, Pathologic Hemodynamics Models, Cardiovascular Plaque, Atherosclerotic Rabbits Shear Strength Stress, Mechanical

Artery Atherosclerosis Vessel structural stress Wall shear stress

Journal

Atherosclerosis

ISSN: 1879-1484

Titre abrégé: Atherosclerosis

Pays: Ireland

ID NLM: 0242543

Informations de publication

Date de publication:
03 2021

Historique:

received: 14 05 2020

revised: 07 01 2021

accepted: 13 01 2021

pubmed: 2 2 2021

medline: 24 6 2021

entrez: 1 2 2021

Statut: ppublish

Résumé

Artery is subject to wall shear stress (WSS) and vessel structural stress (VSS) simultaneously. This study is designed to explore the role of VSS in development of atherosclerosis. Silastic collars were deployed on the carotid to create two constrictions on 13 rabbits for a distinct mechanical environment at the constriction. MRI was performed to visualize arteries' configuration. Animals with high fat (n = 9; Model-group) and normal diet (n = 4; Control-group) were sacrificed after 16 weeks. 3D fluid-structure interaction analysis was performed to quantify WSS and VSS simultaneously. Twenty plaques were found in Model-group and 3 in Control-group. In Model-group, 8 plaques located proximally to the first constriction (Region-1, close to the heart) and 7 distally to the second (Region-2, close to the head) and 5 plaques were found on the contralateral side of 3 rabbits. Plaques at Region-1 tended to be bigger than those at Region-2 and the macrophage density at these locations was comparable. Minimum time-averaged WSS (TAWSS) in Region-1 was significantly higher than that in Region-2, and both maximum oscillatory shear index (OSI) and particle relative residence time (RRT) were significantly lower. Peak and mean VSS in Region-1 were significantly higher than those in Region-2. Correlation analyses indicated that low TAWSS, high OSI and RRT were only associated with plaque in Region-2, while lesions in Region-1 were only associated with high VSS. Moreover, only VSS was associated with wall thickness of plaque-free regions in both regions. VSS might contribute to the initialization and development of atherosclerosis solely or in combination with WSS.

Sections du résumé

BACKGROUND AND AIMS

Artery is subject to wall shear stress (WSS) and vessel structural stress (VSS) simultaneously. This study is designed to explore the role of VSS in development of atherosclerosis.

METHODS

Silastic collars were deployed on the carotid to create two constrictions on 13 rabbits for a distinct mechanical environment at the constriction. MRI was performed to visualize arteries' configuration. Animals with high fat (n = 9; Model-group) and normal diet (n = 4; Control-group) were sacrificed after 16 weeks. 3D fluid-structure interaction analysis was performed to quantify WSS and VSS simultaneously.

RESULTS

Twenty plaques were found in Model-group and 3 in Control-group. In Model-group, 8 plaques located proximally to the first constriction (Region-1, close to the heart) and 7 distally to the second (Region-2, close to the head) and 5 plaques were found on the contralateral side of 3 rabbits. Plaques at Region-1 tended to be bigger than those at Region-2 and the macrophage density at these locations was comparable. Minimum time-averaged WSS (TAWSS) in Region-1 was significantly higher than that in Region-2, and both maximum oscillatory shear index (OSI) and particle relative residence time (RRT) were significantly lower. Peak and mean VSS in Region-1 were significantly higher than those in Region-2. Correlation analyses indicated that low TAWSS, high OSI and RRT were only associated with plaque in Region-2, while lesions in Region-1 were only associated with high VSS. Moreover, only VSS was associated with wall thickness of plaque-free regions in both regions.

CONCLUSIONS

VSS might contribute to the initialization and development of atherosclerosis solely or in combination with WSS.

Identifiants

DOI: 10.1016/j.atherosclerosis.2021.01.017 PMID: 33524908

pubmed: 33524908

pii: S0021-9150(21)00030-7

doi: 10.1016/j.atherosclerosis.2021.01.017

pii:

doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng