Hepatitis B Core-Related Antigen as Surrogate Biomarker of Intrahepatic Hepatitis B Virus Covalently-Closed-Circular DNA in Patients with Chronic Hepatitis B: A Meta-Analysis.
HBV cccDNA
HBcrAg
HBeAg
HBsAg
chronic HBV infection
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
28 Jan 2021
28 Jan 2021
Historique:
received:
10
12
2020
revised:
25
01
2021
accepted:
26
01
2021
entrez:
2
2
2021
pubmed:
3
2
2021
medline:
3
2
2021
Statut:
epublish
Résumé
Hepatitis B virus (HBV) covalently-closed-circular (ccc)DNA is the key molecule responsible for viral persistence within infected hepatocytes. The evaluation of HBV cccDNA is crucial for the management of patients with chronic HBV infection and for the personalization of treatment. However, the need for liver biopsy is the principal obstacle for the assessment of intrahepatic HBV cccDNA. In the last decade, several studies have investigated the performance of hepatitis B core-related antigen (HBcrAg) as a surrogate of HBV cccDNA amount in the liver. In this meta-analysis, we collected 14 studies (1271 patients) investigating the correlation between serum HBcrAg and intrahepatic HBV cccDNA. Serum HBcrAg showed a high correlation with intrahepatic HBV cccDNA (
Identifiants
pubmed: 33525443
pii: diagnostics11020187
doi: 10.3390/diagnostics11020187
pmc: PMC7910971
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Progetti di ricerca di Rilevante Interesse Nazionale (PRIN) - 2015
ID : 201572SHXJ
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